| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.109667 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0779096 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0760164 |
| TXNRD1 | thioredoxin reductase 1 | 0.063622 |
| KRT18 | keratin 18, type I | 0.0570878 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0516549 |
| RAD51B | RAD51 paralog B | 0.0516324 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0493534 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.040565 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0398789 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0371959 |
| COPA | coatomer protein complex, subunit alpha | 0.0363546 |
| BBX | bobby sox homolog (Drosophila) | 0.0342403 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0335782 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0330134 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0326828 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0316849 |
| ADAR | adenosine deaminase, RNA-specific | 0.0309401 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0307222 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0305526 |
| XPO1 | exportin 1 | 0.02929 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0288963 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0287417 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.027605 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0273489 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0269091 |
| PHIP | pleckstrin homology domain interacting protein | 0.0264652 |
| GOLGA4 | golgin A4 | 0.0263074 |
| MED13L | mediator complex subunit 13-like | 0.0262494 |
| ZNF292 | zinc finger protein 292 | 0.0261088 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0258117 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0257242 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0255736 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0252183 |
| MKI67 | marker of proliferation Ki-67 | 0.0248307 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0246861 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0241734 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0240273 |
| ATXN2 | ataxin 2 | 0.0239153 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0238233 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0237783 |
| COG5 | component of oligomeric golgi complex 5 | 0.0234573 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0232557 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0229494 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0228957 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0227901 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0226847 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0224283 |
| HELZ | helicase with zinc finger | 0.0223642 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0222385 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0222299 |
| TPX2 | TPX2, microtubule-associated | 0.0222246 |
| SBF2 | SET binding factor 2 | 0.0221733 |
| DIAPH3 | diaphanous-related formin 3 | 0.0220291 |
| TPM3 | tropomyosin 3 | 0.0219866 |
| RLIM | ring finger protein, LIM domain interacting | 0.021907 |
| CANX | calnexin | 0.0218626 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0217753 |
| CCNL1 | cyclin L1 | 0.0214549 |
| PLCB4 | phospholipase C, beta 4 | 0.0213375 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0212052 |
| PCNX1 | pecanex 1 | 0.0211545 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0211064 |
| OGA | O-GlcNAcase | 0.0210914 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0207148 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0205323 |
| CEP192 | centrosomal protein 192kDa | 0.0204146 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0200508 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0199254 |
| TFG | TRK-fused gene | 0.0196155 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0195263 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0193263 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0190424 |
| AHNAK | AHNAK nucleoprotein | 0.0189703 |
| ANO6 | anoctamin 6 | 0.0188709 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0188237 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0187812 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0187769 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0186876 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0185673 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0185011 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0184877 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 0.0184476 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0184417 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0184384 |
| ARF4 | ADP-ribosylation factor 4 | 0.018409 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0183669 |
| H1-0 | H1.0 linker histone | 0.0183406 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0182518 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0182342 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0182265 |
| CENPF | centromere protein F, 350/400kDa | 0.0181797 |
| RRM2 | ribonucleotide reductase M2 | 0.0181665 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0181493 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0181469 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0181414 |
| WASF2 | WAS protein family, member 2 | 0.0180112 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0178329 |
| CLTC | clathrin, heavy chain (Hc) | 0.0177951 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0175672 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.332417 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0902994 |
| TMSB10 | thymosin beta 10 | -0.0692951 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0679574 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0599697 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0598722 |
| OSMR | oncostatin M receptor | -0.0581087 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0501449 |
| ACTG1 | actin gamma 1 | -0.0445628 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0434773 |
| HLA-B | major histocompatibility complex, class I, B | -0.0430936 |
| PDE10A | phosphodiesterase 10A | -0.0425953 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0414822 |
| VIM | vimentin | -0.0411146 |
| AFF3 | AF4/FMR2 family, member 3 | -0.04105 |
| PTMA | prothymosin, alpha | -0.0396813 |
| IER3 | immediate early response 3 | -0.0384024 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.037756 |
| RPL35A | ribosomal protein L35a | -0.0370162 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0364284 |
| RPL37 | ribosomal protein L37 | -0.0355725 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0352939 |
| HMGA2 | high mobility group AT-hook 2 | -0.0340137 |
| RPS3 | ribosomal protein S3 | -0.0321496 |
| RPS8 | ribosomal protein S8 | -0.0319227 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0306839 |
| RPL37A | ribosomal protein L37a | -0.0301951 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.029941 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0294182 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0285373 |
| RPL26 | ribosomal protein L26 | -0.0283908 |
| RPS19 | ribosomal protein S19 | -0.0272592 |
| STC1 | stanniocalcin 1 | -0.0270336 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0269896 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0267321 |
| CAVIN1 | caveolae associated protein 1 | -0.0263475 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0260042 |
| RPL38 | ribosomal protein L38 | -0.0256061 |
| YBX3 | Y box binding protein 3 | -0.0255671 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.025518 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0254587 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0254577 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0253721 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0250135 |
| RYR3 | ryanodine receptor 3 | -0.0245901 |
| SVIL | supervillin | -0.0243236 |
| RPLP1 | ribosomal protein, large, P1 | -0.0239497 |
| MT2A | metallothionein 2A | -0.0235989 |
| ATP11A | ATPase, class VI, type 11A | -0.0231292 |
| RPL9 | ribosomal protein L9 | -0.0231283 |
| RPS27 | ribosomal protein S27 | -0.022259 |
| TPM4 | tropomyosin 4 | -0.0219132 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0216604 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0209079 |
| RPL34 | ribosomal protein L34 | -0.0205743 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0203868 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0202575 |
| RPL31 | ribosomal protein L31 | -0.0201021 |
| GRAMD1B | GRAM domain containing 1B | -0.0199697 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0197997 |
| RPS6 | ribosomal protein S6 | -0.0194628 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0194356 |
| WWOX | WW domain containing oxidoreductase | -0.0193097 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0191511 |
| RPS12 | ribosomal protein S12 | -0.0191333 |
| S100A10 | S100 calcium binding protein A10 | -0.0190038 |
| RPS21 | ribosomal protein S21 | -0.0189204 |
| S100A11 | S100 calcium binding protein A11 | -0.0188483 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0186197 |
| MCL1 | myeloid cell leukemia 1 | -0.018498 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0184063 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0181173 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0176596 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0174768 |
| RPS10 | ribosomal protein S10 | -0.0174636 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | -0.017436 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0171781 |
| DIAPH2 | diaphanous-related formin 2 | -0.0171543 |
| ATG7 | autophagy related 7 | -0.0170957 |
| RPL36 | ribosomal protein L36 | -0.0170546 |
| FMNL2 | formin-like 2 | -0.0167067 |
| TCIM | transcriptional and immune response regulator | -0.0166319 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.016622 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0160404 |
| LOXL2 | lysyl oxidase-like 2 | -0.0159367 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0158586 |
| BMERB1 | bMERB domain containing 1 | -0.0156785 |
| SUMF1 | sulfatase modifying factor 1 | -0.0156717 |
| RPS15 | ribosomal protein S15 | -0.0156714 |
| RPS24 | ribosomal protein S24 | -0.0155333 |
| CLDN1 | claudin 1 | -0.015507 |
| RPL36A | ribosomal protein L36a | -0.0154897 |
| GNAS | GNAS complex locus | -0.0151535 |
| RPL23 | ribosomal protein L23 | -0.0149267 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0148786 |
| COL5A2 | collagen, type V, alpha 2 | -0.0147585 |
| CDK17 | cyclin-dependent kinase 17 | -0.0147154 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0146212 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0146174 |
| RPL30 | ribosomal protein L30 | -0.0143949 |
