Tirabrutinib (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.104254
TXNRD1 thioredoxin reductase 1 0.0765475
ERRFI1 ERBB receptor feedback inhibitor 1 0.0695761
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0640849
MYH9 myosin, heavy chain 9, non-muscle 0.0639318
PABPC1 poly(A) binding protein, cytoplasmic 1 0.062818
ANXA2 annexin A2 0.0564434
JMJD1C jumonji domain containing 1C 0.0554562
SFTPA2 surfactant protein A2 0.0553116
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0541489
SMAD3 SMAD family member 3 0.0539738
EEF2 eukaryotic translation elongation factor 2 0.0497942
ACTN4 actinin, alpha 4 0.0497028
GARS1 glycyl-tRNA synthetase 1 0.0440094
ARRDC3 arrestin domain containing 3 0.0434626
MATR3 matrin 3 0.0423382
YBX1 Y box binding protein 1 0.0401094
ZNF292 zinc finger protein 292 0.0391837
SPAG9 sperm associated antigen 9 0.0386825
OGA O-GlcNAcase 0.0359944
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0357558
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0347845
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.033635
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0327072
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.032251
MLF1 myeloid leukemia factor 1 0.0317984
NAP1L1 nucleosome assembly protein 1-like 1 0.0314408
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0309038
TMEM41B transmembrane protein 41B 0.0305444
ANLN anillin, actin binding protein 0.0300358
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0300096
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0296861
TRA2A transformer 2 alpha homolog (Drosophila) 0.0290906
RPS4X ribosomal protein S4, X-linked 0.0287676
TPD52 tumor protein D52 0.0287087
XPO1 exportin 1 0.0281044
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0279225
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.027783
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0272563
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0272311
MYOF myoferlin 0.027109
APLP2 amyloid beta (A4) precursor-like protein 2 0.0270098
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0268433
FXR1 fragile X mental retardation, autosomal homolog 1 0.0266322
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0264877
KDM3A lysine (K)-specific demethylase 3A 0.026285
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0252765
MED13L mediator complex subunit 13-like 0.0246469
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0245588
APP amyloid beta (A4) precursor protein 0.0245274
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0244446
TNIP1 TNFAIP3 interacting protein 1 0.0238741
RLF rearranged L-myc fusion 0.0238428
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0238329
FTH1 ferritin, heavy polypeptide 1 0.0235767
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0232608
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0229557
NAMPT nicotinamide phosphoribosyltransferase 0.0229518
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0229323
CALU calumenin 0.0228915
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0228547
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0227764
HDLBP high density lipoprotein binding protein 0.0227405
NUP58 nucleoporin 58 0.0226923
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0225997
DGKD diacylglycerol kinase, delta 130kDa 0.0224939
PLEC plectin 0.0223374
GOLGA4 golgin A4 0.0222062
CCNL1 cyclin L1 0.0218706
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0218302
SNX14 sorting nexin 14 0.0216649
IPO7 importin 7 0.0216571
UBE2O ubiquitin-conjugating enzyme E2O 0.0216203
EIF4A2 eukaryotic translation initiation factor 4A2 0.0213525
TSC22D2 TSC22 domain family, member 2 0.0212062
ATP13A3 ATPase type 13A3 0.0211198
KMT2A lysine (K)-specific methyltransferase 2A 0.0209902
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.020936
AFDN afadin, adherens junction formation factor 0.0208864
SBNO1 strawberry notch homolog 1 (Drosophila) 0.02084
FLNB filamin B, beta 0.0208348
EIF4A1 eukaryotic translation initiation factor 4A1 0.02073
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0205154
BIRC2 baculoviral IAP repeat containing 2 0.0204494
RBM25 RNA binding motif protein 25 0.0204171
AHNAK AHNAK nucleoprotein 0.0202499
CKAP5 cytoskeleton associated protein 5 0.0201037
RUNX1 runt-related transcription factor 1 0.0200076
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0199734
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0198194
SUCO SUN domain containing ossification factor 0.0198032
ECT2 epithelial cell transforming 2 0.0195791
SAMD4B sterile alpha motif domain containing 4B 0.0193879
NOP58 NOP58 ribonucleoprotein 0.0193287
ICAM1 intercellular adhesion molecule 1 0.0190728
USP3 ubiquitin specific peptidase 3 0.018855
