| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VGF | VGF nerve growth factor inducible | 0.185713 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102566 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0992002 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0898605 |
| MATR3 | matrin 3 | 0.0885593 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0872728 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0706776 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0699452 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0647219 |
| CHGB | chromogranin B | 0.058005 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0579626 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0539501 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0528355 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0528214 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0486665 |
| MCL1 | myeloid cell leukemia 1 | 0.0485489 |
| PNN | pinin, desmosome associated protein | 0.0478616 |
| MAP1B | microtubule-associated protein 1B | 0.0448666 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0441562 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0439425 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0426061 |
| TPM3 | tropomyosin 3 | 0.0425729 |
| POTEF | POTE ankyrin domain family, member F | 0.0425323 |
| RNF213 | ring finger protein 213 | 0.0407244 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0402665 |
| CCNL1 | cyclin L1 | 0.0398606 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0383477 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0382082 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.038181 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.038018 |
| TXNRD1 | thioredoxin reductase 1 | 0.0380047 |
| JUN | jun proto-oncogene | 0.0377896 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0376294 |
| CALR | calreticulin | 0.0374241 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0369476 |
| KIF1A | kinesin family member 1A | 0.0366138 |
| SIK3 | SIK family kinase 3 | 0.0355792 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0348281 |
| RBM25 | RNA binding motif protein 25 | 0.0343376 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0337021 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0331794 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0331045 |
| SQSTM1 | sequestosome 1 | 0.0329285 |
| INHBA | inhibin, beta A | 0.0328616 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0326147 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0325407 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0320155 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 0.0319346 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0312202 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0311048 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0310388 |
| GPHN | gephyrin | 0.0310146 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0303323 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0302613 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0300673 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0300233 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0299013 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0296541 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0291784 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0291363 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0289137 |
| KIF5B | kinesin family member 5B | 0.0287751 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0285259 |
| ADAR | adenosine deaminase, RNA-specific | 0.0284038 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0282927 |
| DSTN | destrin (actin depolymerizing factor) | 0.0281824 |
| TPM4 | tropomyosin 4 | 0.0281524 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0280838 |
| CANX | calnexin | 0.0280019 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0279159 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0278403 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0278091 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0277734 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0277336 |
| LOC112694756 | uncharaterized LOC112694756 | 0.027707 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0275705 |
| USP36 | ubiquitin specific peptidase 36 | 0.0274614 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0274389 |
| TUSC3 | tumor suppressor candidate 3 | 0.0273675 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0272749 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0272593 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0272391 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0272121 |
| YBX1 | Y box binding protein 1 | 0.026852 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0268221 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0264988 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0262757 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0262507 |
| DHFR | dihydrofolate reductase | 0.0261313 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.026126 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0261142 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.02606 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0260139 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0259605 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0258937 |
| LMNA | lamin A/C | 0.0258739 |
| SFSWAP | splicing factor, suppressor of white-apricot family | 0.0258095 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0257501 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0257453 |
| MCM4 | minichromosome maintenance complex component 4 | 0.0257017 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.0927462 |
| CA8 | carbonic anhydrase VIII | -0.0873356 |
| TENM1 | teneurin transmembrane protein 1 | -0.0841735 |
| NCKAP5 | NCK-associated protein 5 | -0.0825635 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0770198 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0676751 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.064222 |
| FAM13A | family with sequence similarity 13, member A | -0.0569511 |
| CENPF | centromere protein F, 350/400kDa | -0.0562377 |
| GPC6 | glypican 6 | -0.0555867 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0552552 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0543301 |
| PDE10A | phosphodiesterase 10A | -0.053221 |
| ENO1 | enolase 1, (alpha) | -0.0524705 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.050409 |
| PCBP3 | poly(rC) binding protein 3 | -0.0498971 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0492949 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0492833 |
| RAD51B | RAD51 paralog B | -0.0474442 |
| WDR45B | WD repeat domain 45B | -0.0465255 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0464828 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0458742 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0455643 |
| ESRRG | estrogen-related receptor gamma | -0.0445556 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0426767 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0422081 |
| EFNA5 | ephrin-A5 | -0.0406817 |
| FHIT | fragile histidine triad | -0.0403576 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0397881 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0375145 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0374586 |
| DTNA | dystrobrevin, alpha | -0.0365835 |
| FAM162A | family with sequence similarity 162, member A | -0.0365448 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0358355 |
| RORA | RAR-related orphan receptor A | -0.0350214 |
| KIF26B | kinesin family member 26B | -0.0348968 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.033642 |
| FKBP9 | FK506 binding protein 9, 63 kDa | -0.0324788 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0321112 |
| FGF14 | fibroblast growth factor 14 | -0.0319566 |
| NLGN1 | neuroligin 1 | -0.0318715 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0307727 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0303627 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | -0.0298991 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0293391 |
| PGK1 | phosphoglycerate kinase 1 | -0.0291963 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0287259 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0283514 |
| RYBP | RING1 and YY1 binding protein | -0.0278346 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0274917 |
| FRY | furry homolog (Drosophila) | -0.0273993 |
| RPLP1 | ribosomal protein, large, P1 | -0.0272355 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0270114 |
| SOBP | sine oculis binding protein homolog (Drosophila) | -0.0267896 |
| RIT2 | Ras-like without CAAX 2 | -0.0263815 |
| ZNF395 | zinc finger protein 395 | -0.0263606 |
| TOX | thymocyte selection-associated high mobility group box | -0.025753 |
| NGLY1 | N-glycanase 1 | -0.0257073 |
| CADM1 | cell adhesion molecule 1 | -0.0254412 |
| CNKSR3 | CNKSR family member 3 | -0.0253775 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0250978 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0249405 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0249015 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0248558 |
| DENND1A | DENN/MADD domain containing 1A | -0.0248534 |
| SYT1 | synaptotagmin I | -0.024731 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0243398 |
| NFIA | nuclear factor I/A | -0.0239448 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0236999 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.023432 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0231571 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.023145 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0227812 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0220254 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0219969 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0218791 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0218419 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0216404 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0216155 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0213648 |
| PHF21A | PHD finger protein 21A | -0.0210039 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0206273 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0205747 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0198987 |
| RPS16 | ribosomal protein S16 | -0.0197003 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0196797 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0196314 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0194501 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0193845 |
| JAM3 | junctional adhesion molecule 3 | -0.0193517 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | -0.0190686 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0190104 |
| RREB1 | ras responsive element binding protein 1 | -0.0189369 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0186525 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0186196 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0184863 |
| INVS | inversin | -0.0184428 |
| KBTBD2 | kelch repeat and BTB (POZ) domain containing 2 | -0.0183421 |
| PKIB | protein kinase (cAMP-dependent, catalytic) inhibitor beta | -0.0182807 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0182698 |
