| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSC22D2 | TSC22 domain family, member 2 | 0.137229 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0938939 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0855627 |
| NDRG1 | N-myc downstream regulated 1 | 0.0823908 |
| POTEF | POTE ankyrin domain family, member F | 0.0821223 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0805555 |
| MYO6 | myosin VI | 0.077032 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0768058 |
| VEGFA | vascular endothelial growth factor A | 0.0765309 |
| PTMA | prothymosin, alpha | 0.0760435 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0753914 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0742729 |
| RNF145 | ring finger protein 145 | 0.0728745 |
| FTL | ferritin, light polypeptide | 0.0703672 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0694618 |
| COPA | coatomer protein complex, subunit alpha | 0.0669739 |
| FAM13A | family with sequence similarity 13, member A | 0.0647184 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0632184 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0610756 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0598731 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0597822 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0575012 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0564863 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0561026 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0560292 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0553091 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0501075 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0500288 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0498175 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0473589 |
| CCNL1 | cyclin L1 | 0.0468263 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0462237 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0459642 |
| PLEC | plectin | 0.0453855 |
| MSN | moesin | 0.0451279 |
| MXD1 | MAX dimerization protein 1 | 0.0435253 |
| WASF2 | WAS protein family, member 2 | 0.0434757 |
| SETD5 | SET domain containing 5 | 0.0434025 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0431144 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0426033 |
| CALR | calreticulin | 0.0424534 |
| EZR | ezrin | 0.0417181 |
| TMF1 | TATA element modulatory factor 1 | 0.0410352 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.040221 |
| LDHA | lactate dehydrogenase A | 0.0402203 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0401328 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0386088 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0378901 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0369931 |
| KRT18 | keratin 18, type I | 0.0363272 |
| PCBP2 | poly(rC) binding protein 2 | 0.0357834 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0355977 |
| RCOR1 | REST corepressor 1 | 0.0354238 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.035076 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0348719 |
| PGK1 | phosphoglycerate kinase 1 | 0.0347699 |
| PKM | pyruvate kinase, muscle | 0.0344557 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0344168 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0343105 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0341834 |
| SPAG9 | sperm associated antigen 9 | 0.0338439 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0337608 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0333863 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0332623 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0331119 |
| RIOK3 | RIO kinase 3 | 0.0330901 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0324853 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0323581 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0323224 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0320847 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0320581 |
| UBC | ubiquitin C | 0.0314668 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0313204 |
| HLA-B | major histocompatibility complex, class I, B | 0.0311384 |
| SLMAP | sarcolemma associated protein | 0.0310936 |
| RHOA | ras homolog family member A | 0.0310702 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0305499 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0305489 |
| HELZ | helicase with zinc finger | 0.0299356 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0298907 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0297297 |
| TPM3 | tropomyosin 3 | 0.0293017 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0292605 |
| HLA-A | major histocompatibility complex, class I, A | 0.0291949 |
| FLNB | filamin B, beta | 0.0291736 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0291207 |
| TFG | TRK-fused gene | 0.0288851 |
| FOSL1 | FOS-like antigen 1 | 0.0285042 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0284656 |
| RBM25 | RNA binding motif protein 25 | 0.0284535 |
| GOLGA4 | golgin A4 | 0.0282109 |
| PUM1 | pumilio RNA-binding family member 1 | 0.027935 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0279176 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0273393 |
| YTHDC1 | YTH domain containing 1 | 0.0272765 |
| DSTN | destrin (actin depolymerizing factor) | 0.0268256 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0267641 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0266021 |
