Tirabrutinib (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

183 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.113789
FTH1 ferritin, heavy polypeptide 1 0.108501
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108239
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108059
LOC112694756 uncharaterized LOC112694756 0.101307
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0956319
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0947266
RTN4 reticulon 4 0.0939665
WAC WW domain containing adaptor with coiled-coil 0.0896113
MACF1 microtubule-actin crosslinking factor 1 0.0857169
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0822834
DST dystonin 0.0758684
RAD51B RAD51 paralog B 0.075219
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0752135
POTEF POTE ankyrin domain family, member F 0.070115
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0691527
TPT1 tumor protein, translationally-controlled 1 0.0688634
PDE10A phosphodiesterase 10A 0.0593581
ZBTB20 zinc finger and BTB domain containing 20 0.058183
KMT2E lysine (K)-specific methyltransferase 2E 0.053794
BIRC6 baculoviral IAP repeat containing 6 0.0514616
EEF2 eukaryotic translation elongation factor 2 0.0512125
NAMPT nicotinamide phosphoribosyltransferase 0.049479
MATR3 matrin 3 0.047558
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0471223
VMP1 vacuole membrane protein 1 0.0444932
RUNX1 runt-related transcription factor 1 0.0442581
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0429259
EIF1 eukaryotic translation initiation factor 1 0.0427589
FGF14 fibroblast growth factor 14 0.0426593
TXNRD1 thioredoxin reductase 1 0.0423186
TBC1D5 TBC1 domain family, member 5 0.0407575
PTMA prothymosin, alpha 0.040535
GARS1 glycyl-tRNA synthetase 1 0.040137
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0399258
VIM vimentin 0.0398839
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0389376
TENM3 teneurin transmembrane protein 3 0.0389325
PRRC2C proline-rich coiled-coil 2C 0.0387212
NALF1 NALCN channel auxiliary factor 1 0.0378436
RPL11 ribosomal protein L11 0.0376787
GOLGA4 golgin A4 0.0367761
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0366788
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0359963
RPS6 ribosomal protein S6 0.0337957
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0337493
VCL vinculin 0.0308344
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0303843
ZNF292 zinc finger protein 292 0.0297112
PGK1 phosphoglycerate kinase 1 0.0281623
ANXA2 annexin A2 0.0272468
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0256184
KTN1 kinectin 1 (kinesin receptor) 0.0254963
RAB1A RAB1A, member RAS oncogene family 0.0254349
RORA RAR-related orphan receptor A 0.0253506
KMT2C lysine (K)-specific methyltransferase 2C 0.0251696
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0242893
NKD1 naked cuticle homolog 1 (Drosophila) 0.0225623
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.02253
GPC6 glypican 6 0.0220829
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0205478
NAP1L1 nucleosome assembly protein 1-like 1 0.0201485
AKAP12 A kinase (PRKA) anchor protein 12 0.0194222
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.019166
LPP LIM domain containing preferred translocation partner in lipoma 0.0188632
IQGAP1 IQ motif containing GTPase activating protein 1 0.0179209
DSCAM Down syndrome cell adhesion molecule 0.0160535
PKM pyruvate kinase, muscle 0.0136232
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0125991
FMNL2 formin-like 2 0.0123744
PTK2 protein tyrosine kinase 2 0.0122495
NFIA nuclear factor I/A 0.0115513
FNIP1 folliculin interacting protein 1 0.0114294
RAB10 RAB10, member RAS oncogene family 0.010834
SMYD3 SET and MYND domain containing 3 0.00939207
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.00774967
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00668513
GPBP1 GC-rich promoter binding protein 1 0.0065451
ARID4B AT rich interactive domain 4B (RBP1-like) 0.00647966
PSD3 pleckstrin and Sec7 domain containing 3 0.00352264
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00106698
JMJD1C jumonji domain containing 1C 8.87513E-4
RNF145 ring finger protein 145 2.85889E-4

decreased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A -0.182507
EGFR epidermal growth factor receptor -0.12673
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.115809
TIMP3 TIMP metallopeptidase inhibitor 3 -0.106603
FLNB filamin B, beta -0.104269
ITCH itchy E3 ubiquitin protein ligase -0.0998031
STC1 stanniocalcin 1 -0.094628
