| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.171526 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.115781 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.105862 |
| TMSB4X | thymosin beta 4, X-linked | 0.0938925 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0935453 |
| AHNAK | AHNAK nucleoprotein | 0.0913537 |
| EZR | ezrin | 0.0741601 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0717431 |
| CENPF | centromere protein F, 350/400kDa | 0.0703905 |
| ANXA1 | annexin A1 | 0.0685991 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0620258 |
| MKI67 | marker of proliferation Ki-67 | 0.0580511 |
| BMP10 | bone morphogenetic protein 10 | 0.0547229 |
| MATR3 | matrin 3 | 0.0540814 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0534747 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0515165 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0508999 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0508946 |
| SQSTM1 | sequestosome 1 | 0.0508395 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0489233 |
| CCNL1 | cyclin L1 | 0.0474432 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0473011 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0464021 |
| HMGB2 | high mobility group box 2 | 0.0457713 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0454208 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0442873 |
| DIAPH3 | diaphanous-related formin 3 | 0.0440931 |
| HJURP | Holliday junction recognition protein | 0.0440893 |
| POTEF | POTE ankyrin domain family, member F | 0.0433779 |
| ECT2 | epithelial cell transforming 2 | 0.0419907 |
| APP | amyloid beta (A4) precursor protein | 0.0415595 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0413068 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0408919 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0406458 |
| KIF5B | kinesin family member 5B | 0.0404188 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0403329 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0398693 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.03961 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0395695 |
| B2M | beta-2-microglobulin | 0.0390011 |
| ASPH | aspartate beta-hydroxylase | 0.0386927 |
| NAV2 | neuron navigator 2 | 0.0386019 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0374266 |
| BRD2 | bromodomain containing 2 | 0.0373925 |
| TAOK1 | TAO kinase 1 | 0.037132 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0365334 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0356655 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0354724 |
| RLF | rearranged L-myc fusion | 0.0351022 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.033904 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0336686 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0335718 |
| CALU | calumenin | 0.0335309 |
| SLMAP | sarcolemma associated protein | 0.0333857 |
| TPM4 | tropomyosin 4 | 0.0324842 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0322705 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0321382 |
| PLK2 | polo-like kinase 2 | 0.0316748 |
| PGK1 | phosphoglycerate kinase 1 | 0.0315738 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0313902 |
| ENO1 | enolase 1, (alpha) | 0.0312176 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0312069 |
| TPX2 | TPX2, microtubule-associated | 0.0309592 |
| CRY1 | cryptochrome circadian clock 1 | 0.0306901 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0305382 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0303828 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0301391 |
| XPO1 | exportin 1 | 0.029989 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0299521 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0295421 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0293975 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0290315 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0288663 |
| RHEB | Ras homolog enriched in brain | 0.0288463 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0284918 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0283842 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0282257 |
| TMF1 | TATA element modulatory factor 1 | 0.0281427 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0279633 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0279559 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0278504 |
| RBM25 | RNA binding motif protein 25 | 0.0277114 |
| SFTPA2 | surfactant protein A2 | 0.027401 |
| YBX1 | Y box binding protein 1 | 0.0273936 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0272285 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0269493 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.026639 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0265988 |
| TFG | TRK-fused gene | 0.0263933 |
| PTK2 | protein tyrosine kinase 2 | 0.0262022 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0259842 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0259718 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0258553 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0257971 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0254599 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0252408 |
| SEPTIN7 | septin 7 | 0.0252121 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0251801 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0251622 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0250503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.137867 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0591424 |
| S100A6 | S100 calcium binding protein A6 | -0.0560283 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0541458 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0431144 |
| FOXP1 | forkhead box P1 | -0.0427311 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0422067 |
| FLNB | filamin B, beta | -0.0420517 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0416476 |
| HDAC9 | histone deacetylase 9 | -0.0414096 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0391462 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0378637 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0371631 |
| USP3 | ubiquitin specific peptidase 3 | -0.0346348 |
| TMEM65 | transmembrane protein 65 | -0.0325324 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0300418 |
| EGFR | epidermal growth factor receptor | -0.02957 |
| EVI5 | ecotropic viral integration site 5 | -0.0288119 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.028428 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0259215 |
| ATOSA | atos homolog A | -0.025697 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0242211 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0239341 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.023532 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0233174 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0232652 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0226781 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0225221 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0220026 |
| ACTG1 | actin gamma 1 | -0.0215937 |
| MSI2 | musashi RNA-binding protein 2 | -0.0215548 |
| CYTH3 | cytohesin 3 | -0.0207885 |
| TCF12 | transcription factor 12 | -0.0205646 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0204715 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0204659 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0202143 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0200472 |
| PLXNA1 | plexin A1 | -0.0200219 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0199747 |
| AP2A2 | adaptor-related protein complex 2, alpha 2 subunit | -0.0191471 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0191363 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0189511 |
| ATP9B | ATPase, class II, type 9B | -0.0185135 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0184728 |
| RPL28 | ribosomal protein L28 | -0.0183881 |
| RPL35A | ribosomal protein L35a | -0.0182247 |
| RPLP1 | ribosomal protein, large, P1 | -0.0182149 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0181703 |
| CALR | calreticulin | -0.0180614 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0179201 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0178037 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0177997 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0177056 |
| ABHD12 | abhydrolase domain containing 12 | -0.0176341 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0176219 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0175228 |
| SGMS1 | sphingomyelin synthase 1 | -0.017518 |
| ANK2 | ankyrin 2, neuronal | -0.0168046 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0166695 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0166203 |
| WDR45B | WD repeat domain 45B | -0.0165682 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0164361 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | -0.0164288 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0163555 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0160623 |
| MRPL1 | mitochondrial ribosomal protein L1 | -0.015909 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0157968 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0157572 |
| RPS25 | ribosomal protein S25 | -0.0156832 |
| NF1 | neurofibromin 1 | -0.0156698 |
| NCOA3 | nuclear receptor coactivator 3 | -0.015544 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0154859 |
| TMEM165 | transmembrane protein 165 | -0.0153123 |
| RPL13A | ribosomal protein L13a | -0.015303 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0151549 |
| PRDM16 | PR domain containing 16 | -0.0151222 |
| RTN4 | reticulon 4 | -0.0150058 |
| RPS2 | ribosomal protein S2 | -0.0149446 |
| MEIS2 | Meis homeobox 2 | -0.0145828 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0144976 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0142194 |
| PHF21A | PHD finger protein 21A | -0.0141729 |
| WDFY3 | WD repeat and FYVE domain containing 3 | -0.0139432 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0139166 |
| PLCE1 | phospholipase C, epsilon 1 | -0.0138183 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0137492 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0136102 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0135787 |
| TMEM41B | transmembrane protein 41B | -0.0134847 |
| PCGF5 | polycomb group ring finger 5 | -0.0134628 |
| NCK1 | NCK adaptor protein 1 | -0.0134096 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.01337 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0133678 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0133025 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.0132762 |
| UBE4B | ubiquitination factor E4B | -0.0132175 |
| LOXL3 | lysyl oxidase-like 3 | -0.013109 |
| RPS16 | ribosomal protein S16 | -0.0130914 |
| LMBRD1 | LMBR1 domain containing 1 | -0.0130777 |
| DAPK1 | death-associated protein kinase 1 | -0.0130708 |
