| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0738468 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.073776 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.070238 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0656609 |
| SPAG9 | sperm associated antigen 9 | 0.0628088 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0599577 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.05914 |
| FN1 | fibronectin 1 | 0.0584625 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0571988 |
| RPL19 | ribosomal protein L19 | 0.0549232 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0539435 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0539041 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0524461 |
| YBX1 | Y box binding protein 1 | 0.0485096 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0477191 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0476387 |
| EMP1 | epithelial membrane protein 1 | 0.0473152 |
| B2M | beta-2-microglobulin | 0.0466918 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0463667 |
| CALR | calreticulin | 0.0459315 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0459164 |
| PTMA | prothymosin, alpha | 0.0454009 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0446203 |
| GNAS | GNAS complex locus | 0.0438661 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0437411 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0426716 |
| EFNA5 | ephrin-A5 | 0.0420674 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0419747 |
| AHNAK | AHNAK nucleoprotein | 0.0399421 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.039787 |
| ASPH | aspartate beta-hydroxylase | 0.0397561 |
| RPLP0 | ribosomal protein, large, P0 | 0.0394155 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0392838 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0384313 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0364799 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0360752 |
| NDRG1 | N-myc downstream regulated 1 | 0.0355648 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0354587 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0354513 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0338916 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0337675 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0335757 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.033459 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0334023 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.03318 |
| RPS4X | ribosomal protein S4, X-linked | 0.0330872 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0324725 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0317868 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0313782 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0312995 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0310824 |
| FTL | ferritin, light polypeptide | 0.0309016 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0304772 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0304222 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0303461 |
| FBL | fibrillarin | 0.0299985 |
| TMSB10 | thymosin beta 10 | 0.0299256 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0298405 |
| RTN4 | reticulon 4 | 0.0297432 |
| MTF2 | metal response element binding transcription factor 2 | 0.0288141 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0287317 |
| FBXO11 | F-box protein 11 | 0.0285594 |
| PTK2 | protein tyrosine kinase 2 | 0.0283318 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0278423 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0277748 |
| PHIP | pleckstrin homology domain interacting protein | 0.0277699 |
| RPL35A | ribosomal protein L35a | 0.0275093 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0272463 |
| RPL31 | ribosomal protein L31 | 0.0271224 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0270817 |
| RPS24 | ribosomal protein S24 | 0.0269423 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0267773 |
| CBX3 | chromobox homolog 3 | 0.0267295 |
| PGK1 | phosphoglycerate kinase 1 | 0.0266568 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0265651 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0264697 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0264214 |
| RACK1 | receptor for activated C kinase 1 | 0.0264212 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0262944 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0262813 |
| TJP1 | tight junction protein 1 | 0.0261761 |
| GAB2 | GRB2-associated binding protein 2 | 0.0260112 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0257814 |
| PRR11 | proline rich 11 | 0.0256017 |
| TCEAL9 | transcription elongation factor A like 9 | 0.0254917 |
| TUBB | tubulin, beta class I | 0.0254057 |
| RHOA | ras homolog family member A | 0.0251761 |
| DEK | DEK proto-oncogene | 0.0250509 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0250417 |
| SOX2 | SRY (sex determining region Y)-box 2 | 0.0249603 |
| RPL23 | ribosomal protein L23 | 0.024911 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0247713 |
| RPL34 | ribosomal protein L34 | 0.0246411 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0245845 |
| SETD5 | SET domain containing 5 | 0.0243029 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0242148 |
| ANXA2 | annexin A2 | 0.0241537 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0240818 |
| RPL9 | ribosomal protein L9 | 0.0239933 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0238992 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0760237 |
| COL5A2 | collagen, type V, alpha 2 | -0.0744381 |
| VIM | vimentin | -0.0689436 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0619592 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0618205 |
| CLTC | clathrin, heavy chain (Hc) | -0.053913 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0533496 |
| DST | dystonin | -0.052721 |
| ENAH | enabled homolog (Drosophila) | -0.0488714 |
| HDAC9 | histone deacetylase 9 | -0.04481 |
| NTM | neurotrimin | -0.0430523 |
| ITGAV | integrin, alpha V | -0.0427089 |
| H1-4 | H1.4 linker histone, cluster member | -0.0419151 |
| GPC3 | glypican 3 | -0.0410044 |
| ZNF292 | zinc finger protein 292 | -0.0408515 |
| SNX6 | sorting nexin 6 | -0.0404089 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0393509 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0375824 |
| NEBL | nebulette | -0.0368243 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0367226 |
| APP | amyloid beta (A4) precursor protein | -0.0359819 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.0355752 |
| FOXP2 | forkhead box P2 | -0.0344796 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.034429 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0342907 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0327122 |
| SMYD3 | SET and MYND domain containing 3 | -0.0321976 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0319281 |
| RASAL2 | RAS protein activator like 2 | -0.0319155 |
| SUCO | SUN domain containing ossification factor | -0.0319039 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0315613 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0315243 |
| PDCD5 | programmed cell death 5 | -0.0313268 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0312682 |
| CADM2 | cell adhesion molecule 2 | -0.0309126 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0305879 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.0304934 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0299796 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0293705 |
| H1-5 | H1.5 linker histone, cluster member | -0.0293353 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0292109 |
| VGLL4 | vestigial-like family member 4 | -0.027526 |
| PDS5A | PDS5 cohesin associated factor A | -0.0270596 |
| IPO11 | importin 11 | -0.0270501 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.027017 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0269499 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0269164 |
| ANXA1 | annexin A1 | -0.0268427 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0266508 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0264352 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.026421 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0260364 |
| KIF4A | kinesin family member 4A | -0.0259325 |
| SP3 | Sp3 transcription factor | -0.0257511 |
| ENO1 | enolase 1, (alpha) | -0.0257208 |
| SIK3 | SIK family kinase 3 | -0.0256954 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0256169 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0255981 |
| POTEF | POTE ankyrin domain family, member F | -0.0249446 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0248774 |
| SET | SET nuclear proto-oncogene | -0.0248667 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0248197 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.024786 |
| CEP192 | centrosomal protein 192kDa | -0.0246212 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.02456 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0243801 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0242772 |
| KIF1B | kinesin family member 1B | -0.0241624 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0240388 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0239284 |
| FNDC3B | fibronectin type III domain containing 3B | -0.023745 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0235162 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0234345 |
| MDN1 | MDN1, midasin homolog (yeast) | -0.0233947 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0233944 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0233101 |
| LATS2 | large tumor suppressor kinase 2 | -0.0231732 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.0231636 |
| CRY1 | cryptochrome circadian clock 1 | -0.0231432 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0230194 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0229297 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0227973 |
| TXNRD1 | thioredoxin reductase 1 | -0.022777 |
| MEIS2 | Meis homeobox 2 | -0.0226842 |
| TUT4 | terminal uridylyl transferase 4 | -0.0226817 |
| ZNF608 | zinc finger protein 608 | -0.0224798 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0223709 |
| RHEB | Ras homolog enriched in brain | -0.0222786 |
| USP53 | ubiquitin specific peptidase 53 | -0.0221696 |
| RPS18 | ribosomal protein S18 | -0.0221083 |
| RPS16 | ribosomal protein S16 | -0.0219697 |
| PLPP1 | phospholipid phosphatase 1 | -0.0219542 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0219321 |
| SHROOM3 | shroom family member 3 | -0.0218941 |
| KIAA1328 | KIAA1328 | -0.0218505 |
| ITSN2 | intersectin 2 | -0.0216982 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0216023 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0215933 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0213708 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0213513 |
