| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.149099 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0765286 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0743562 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0641681 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.061868 |
| GOLGA4 | golgin A4 | 0.0556818 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0532752 |
| POTEF | POTE ankyrin domain family, member F | 0.0443877 |
| VEGFA | vascular endothelial growth factor A | 0.0422124 |
| TGM2 | transglutaminase 2 | 0.0399148 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0397331 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0388882 |
| ZNF292 | zinc finger protein 292 | 0.0377863 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0374875 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0368787 |
| CENPF | centromere protein F, 350/400kDa | 0.0362413 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0341603 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0336625 |
| MSN | moesin | 0.0318575 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0317518 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0309415 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0306646 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0290574 |
| COPA | coatomer protein complex, subunit alpha | 0.027804 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0272899 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0269282 |
| PLEC | plectin | 0.0268385 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0263287 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.026158 |
| TPX2 | TPX2, microtubule-associated | 0.0245904 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0242825 |
| CCNL1 | cyclin L1 | 0.0242239 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0241469 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0240113 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0237014 |
| FLNA | filamin A, alpha | 0.0234334 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0234172 |
| CALU | calumenin | 0.0232797 |
| QKI | QKI, KH domain containing, RNA binding | 0.0232075 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0231632 |
| SPAG9 | sperm associated antigen 9 | 0.0231028 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0231 |
| NUP58 | nucleoporin 58 | 0.022858 |
| TMEM39A | transmembrane protein 39A | 0.02272 |
| NOP58 | NOP58 ribonucleoprotein | 0.0221318 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0220744 |
| THBS1 | thrombospondin 1 | 0.0218466 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0215961 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0215729 |
| WDR43 | WD repeat domain 43 | 0.0214665 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0214119 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0213346 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0212061 |
| SETD5 | SET domain containing 5 | 0.0210417 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0210089 |
| YBX1 | Y box binding protein 1 | 0.0208896 |
| TMF1 | TATA element modulatory factor 1 | 0.0205388 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0195995 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0194352 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0193332 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0193255 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0191649 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0190362 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0189584 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0185074 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0184987 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.018428 |
| HMGB2 | high mobility group box 2 | 0.0181656 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0179623 |
| RNF145 | ring finger protein 145 | 0.0176284 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | 0.0175412 |
| HDLBP | high density lipoprotein binding protein | 0.0175094 |
| TFG | TRK-fused gene | 0.0174844 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0174685 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.017439 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0174142 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0171821 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0171117 |
| MATR3 | matrin 3 | 0.0170741 |
| TPM3 | tropomyosin 3 | 0.0170122 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0170095 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0169819 |
| CANX | calnexin | 0.0169793 |
| ARF4 | ADP-ribosylation factor 4 | 0.016938 |
| SUCO | SUN domain containing ossification factor | 0.0167237 |
| HELZ | helicase with zinc finger | 0.0167125 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0166222 |
| SRP54 | signal recognition particle 54kDa | 0.0165444 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.016523 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0164822 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0164029 |
| RBM39 | RNA binding motif protein 39 | 0.0163631 |
| NCKAP1 | NCK-associated protein 1 | 0.0163309 |
| RLF | rearranged L-myc fusion | 0.0162942 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0162015 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0161078 |
| VMP1 | vacuole membrane protein 1 | 0.0160945 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0159909 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0159298 |
| OPTN | optineurin | 0.0158963 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.128102 |
| VIM | vimentin | -0.0829423 |
| MT2A | metallothionein 2A | -0.0790366 |
| COL1A1 | collagen, type I, alpha 1 | -0.0752726 |
| HLA-B | major histocompatibility complex, class I, B | -0.0741916 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.067608 |
| TMSB10 | thymosin beta 10 | -0.0651654 |
| COL1A2 | collagen, type I, alpha 2 | -0.0623843 |
| FRMD4A | FERM domain containing 4A | -0.0603385 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0547936 |
| B2M | beta-2-microglobulin | -0.0498481 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.045413 |
| FTL | ferritin, light polypeptide | -0.0452631 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0434531 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.040338 |
| FAM20C | family with sequence similarity 20, member C | -0.0385371 |
| RPLP1 | ribosomal protein, large, P1 | -0.0381862 |
| CDH13 | cadherin 13 | -0.0355912 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0344363 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0335785 |
| SP100 | SP100 nuclear antigen | -0.0321055 |
| TMEM178B | transmembrane protein 178B | -0.0316546 |
| LOXL2 | lysyl oxidase-like 2 | -0.0315563 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0307745 |
| RPL35A | ribosomal protein L35a | -0.0304083 |
| NAV1 | neuron navigator 1 | -0.0304027 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0296935 |
| NRP1 | neuropilin 1 | -0.029641 |
| ENO1 | enolase 1, (alpha) | -0.0282931 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0278455 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0268662 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0264747 |
| S100A6 | S100 calcium binding protein A6 | -0.0255532 |
| MTSS1 | metastasis suppressor 1 | -0.0248133 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0244163 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0239262 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0238451 |
| CAVIN1 | caveolae associated protein 1 | -0.021956 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0208126 |
| HLA-A | major histocompatibility complex, class I, A | -0.0206331 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0203755 |
| PCBP3 | poly(rC) binding protein 3 | -0.0203527 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0199464 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0197417 |
| HLA-C | major histocompatibility complex, class I, C | -0.0195711 |
| IER3 | immediate early response 3 | -0.0195504 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0195023 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0194152 |
| RPS21 | ribosomal protein S21 | -0.0193917 |
| HPCAL1 | hippocalcin-like 1 | -0.0189029 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0187621 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0186124 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0184901 |
| RNF213 | ring finger protein 213 | -0.0182846 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0182684 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0182444 |
| MEF2A | myocyte enhancer factor 2A | -0.0182415 |
| XAF1 | XIAP associated factor 1 | -0.0179259 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0179122 |
| SSH1 | slingshot protein phosphatase 1 | -0.0178773 |
| RPL34 | ribosomal protein L34 | -0.0177443 |
| RPS19 | ribosomal protein S19 | -0.0173716 |
| FHIT | fragile histidine triad | -0.0171661 |
| ACTG1 | actin gamma 1 | -0.0171286 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0170769 |
| RRBP1 | ribosome binding protein 1 | -0.0170743 |
| PMP22 | peripheral myelin protein 22 | -0.0169646 |
| RPL28 | ribosomal protein L28 | -0.0169469 |
| S100A10 | S100 calcium binding protein A10 | -0.0167562 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0166958 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0165795 |
| SEC61G | Sec61 gamma subunit | -0.0165758 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0164588 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0163849 |
| RPLP2 | ribosomal protein, large, P2 | -0.0163793 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0161041 |
| IL1B | interleukin 1, beta | -0.0160995 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0160794 |
| TPM1 | tropomyosin 1 (alpha) | -0.0160593 |
| RPL37A | ribosomal protein L37a | -0.0160211 |
| OXR1 | oxidation resistance 1 | -0.0159833 |
| VCL | vinculin | -0.0159311 |
| GLIS3 | GLIS family zinc finger 3 | -0.0158914 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0158503 |
| OSMR | oncostatin M receptor | -0.015783 |
| GNAS | GNAS complex locus | -0.0155395 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0152208 |
| RIGI | RNA sensor RIG-I | -0.0151966 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0151727 |
| IFI44L | interferon-induced protein 44-like | -0.0150654 |
| EGFR | epidermal growth factor receptor | -0.0149927 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0149877 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0149859 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0149624 |
| S100A9 | S100 calcium binding protein A9 | -0.014784 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0146871 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0145498 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.014549 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0143314 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.014266 |
