| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT18 | keratin 18, type I | 0.0845604 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0636239 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0503253 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0479534 |
| KRT17 | keratin 17, type I | 0.0398244 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0372655 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0371258 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0370939 |
| TGM2 | transglutaminase 2 | 0.0342436 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0339726 |
| GOLGA4 | golgin A4 | 0.0337834 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0336592 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0313644 |
| CALR | calreticulin | 0.0295085 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0276211 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0269547 |
| EZR | ezrin | 0.0267565 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0264863 |
| VEGFA | vascular endothelial growth factor A | 0.0254019 |
| CANX | calnexin | 0.0235233 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0233174 |
| NAV2 | neuron navigator 2 | 0.022442 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0224152 |
| MKI67 | marker of proliferation Ki-67 | 0.0224025 |
| EMP1 | epithelial membrane protein 1 | 0.0216409 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0214696 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0206484 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0205391 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0205133 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0201055 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0196097 |
| PLEC | plectin | 0.0195342 |
| SMAD3 | SMAD family member 3 | 0.0193285 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0191886 |
| ECT2 | epithelial cell transforming 2 | 0.0189932 |
| ITGB4 | integrin, beta 4 | 0.0189547 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0188961 |
| YBX1 | Y box binding protein 1 | 0.0181639 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0175515 |
| CCNL1 | cyclin L1 | 0.0175107 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0174316 |
| KRT8 | keratin 8, type II | 0.0171925 |
| FOSL1 | FOS-like antigen 1 | 0.0171148 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.016951 |
| SETD5 | SET domain containing 5 | 0.0169408 |
| CENPF | centromere protein F, 350/400kDa | 0.0169383 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0168476 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0166559 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0166541 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0164217 |
| DIAPH3 | diaphanous-related formin 3 | 0.0163598 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0162992 |
| DST | dystonin | 0.0161426 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0160985 |
| ANO6 | anoctamin 6 | 0.0159983 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0153954 |
| C3 | complement component 3 | 0.0152981 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0152857 |
| FLNA | filamin A, alpha | 0.0152136 |
| MYO6 | myosin VI | 0.0151122 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0150228 |
| BRD2 | bromodomain containing 2 | 0.0147876 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0146548 |
| DSPP | dentin sialophosphoprotein | 0.0146023 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0145559 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0143749 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0143361 |
| RPS4X | ribosomal protein S4, X-linked | 0.0143 |
| POTEF | POTE ankyrin domain family, member F | 0.0141686 |
| ANLN | anillin, actin binding protein | 0.0140749 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0139729 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0138568 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0138427 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0136962 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0136803 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0135656 |
| NDRG1 | N-myc downstream regulated 1 | 0.0134521 |
| RNF145 | ring finger protein 145 | 0.013241 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0132328 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0131665 |
| IRS2 | insulin receptor substrate 2 | 0.013134 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0129426 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0128967 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0128511 |
| SFTPA2 | surfactant protein A2 | 0.0128215 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.012735 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0127221 |
| HMGB2 | high mobility group box 2 | 0.0124882 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.012473 |
| FAM3C | family with sequence similarity 3, member C | 0.0124236 |
| TXNRD1 | thioredoxin reductase 1 | 0.0123878 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0123484 |
| CABIN1 | calcineurin binding protein 1 | 0.0122665 |
| ARRDC3 | arrestin domain containing 3 | 0.0122643 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0122235 |
| HDLBP | high density lipoprotein binding protein | 0.0122021 |
| SEPTIN9 | septin 9 | 0.0121953 |
| AHNAK | AHNAK nucleoprotein | 0.012192 |
| ANXA2 | annexin A2 | 0.0121133 |