| NUP58 | nucleoporin 58 | 0.0263212 |
| TOP1 | topoisomerase (DNA) I | 0.0260275 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.182218 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0710552 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.067463 |
| LAMC2 | laminin, gamma 2 | -0.0584453 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.058301 |
| EFNA5 | ephrin-A5 | -0.0510354 |
| RPL35A | ribosomal protein L35a | -0.0499774 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.047865 |
| RPL34 | ribosomal protein L34 | -0.0416658 |
| NAV2 | neuron navigator 2 | -0.0381027 |
| FN1 | fibronectin 1 | -0.0367073 |
| RPLP1 | ribosomal protein, large, P1 | -0.0361359 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0346539 |
| RPL30 | ribosomal protein L30 | -0.0329025 |
| ACTG1 | actin gamma 1 | -0.0312678 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.031015 |
| RPL23 | ribosomal protein L23 | -0.0300807 |
| RPLP0 | ribosomal protein, large, P0 | -0.0293326 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0291635 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0290364 |
| RPS24 | ribosomal protein S24 | -0.0286938 |
| RPL9 | ribosomal protein L9 | -0.028372 |
| RPS8 | ribosomal protein S8 | -0.0268992 |
| TXNRD1 | thioredoxin reductase 1 | -0.026517 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0254948 |
| AHNAK | AHNAK nucleoprotein | -0.025116 |
| RPL4 | ribosomal protein L4 | -0.0247464 |
| OSMR | oncostatin M receptor | -0.0242228 |
| ATXN1 | ataxin 1 | -0.0240156 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0230155 |
| FHIT | fragile histidine triad | -0.0229501 |
| RPL37 | ribosomal protein L37 | -0.0223443 |
| SDC4 | syndecan 4 | -0.0217497 |
| RACK1 | receptor for activated C kinase 1 | -0.0217222 |
| KIAA1217 | KIAA1217 | -0.0214448 |
| SYT1 | synaptotagmin I | -0.0205246 |
| VCL | vinculin | -0.0204076 |
| STEAP4 | STEAP family member 4 | -0.0201829 |
| PALLD | palladin, cytoskeletal associated protein | -0.0201157 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0199679 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0191583 |
| RPS21 | ribosomal protein S21 | -0.018991 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0187854 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0184593 |
| ETV6 | ets variant 6 | -0.0182798 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0178319 |
| RPL38 | ribosomal protein L38 | -0.0178063 |
| RPS19 | ribosomal protein S19 | -0.0174837 |
| EGFR | epidermal growth factor receptor | -0.0174687 |
| PLSCR1 | phospholipid scramblase 1 | -0.017374 |
| PEG10 | paternally expressed 10 | -0.0170891 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0170147 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0169813 |
| SMAD3 | SMAD family member 3 | -0.0166455 |
| RAD51B | RAD51 paralog B | -0.0164868 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0163356 |
| SMYD3 | SET and MYND domain containing 3 | -0.0162191 |
| RPL12 | ribosomal protein L12 | -0.0157472 |
| FBXO34 | F-box protein 34 | -0.0156329 |
| KRT7 | keratin 7, type II | -0.0154716 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0153826 |
| RUNX1 | runt-related transcription factor 1 | -0.0153479 |
| RPS23 | ribosomal protein S23 | -0.0149796 |
| RPS20 | ribosomal protein S20 | -0.0149565 |
| RPL6 | ribosomal protein L6 | -0.0149479 |
| RPS27A | ribosomal protein S27a | -0.0148829 |
| RPL27 | ribosomal protein L27 | -0.0147997 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0145936 |
| CAB39 | calcium binding protein 39 | -0.014579 |
| VGLL3 | vestigial-like family member 3 | -0.0145022 |
| RPL26 | ribosomal protein L26 | -0.0142386 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0142243 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0141745 |
| RPL14 | ribosomal protein L14 | -0.0141304 |
| TUBB | tubulin, beta class I | -0.0141085 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0138018 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0137958 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0137895 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.013711 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0134808 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0134135 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0134129 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0133317 |
| SQSTM1 | sequestosome 1 | -0.0132941 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.013271 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0131598 |
| KLHL5 | kelch-like family member 5 | -0.0128662 |
| RIGI | RNA sensor RIG-I | -0.0127842 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0126337 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0126043 |
| HMGB1 | high mobility group box 1 | -0.0123437 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0122779 |
| KLF12 | Kruppel-like factor 12 | -0.0122587 |
| MAP4 | microtubule-associated protein 4 | -0.0121749 |
| MAP1B | microtubule-associated protein 1B | -0.0120171 |
| ARF1 | ADP-ribosylation factor 1 | -0.011967 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.01191 |
| TBCA | tubulin folding cofactor A | -0.0118983 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0118892 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0117049 |