MFGE8 milk fat globule-EGF factor 8 protein 0.0185717
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0184464
MARCHF6 membrane associated ring-CH-type finger 6 0.0184365
KMT2C lysine (K)-specific methyltransferase 2C 0.01833

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.238742
VIM vimentin -0.128437
VCL vinculin -0.116533
PTMA prothymosin, alpha -0.107635
RPL35A ribosomal protein L35a -0.0994922
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0817216
FTL ferritin, light polypeptide -0.060999
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0607456
TMSB10 thymosin beta 10 -0.0555862
RPLP2 ribosomal protein, large, P2 -0.0541599
RPS8 ribosomal protein S8 -0.0511209
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0505475
RPL37A ribosomal protein L37a -0.0475306
THSD4 thrombospondin, type I, domain containing 4 -0.0427299
RPS25 ribosomal protein S25 -0.041307
EGR1 early growth response 1 -0.0364017
UPP1 uridine phosphorylase 1 -0.0353109
RPS24 ribosomal protein S24 -0.0342628
INTS6 integrator complex subunit 6 -0.0341642
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0325703
RPS27A ribosomal protein S27a -0.0318923
RPS23 ribosomal protein S23 -0.0315568
RPL31 ribosomal protein L31 -0.0313879
RPS12 ribosomal protein S12 -0.0307803
RPS29 ribosomal protein S29 -0.030394
CTSD cathepsin D -0.0302233
ATG7 autophagy related 7 -0.0297979
RPS13 ribosomal protein S13 -0.0294952
MCL1 myeloid cell leukemia 1 -0.0292075
RPS17 ribosomal protein S17 -0.0291338
WSB1 WD repeat and SOCS box containing 1 -0.028669
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0286025
RPLP1 ribosomal protein, large, P1 -0.0283841
AKAP12 A kinase (PRKA) anchor protein 12 -0.0279152
RPL37 ribosomal protein L37 -0.0278599
MACF1 microtubule-actin crosslinking factor 1 -0.0278023
RPS14 ribosomal protein S14 -0.0276807
EGFR epidermal growth factor receptor -0.0265847
RPS3 ribosomal protein S3 -0.025678
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0255007
TPM1 tropomyosin 1 (alpha) -0.025328
HMGA1 high mobility group AT-hook 1 -0.0252744
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0244249
HSPG2 heparan sulfate proteoglycan 2 -0.0241809
HMGA2 high mobility group AT-hook 2 -0.0237005
RPL9 ribosomal protein L9 -0.023307
SDK1 sidekick cell adhesion molecule 1 -0.0232557
RNF220 ring finger protein 220 -0.0232536
RPS10 ribosomal protein S10 -0.0231126
RPL38 ribosomal protein L38 -0.023017
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0229037
NPAS2 neuronal PAS domain protein 2 -0.0227158
SETX senataxin -0.0221948
RPL36A ribosomal protein L36a -0.0214466
RPL28 ribosomal protein L28 -0.0204016
TPT1 tumor protein, translationally-controlled 1 -0.0203876
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0201276
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0199506
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0198112
RPS6 ribosomal protein S6 -0.0195219
WWTR1 WW domain containing transcription regulator 1 -0.0194398
RPS20 ribosomal protein S20 -0.0185264
CUX1 cut-like homeobox 1 -0.0178655
RPS5 ribosomal protein S5 -0.0177247
ACTG1 actin gamma 1 -0.0176522
RSU1 Ras suppressor protein 1 -0.0175823
MYO1E myosin IE -0.0173462
TBCA tubulin folding cofactor A -0.0173043
UBAP2 ubiquitin associated protein 2 -0.0172573
ANKRD11 ankyrin repeat domain 11 -0.017179
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.0171506
MSRB3 methionine sulfoxide reductase B3 -0.0170452
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0167192
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0166911
RPL34 ribosomal protein L34 -0.016543
HM13 histocompatibility (minor) 13 -0.0164927
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0161443
LPP LIM domain containing preferred translocation partner in lipoma -0.0160556
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0159451
NHSL1 NHS-like 1 -0.0158666
PDLIM5 PDZ and LIM domain 5 -0.0158229
RPL5 ribosomal protein L5 -0.0157878
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0157162
EXT1 exostosin glycosyltransferase 1 -0.0155076
FBXO11 F-box protein 11 -0.0154932
TNS3 tensin 3 -0.0154701
RAD51B RAD51 paralog B -0.0154387
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0153225
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0151213
EHBP1 EH domain binding protein 1 -0.0150486
RPL23 ribosomal protein L23 -0.0149777
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0149219
RPS15 ribosomal protein S15 -0.0148399
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0144369
MYO10 myosin X -0.0143907
ENO2 enolase 2 (gamma, neuronal) -0.0141679
ZFAND3 zinc finger, AN1-type domain 3 -0.0141474
PFN1 profilin 1 -0.0140905
TPM4 tropomyosin 4 -0.0139721
RACK1 receptor for activated C kinase 1 -0.0139597