Tirabrutinib (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.109019
FN1 fibronectin 1 0.103697
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0874386
EEF2 eukaryotic translation elongation factor 2 0.0768647
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0646322
PTMA prothymosin, alpha 0.0495717
TPT1 tumor protein, translationally-controlled 1 0.0480312
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0479766
VIM vimentin 0.0471426
CANX calnexin 0.0430631
MCL1 myeloid cell leukemia 1 0.0430159
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0375343
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0369702
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0366577
SPAG9 sperm associated antigen 9 0.0353985
SOD2 superoxide dismutase 2, mitochondrial 0.0340884
RPS6 ribosomal protein S6 0.033747
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0330886
EIF1 eukaryotic translation initiation factor 1 0.0330797
FTH1 ferritin, heavy polypeptide 1 0.0320723
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0299925
GOLGA4 golgin A4 0.0291478
TM4SF1 transmembrane 4 L six family member 1 0.0286831
NAP1L1 nucleosome assembly protein 1-like 1 0.0280812
B2M beta-2-microglobulin 0.0280365
STC1 stanniocalcin 1 0.0275165
EZR ezrin 0.0271768
SFTPA2 surfactant protein A2 0.0271107
PRRC2C proline-rich coiled-coil 2C 0.0270064
NDRG1 N-myc downstream regulated 1 0.0267171
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0264966
RPS4X ribosomal protein S4, X-linked 0.0264773
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0263041
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0257446
HLA-A major histocompatibility complex, class I, A 0.0255476
DDIT4 DNA-damage-inducible transcript 4 0.0253511
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0253239
GARS1 glycyl-tRNA synthetase 1 0.0247603
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0244662
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0244092
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0243607
RPL19 ribosomal protein L19 0.0236929
RPS12 ribosomal protein S12 0.0236717
INHBA inhibin, beta A 0.023085
CD44 CD44 molecule (Indian blood group) 0.0229136
NAMPT nicotinamide phosphoribosyltransferase 0.0223175
ANXA1 annexin A1 0.022315
PGK1 phosphoglycerate kinase 1 0.0221229
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.021783
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0217493
BZW1 basic leucine zipper and W2 domains 1 0.0215239
RPL12 ribosomal protein L12 0.0213225
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0211405
HLA-B major histocompatibility complex, class I, B 0.0208966
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0207599
IL6 interleukin 6 0.0203486
FLNB filamin B, beta 0.020258
SQSTM1 sequestosome 1 0.0201948
PDIA6 protein disulfide isomerase family A, member 6 0.0201555
RPL37A ribosomal protein L37a 0.0198323
FMNL2 formin-like 2 0.0197777
KMT2E lysine (K)-specific methyltransferase 2E 0.0195019
RAB7A RAB7A, member RAS oncogene family 0.019393
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0190466
NUP58 nucleoporin 58 0.0188711
TNIP1 TNFAIP3 interacting protein 1 0.0187692
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0184748
WDR43 WD repeat domain 43 0.0182501
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0181217
WARS1 tryptophanyl-tRNA synthetase 1 0.0179999
IGFBP3 insulin-like growth factor binding protein 3 0.0179894
RPL31 ribosomal protein L31 0.0179246
ELL2 elongation factor, RNA polymerase II, 2 0.0178202
COPA coatomer protein complex, subunit alpha 0.0175758
KDM3A lysine (K)-specific demethylase 3A 0.0174158
ERRFI1 ERBB receptor feedback inhibitor 1 0.0173443
BHLHE40 basic helix-loop-helix family, member e40 0.017186
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0171581
RPS8 ribosomal protein S8 0.0170531
ITPRID2 ITPR interacting domain containing 2 0.0168502
MXI1 MAX interactor 1, dimerization protein 0.0167968
FNIP1 folliculin interacting protein 1 0.0165117
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0164893
CALR calreticulin 0.0164118
CTBP2 C-terminal binding protein 2 0.0163192
PDIA3 protein disulfide isomerase family A, member 3 0.0159132
STC2 stanniocalcin 2 0.0158794
EIF4A2 eukaryotic translation initiation factor 4A2 0.0157587
NBEAL1 neurobeachin-like 1 0.0156701
AKAP12 A kinase (PRKA) anchor protein 12 0.015648
RPL11 ribosomal protein L11 0.0154944
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0153984
TPM3 tropomyosin 3 0.0150339
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0149988
WDR45B WD repeat domain 45B 0.0148242
UBC ubiquitin C 0.0148108
DUSP5 dual specificity phosphatase 5 0.0147363
YBX3 Y box binding protein 3 0.0147192
RIOK3 RIO kinase 3 0.0147157
RPS23 ribosomal protein S23 0.0147103

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.121832
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0891105