NRIP1 nuclear receptor interacting protein 1 -0.0923867
FNDC3B fibronectin type III domain containing 3B -0.092376
PDE8A phosphodiesterase 8A -0.0923757
NCAM1 neural cell adhesion molecule 1 -0.08771
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0836659
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0811657
MYOF myoferlin -0.0751951
TRIO trio Rho guanine nucleotide exchange factor -0.0733336
INHBA inhibin, beta A -0.0709679
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0667292
XPO1 exportin 1 -0.064766
OGA O-GlcNAcase -0.0609381
SLTM SAFB-like, transcription modulator -0.060261
HELZ helicase with zinc finger -0.0600579
MT2A metallothionein 2A -0.0600518
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0590498
CALU calumenin -0.0566839
DOCK4 dedicator of cytokinesis 4 -0.0565601
MYO1E myosin IE -0.0556546
ELL2 elongation factor, RNA polymerase II, 2 -0.0538518
FNDC3A fibronectin type III domain containing 3A -0.0530675
SEC31A SEC31 homolog A (S. cerevisiae) -0.0527864
SPAG9 sperm associated antigen 9 -0.050416
ANKRD12 ankyrin repeat domain 12 -0.0501143
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0495359
COL6A2 collagen, type VI, alpha 2 -0.0486408
KCMF1 potassium channel modulatory factor 1 -0.0480579
LAMA4 laminin, alpha 4 -0.0473659
ENO1 enolase 1, (alpha) -0.044624
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0443616
LMAN1 lectin, mannose-binding, 1 -0.0431303
PDLIM5 PDZ and LIM domain 5 -0.042848
ASPH aspartate beta-hydroxylase -0.0417937
IGF2 insulin-like growth factor 2 -0.0410028
CLTC clathrin, heavy chain (Hc) -0.0403601
HM13 histocompatibility (minor) 13 -0.0403385
PIBF1 progesterone immunomodulatory binding factor 1 -0.0403249
AFF4 AF4/FMR2 family, member 4 -0.0387599
TPM4 tropomyosin 4 -0.03424
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0339037
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0334741
ANKRD11 ankyrin repeat domain 11 -0.033209
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0331898
RAB7A RAB7A, member RAS oncogene family -0.0327632
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0324765
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0316967
ALCAM activated leukocyte cell adhesion molecule -0.0316813
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0316699
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0307905
FN1 fibronectin 1 -0.0307681
PRKCA protein kinase C, alpha -0.0302937
PRELID2 PRELI domain containing 2 -0.0294644
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0293895
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0292136
SMC5 structural maintenance of chromosomes 5 -0.0289682
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0257255
KDM4C lysine (K)-specific demethylase 4C -0.0252555
PDE4D phosphodiesterase 4D, cAMP-specific -0.0247968
EFNA5 ephrin-A5 -0.0230026
TTC17 tetratricopeptide repeat domain 17 -0.0214569
AKAP13 A kinase (PRKA) anchor protein 13 -0.0203512
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0195632
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0185635
RPS8 ribosomal protein S8 -0.0183903
AKAP9 A kinase (PRKA) anchor protein 9 -0.0170947
EXT1 exostosin glycosyltransferase 1 -0.0169821
MARCHF6 membrane associated ring-CH-type finger 6 -0.0163258
EMP1 epithelial membrane protein 1 -0.0162885
RSF1 remodeling and spacing factor 1 -0.0149642
KDM6A lysine (K)-specific demethylase 6A -0.0149167
HDLBP high density lipoprotein binding protein -0.0141637
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0134512
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0130268
WNK1 WNK lysine deficient protein kinase 1 -0.0127267
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0125212
MEF2A myocyte enhancer factor 2A -0.0120731
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0110791
RPLP1 ribosomal protein, large, P1 -0.011042
GOLGB1 golgin B1 -0.0103533
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0103457
SBF2 SET binding factor 2 -0.0098093
LDHA lactate dehydrogenase A -0.00936123
RBM39 RNA binding motif protein 39 -0.00921227
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00737334
MAML2 mastermind-like 2 (Drosophila) -0.00725146
RB1CC1 RB1-inducible coiled-coil 1 -0.0069538
TTC3 tetratricopeptide repeat domain 3 -0.00660079
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00642416
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00544907
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0053971
ESYT2 extended synaptotagmin-like protein 2 -0.0050426
CANX calnexin -0.00491774
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.00424596