| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.223898 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.17651 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.152724 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.145697 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.112596 |
| HDAC9 | histone deacetylase 9 | 0.101302 |
| JMJD1C | jumonji domain containing 1C | 0.0927801 |
| STC1 | stanniocalcin 1 | 0.086319 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0759481 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0744158 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0729005 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0699572 |
| CANX | calnexin | 0.0683964 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0620679 |
| SET | SET nuclear proto-oncogene | 0.0618497 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0611006 |
| LAMB3 | laminin, beta 3 | 0.0596126 |
| NUP58 | nucleoporin 58 | 0.0594723 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0541392 |
| NAV3 | neuron navigator 3 | 0.0540037 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.053048 |
| PTK2 | protein tyrosine kinase 2 | 0.0515096 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0491898 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.048693 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.048574 |
| VMP1 | vacuole membrane protein 1 | 0.0484964 |
| RPL7 | ribosomal protein L7 | 0.0484338 |
| CALU | calumenin | 0.0479771 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0460939 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0459726 |
| RBM39 | RNA binding motif protein 39 | 0.0452848 |
| KIF5B | kinesin family member 5B | 0.0446454 |
| TXNRD1 | thioredoxin reductase 1 | 0.0439066 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0435635 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0434957 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0432395 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0429567 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0421313 |
| FLNA | filamin A, alpha | 0.0416179 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.041584 |
| HLA-A | major histocompatibility complex, class I, A | 0.0414283 |
| GOLGA4 | golgin A4 | 0.0410796 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0409462 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0408047 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0402397 |
| SETX | senataxin | 0.0401516 |
| BRD2 | bromodomain containing 2 | 0.0401249 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0398902 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0398419 |
| RPL37A | ribosomal protein L37a | 0.0395528 |
| RPS6 | ribosomal protein S6 | 0.0391875 |
| MCL1 | myeloid cell leukemia 1 | 0.03905 |
| SETD5 | SET domain containing 5 | 0.0389656 |
| TPD52 | tumor protein D52 | 0.0389647 |
| NABP1 | nucleic acid binding protein 1 | 0.0378471 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0378196 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.037532 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0373933 |
| YTHDC1 | YTH domain containing 1 | 0.03695 |
| ARFGEF3 | ARFGEF family member 3 | 0.0369254 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.036917 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0367898 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0367402 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0365418 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0361797 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0360861 |
| PAPOLA | poly(A) polymerase alpha | 0.0346543 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0345017 |
| SON | SON DNA binding protein | 0.0344681 |
| TMF1 | TATA element modulatory factor 1 | 0.0344174 |
| RAB5A | RAB5A, member RAS oncogene family | 0.0341445 |
| SPAG9 | sperm associated antigen 9 | 0.0340474 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.034 |
| RBM25 | RNA binding motif protein 25 | 0.0338253 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0337265 |
| MTDH | metadherin | 0.0335136 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.033421 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0332157 |
| GOLGB1 | golgin B1 | 0.0329749 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.032609 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0323244 |
| SEC24A | SEC24 family member A | 0.0320334 |
| CRY1 | cryptochrome circadian clock 1 | 0.0320045 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0319193 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0317369 |
| PGK1 | phosphoglycerate kinase 1 | 0.0317149 |
| RUNX1 | runt-related transcription factor 1 | 0.0317097 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0316181 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0313393 |
| FRMD6 | FERM domain containing 6 | 0.0311766 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0310216 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0309186 |
| RAB7A | RAB7A, member RAS oncogene family | 0.03063 |
| BRD4 | bromodomain containing 4 | 0.0306105 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0305797 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0305207 |
| NCKAP1 | NCK-associated protein 1 | 0.0304601 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0303232 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0299695 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0298512 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.0783211 |
| FLNB | filamin B, beta | -0.0717058 |
| CALD1 | caldesmon 1 | -0.0695732 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0690638 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0667875 |
| RAD51B | RAD51 paralog B | -0.0612008 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0605568 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0589677 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0587508 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0508323 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0504926 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0501547 |
| FHIT | fragile histidine triad | -0.0497767 |
| NAV2 | neuron navigator 2 | -0.0433996 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0419735 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0417808 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0375427 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0372096 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.035836 |
| SMYD3 | SET and MYND domain containing 3 | -0.0350419 |
| RAB3IP | RAB3A interacting protein | -0.0349838 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.034237 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0339313 |
| RIGI | RNA sensor RIG-I | -0.033493 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0321886 |
| TMSB10 | thymosin beta 10 | -0.0312446 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0304422 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.030332 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.030154 |
| ANTXR2 | anthrax toxin receptor 2 | -0.029 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0288578 |
| RPLP0 | ribosomal protein, large, P0 | -0.0288284 |
| FHL2 | four and a half LIM domains 2 | -0.0284769 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0272432 |
| BNC2 | basonuclin 2 | -0.0270581 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0267473 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0254987 |
| DIAPH2 | diaphanous-related formin 2 | -0.0254369 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0253866 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0253321 |
| RPS24 | ribosomal protein S24 | -0.0248938 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0244479 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0237436 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0236375 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0234051 |
| AOPEP | aminopeptidase O (putative) | -0.0233853 |
| ANK2 | ankyrin 2, neuronal | -0.0229925 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0226823 |
| PKP4 | plakophilin 4 | -0.0225397 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0217431 |
| FOXO3 | forkhead box O3 | -0.0214153 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0210514 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0210302 |
| RPL26 | ribosomal protein L26 | -0.0209871 |
| RPL28 | ribosomal protein L28 | -0.0209733 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0208444 |
| ARSJ | arylsulfatase family, member J | -0.0208096 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0207324 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0205746 |
| CRACD | capping protein inhibiting regulator of actin dynamics | -0.0200823 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0200794 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0200462 |
| RNF169 | ring finger protein 169 | -0.0198544 |
| CCDC91 | coiled-coil domain containing 91 | -0.0197534 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0195765 |
| RPL35A | ribosomal protein L35a | -0.0195544 |
| VCL | vinculin | -0.0194407 |
| XPO6 | exportin 6 | -0.0190911 |
| ZHX3 | zinc fingers and homeoboxes 3 | -0.0189706 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0189412 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0187116 |
| CDCP1 | CUB domain containing protein 1 | -0.0185613 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0180723 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0179283 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0178731 |
| ZNF438 | zinc finger protein 438 | -0.0178543 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0177976 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0176072 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0174833 |
| CUL1 | cullin 1 | -0.0174762 |
| WWOX | WW domain containing oxidoreductase | -0.0172619 |
| CPNE3 | copine III | -0.0172506 |
| FRMD4A | FERM domain containing 4A | -0.0171234 |
| WASHC4 | WASH complex subunit 4 | -0.0168677 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0167598 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0164746 |
| CADM1 | cell adhesion molecule 1 | -0.0164331 |
| DST | dystonin | -0.0163947 |
| TTR | transthyretin | -0.0163207 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.016226 |
| NDRG1 | N-myc downstream regulated 1 | -0.0161635 |
| MSI2 | musashi RNA-binding protein 2 | -0.0161523 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0161109 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0160382 |
| MAPK1 | mitogen-activated protein kinase 1 | -0.0159265 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0158106 |
| RPLP2 | ribosomal protein, large, P2 | -0.0157729 |
| CREB1 | cAMP responsive element binding protein 1 | -0.0154206 |
| KIF13A | kinesin family member 13A | -0.0151762 |
| FOXP1 | forkhead box P1 | -0.0151175 |