| WWC1 | WW and C2 domain containing 1 | 0.0120325 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.0997687 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0578776 |
| TMSB4X | thymosin beta 4, X-linked | -0.0461343 |
| ACTG1 | actin gamma 1 | -0.0451735 |
| MUC4 | mucin 4, cell surface associated | -0.040347 |
| RPL35A | ribosomal protein L35a | -0.0388919 |
| LMO7 | LIM domain 7 | -0.0342059 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0312213 |
| PLSCR1 | phospholipid scramblase 1 | -0.0301945 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0300368 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0293897 |
| RNF213 | ring finger protein 213 | -0.0293074 |
| TPM4 | tropomyosin 4 | -0.0284064 |
| TMSB10 | thymosin beta 10 | -0.0278691 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.024839 |
| SYT14 | synaptotagmin XIV | -0.0243893 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.02242 |
| RPS8 | ribosomal protein S8 | -0.022281 |
| RIGI | RNA sensor RIG-I | -0.0217587 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0214854 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.020922 |
| RPL34 | ribosomal protein L34 | -0.0207094 |
| CD2AP | CD2-associated protein | -0.0206306 |
| MX2 | MX dynamin-like GTPase 2 | -0.0205725 |
| MUC20 | mucin 20, cell surface associated | -0.0204913 |
| HLA-B | major histocompatibility complex, class I, B | -0.0194664 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0191868 |
| RPS24 | ribosomal protein S24 | -0.0191479 |
| RPLP1 | ribosomal protein, large, P1 | -0.018907 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0187202 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0180902 |
| SP100 | SP100 nuclear antigen | -0.0180637 |
| LAMA4 | laminin, alpha 4 | -0.0178051 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0172532 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0168703 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0168272 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.016796 |
| RPL37A | ribosomal protein L37a | -0.0165994 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.015875 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.0155466 |
| HLA-E | major histocompatibility complex, class I, E | -0.0154561 |
| SULF2 | sulfatase 2 | -0.0150602 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0149635 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0148987 |
| OSMR | oncostatin M receptor | -0.0147496 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0146459 |
| ETV6 | ets variant 6 | -0.0144535 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0142701 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0139041 |
| RPS6 | ribosomal protein S6 | -0.0139039 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.013797 |
| PTMA | prothymosin, alpha | -0.013796 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0136769 |
| RPS29 | ribosomal protein S29 | -0.01352 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0135135 |
| IFI44 | interferon-induced protein 44 | -0.0133718 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0132229 |
| RPL37 | ribosomal protein L37 | -0.0131496 |
| RPL36A | ribosomal protein L36a | -0.0128994 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0128759 |
| ASS1 | argininosuccinate synthase 1 | -0.0128553 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0127513 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.01268 |
| EFNA5 | ephrin-A5 | -0.0125812 |
| RPL38 | ribosomal protein L38 | -0.0125062 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0123818 |
| RPL12 | ribosomal protein L12 | -0.0122301 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0121547 |
| RPS21 | ribosomal protein S21 | -0.0121256 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0120882 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0119746 |
| ZDHHC13 | zinc finger, DHHC-type containing 13 | -0.0119451 |
| PLAT | plasminogen activator, tissue | -0.0118921 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0115877 |
| TRIM56 | tripartite motif containing 56 | -0.0115208 |
| RPL30 | ribosomal protein L30 | -0.0115045 |
| RPS27A | ribosomal protein S27a | -0.0114196 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0114006 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0113077 |
| MX1 | MX dynamin-like GTPase 1 | -0.0113004 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0111148 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0110182 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0110013 |
| CD44 | CD44 molecule (Indian blood group) | -0.0109229 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0108506 |
| H1-0 | H1.0 linker histone | -0.0108221 |
| ACTN4 | actinin, alpha 4 | -0.0106785 |
| MEF2A | myocyte enhancer factor 2A | -0.0106673 |
| RPL31 | ribosomal protein L31 | -0.0105324 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0105027 |
| DSG2 | desmoglein 2 | -0.0104945 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0104638 |
| SVIL | supervillin | -0.0104162 |
| GNAS | GNAS complex locus | -0.0104082 |
| RRBP1 | ribosome binding protein 1 | -0.0103917 |
| REEP3 | receptor accessory protein 3 | -0.0103686 |
| RPL28 | ribosomal protein L28 | -0.010136 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0100858 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.00998434 |
| NRP1 | neuropilin 1 | -0.00996301 |