EFNA5 ephrin-A5 -0.0770935
COL5A2 collagen, type V, alpha 2 -0.0648738
PSD3 pleckstrin and Sec7 domain containing 3 -0.0634039
NRCAM neuronal cell adhesion molecule -0.0628857
ASPH aspartate beta-hydroxylase -0.0606949
NALF1 NALCN channel auxiliary factor 1 -0.047136
COL8A1 collagen, type VIII, alpha 1 -0.0431035
PDE10A phosphodiesterase 10A -0.0415598
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0367254
PCBP3 poly(rC) binding protein 3 -0.036019
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.035557
PM20D1 peptidase M20 domain containing 1 -0.0309174
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0299842
GDA guanine deaminase -0.0286977
PDLIM5 PDZ and LIM domain 5 -0.0279734
DST dystonin -0.0273121
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0261272
NPAS2 neuronal PAS domain protein 2 -0.0259964
SMYD3 SET and MYND domain containing 3 -0.0259331
COL4A5 collagen, type IV, alpha 5 -0.0256541
DOCK4 dedicator of cytokinesis 4 -0.0255711
GRAMD1B GRAM domain containing 1B -0.0252226
CTSC cathepsin C -0.0236494
TXNRD1 thioredoxin reductase 1 -0.0235763
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.022302
NEK7 NIMA-related kinase 7 -0.0220119
RTN1 reticulon 1 -0.021165
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0210426
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0192196
PRKN parkin RBR E3 ubiquitin protein ligase -0.0191187
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0188215
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0175675
TNPO1 transportin 1 -0.0173018
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0167999
COL4A6 collagen, type IV, alpha 6 -0.0159797
GPRIN3 GPRIN family member 3 -0.0156758
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0154239
PALLD palladin, cytoskeletal associated protein -0.0153902
ATXN1 ataxin 1 -0.0153619
P3H2 prolyl 3-hydroxylase 2 -0.0149946
NHSL1 NHS-like 1 -0.0143602
VCL vinculin -0.0143518
FNDC3B fibronectin type III domain containing 3B -0.0143435
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0140534
PTGR1 prostaglandin reductase 1 -0.0139015
GLIS3 GLIS family zinc finger 3 -0.0135381
DISP1 dispatched homolog 1 (Drosophila) -0.0129978
AOPEP aminopeptidase O (putative) -0.0129592
BCAR3 breast cancer anti-estrogen resistance 3 -0.0128748
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0125363
PBX1 pre-B-cell leukemia homeobox 1 -0.0123858
SLF1 SMC5-SMC6 complex localization factor 1 -0.0122607
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0121026
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0120688
ARHGAP29 Rho GTPase activating protein 29 -0.0119362
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.011767
WWTR1 WW domain containing transcription regulator 1 -0.0117222
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0112127
BDNF brain-derived neurotrophic factor -0.0111482
EPHA4 EPH receptor A4 -0.0108207
ALPK2 alpha-kinase 2 -0.0108195
DPYD dihydropyrimidine dehydrogenase -0.0108025
TUSC3 tumor suppressor candidate 3 -0.0106208
NCOA7 nuclear receptor coactivator 7 -0.0105551
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0104984
CENPF centromere protein F, 350/400kDa -0.0103695
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0102633
PRKD3 protein kinase D3 -0.0101701
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.0101119
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.0101013
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.00991705
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.00989689
MYOF myoferlin -0.0098487
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.00983274
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00967691
EVA1C eva-1 homolog C (C. elegans) -0.00941368
MAML3 mastermind-like 3 (Drosophila) -0.00920071
ADGRB3 adhesion G protein-coupled receptor B3 -0.00917834
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0090492
NFE2L2 nuclear factor, erythroid 2-like 2 -0.00903248
BCAS3 breast carcinoma amplified sequence 3 -0.00896948
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00892206
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.00888603
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.00885542
AGFG1 ArfGAP with FG repeats 1 -0.00871575
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.00844265
TGFB2 transforming growth factor, beta 2 -0.00839802
RABGAP1L RAB GTPase activating protein 1-like -0.0082952
METTL15 methyltransferase like 15 -0.00822502
DCLK2 doublecortin-like kinase 2 -0.00811608
MEF2C myocyte enhancer factor 2C -0.00808883
MFF mitochondrial fission factor -0.00808371
ANTXR1 anthrax toxin receptor 1 -0.00807312
WDFY2 WD repeat and FYVE domain containing 2 -0.00799841
RPH3AL rabphilin 3A-like (without C2 domains) -0.00799398
GPC6 glypican 6 -0.00798159
CD109 CD109 molecule -0.00789902
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.00780863