| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.194862 |
| VIM | vimentin | 0.121668 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.118179 |
| FN1 | fibronectin 1 | 0.105947 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.100488 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0926635 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0889398 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0787954 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0769037 |
| SFTPA2 | surfactant protein A2 | 0.0748778 |
| FMN1 | formin 1 | 0.0745811 |
| GOLGA4 | golgin A4 | 0.074288 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0638158 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0625393 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0609864 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0580142 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0573691 |
| POTEF | POTE ankyrin domain family, member F | 0.0542517 |
| MATR3 | matrin 3 | 0.052865 |
| PGK1 | phosphoglycerate kinase 1 | 0.0518408 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0515301 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.051169 |
| MSN | moesin | 0.0510066 |
| SQSTM1 | sequestosome 1 | 0.0496363 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0479959 |
| SPAG9 | sperm associated antigen 9 | 0.0475232 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0469416 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0465037 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0455163 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0446026 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0441149 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0436715 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0419679 |
| LSAMP | limbic system-associated membrane protein | 0.0416947 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0399701 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0396409 |
| CLINT1 | clathrin interactor 1 | 0.039112 |
| TXNRD1 | thioredoxin reductase 1 | 0.0388028 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0384732 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0384186 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0383357 |
| RNF145 | ring finger protein 145 | 0.0381327 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0369787 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0362395 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0353716 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0352187 |
| MT2A | metallothionein 2A | 0.0349428 |
| SEC24A | SEC24 family member A | 0.0345918 |
| CD44 | CD44 molecule (Indian blood group) | 0.0344487 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0344387 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0342962 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0337142 |
| ATP13A3 | ATPase type 13A3 | 0.0333601 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0326642 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0325948 |
| RBM39 | RNA binding motif protein 39 | 0.0323089 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0318521 |
| CALU | calumenin | 0.0317058 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0315889 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.031573 |
| ANXA2 | annexin A2 | 0.031468 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0314494 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0313607 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0313501 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0311905 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0311192 |
| RPS6 | ribosomal protein S6 | 0.0311068 |
| PLEC | plectin | 0.031042 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0309394 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0309173 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0308937 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0307111 |
| EMP1 | epithelial membrane protein 1 | 0.0304545 |
| CCND1 | cyclin D1 | 0.0300108 |
| TKT | transketolase | 0.0299035 |
| VEGFA | vascular endothelial growth factor A | 0.0297708 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0297633 |
| TPM3 | tropomyosin 3 | 0.0296218 |
| KIF5B | kinesin family member 5B | 0.029509 |
| QKI | QKI, KH domain containing, RNA binding | 0.0292606 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0290053 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0284686 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0283775 |
| TNNC1 | troponin C type 1 (slow) | 0.0282864 |
| PTMA | prothymosin, alpha | 0.0279827 |
| PCBP2 | poly(rC) binding protein 2 | 0.0277037 |
| HSPA4 | heat shock 70kDa protein 4 | 0.027585 |
| NAV2 | neuron navigator 2 | 0.0274617 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0273125 |
| SEPTIN7 | septin 7 | 0.0270059 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0269803 |
| GOLGB1 | golgin B1 | 0.0269373 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0268898 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.026857 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0267764 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.026737 |
| WDR43 | WD repeat domain 43 | 0.0266053 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0264261 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0261855 |
| SEPTIN9 | septin 9 | 0.0261321 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.103594 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0522802 |
| FMNL2 | formin-like 2 | -0.0384828 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0372908 |
| RAD51B | RAD51 paralog B | -0.0368689 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0257958 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0256483 |
| FHIT | fragile histidine triad | -0.0255311 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0233647 |
| ITGB5 | integrin, beta 5 | -0.0233605 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0232212 |
| WWOX | WW domain containing oxidoreductase | -0.0231915 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0228337 |
| FLNB | filamin B, beta | -0.0221201 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0214928 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.0212019 |
| PCNX1 | pecanex 1 | -0.0208877 |
| CADM1 | cell adhesion molecule 1 | -0.0201288 |
| TCF20 | transcription factor 20 (AR1) | -0.0198653 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0195181 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0191648 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0187152 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0183868 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0182766 |
| CCDC91 | coiled-coil domain containing 91 | -0.0180938 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.018027 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.0178364 |
| PRELID2 | PRELI domain containing 2 | -0.017805 |
| TMEM45A | transmembrane protein 45A | -0.0175056 |
| DENND1A | DENN/MADD domain containing 1A | -0.0174458 |
| WDR26 | WD repeat domain 26 | -0.0169425 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0169203 |
| ZNF33A | zinc finger protein 33A | -0.0166362 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0163912 |
| FRMD3 | FERM domain containing 3 | -0.0159957 |
| RPL38 | ribosomal protein L38 | -0.0159885 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0158189 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0157816 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0156456 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0155436 |
| CDC27 | cell division cycle 27 | -0.0154795 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0154156 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0153205 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0152905 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0148334 |
| COX7B2 | cytochrome c oxidase subunit VIIb2 | -0.0147291 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.0146329 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | -0.0143335 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0142821 |
| RPLP1 | ribosomal protein, large, P1 | -0.0140868 |
| CLEC2D | C-type lectin domain family 2, member D | -0.014055 |
| TP63 | tumor protein p63 | -0.0140242 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0139441 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0138085 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0136422 |
| PCBP3 | poly(rC) binding protein 3 | -0.0135014 |
| CD58 | CD58 molecule | -0.0134734 |
| CDK6 | cyclin-dependent kinase 6 | -0.0134444 |
| RRM2 | ribonucleotide reductase M2 | -0.0132615 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0132452 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.0131442 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.013118 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.013043 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0128745 |
| EHBP1 | EH domain binding protein 1 | -0.012866 |
| NRG3 | neuregulin 3 | -0.0127825 |
| FNIP1 | folliculin interacting protein 1 | -0.0127548 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0127279 |
| NHSL1 | NHS-like 1 | -0.0127036 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0126059 |
| TMSB10 | thymosin beta 10 | -0.0125311 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0122199 |
| OGA | O-GlcNAcase | -0.0121612 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0121335 |
| MACROD2 | MACRO domain containing 2 | -0.0121188 |
| SSH2 | slingshot protein phosphatase 2 | -0.0120589 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0120141 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0120129 |
| RPS16 | ribosomal protein S16 | -0.0119863 |
| CCDC14 | coiled-coil domain containing 14 | -0.0119859 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0119739 |
| EFL1 | elongation factor like GTPase 1 | -0.0119342 |
| FRMD5 | FERM domain containing 5 | -0.011888 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | -0.0118688 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0118238 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0117794 |
| CUX1 | cut-like homeobox 1 | -0.0117231 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0116969 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0116505 |
| TRIP4 | thyroid hormone receptor interactor 4 | -0.0115778 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0114899 |
| COMMD10 | COMM domain containing 10 | -0.0114834 |
| PER3 | period circadian clock 3 | -0.0113826 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0113245 |
| KIAA1958 | KIAA1958 | -0.0112834 |
| NGLY1 | N-glycanase 1 | -0.011274 |
| PMP22 | peripheral myelin protein 22 | -0.0112172 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -0.011199 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0111842 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | -0.0111011 |
