Tirabrutinib (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.183642
SOD2 superoxide dismutase 2, mitochondrial 0.168293
EEF2 eukaryotic translation elongation factor 2 0.163078
FN1 fibronectin 1 0.125345
VIM vimentin 0.123066
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105747
HLA-B major histocompatibility complex, class I, B 0.100767
MYH9 myosin, heavy chain 9, non-muscle 0.0900356
SFTPA2 surfactant protein A2 0.0875241
ADM adrenomedullin 0.0863133
RPS4X ribosomal protein S4, X-linked 0.0769481
IGFBP3 insulin-like growth factor binding protein 3 0.0738378
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.071358
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0669379
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0634401
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0628618
TPT1 tumor protein, translationally-controlled 1 0.0585236
FTL ferritin, light polypeptide 0.0556293
CANX calnexin 0.0530426
UGCG UDP-glucose ceramide glucosyltransferase 0.0507091
PGK1 phosphoglycerate kinase 1 0.0505518
HLA-A major histocompatibility complex, class I, A 0.0488317
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0481214
CALR calreticulin 0.0478894
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0477189
IER3 immediate early response 3 0.0465159
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0449758
VEGFA vascular endothelial growth factor A 0.0425578
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0421725
HLA-E major histocompatibility complex, class I, E 0.0421377
FLNA filamin A, alpha 0.0420384
GOLGA4 golgin A4 0.0388078
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0357941
SQSTM1 sequestosome 1 0.0351387
PLIN2 perilipin 2 0.0347971
HILPDA hypoxia inducible lipid droplet-associated 0.0344565
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0343068
YBX1 Y box binding protein 1 0.0340981
KDM3A lysine (K)-specific demethylase 3A 0.0335153
ANXA2 annexin A2 0.033488
RND3 Rho family GTPase 3 0.0334323
TMSB4X thymosin beta 4, X-linked 0.033307
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0332704
TSC22D2 TSC22 domain family, member 2 0.0329797
BHLHE40 basic helix-loop-helix family, member e40 0.0329299
HELZ helicase with zinc finger 0.0323072
COL5A1 collagen, type V, alpha 1 0.031768
LOC112694756 uncharaterized LOC112694756 0.0316055
CDH13 cadherin 13 0.0313419
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0313039
OGA O-GlcNAcase 0.0309471
EIF1 eukaryotic translation initiation factor 1 0.030894
NAP1L1 nucleosome assembly protein 1-like 1 0.0307262
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0307203
MXI1 MAX interactor 1, dimerization protein 0.030561
ZFP36L1 ZFP36 ring finger protein-like 1 0.0296331
RAB7A RAB7A, member RAS oncogene family 0.0293225
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0292789
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285395
LDHA lactate dehydrogenase A 0.0280631
B2M beta-2-microglobulin 0.0279934
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0276008
DDIT4 DNA-damage-inducible transcript 4 0.0274642
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0270646
WDR45B WD repeat domain 45B 0.0267249
UBE2O ubiquitin-conjugating enzyme E2O 0.0264615
TMSB10 thymosin beta 10 0.0264271
RPL11 ribosomal protein L11 0.0261504
GNAS GNAS complex locus 0.0260864
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0257899
COL6A1 collagen, type VI, alpha 1 0.025745
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0255732
PTMA prothymosin, alpha 0.0249845
CADM1 cell adhesion molecule 1 0.0249806
RPL19 ribosomal protein L19 0.0247665
BTG1 B-cell translocation gene 1, anti-proliferative 0.0244267
NDRG1 N-myc downstream regulated 1 0.0240818
OPTN optineurin 0.0237887
ATP13A3 ATPase type 13A3 0.0233174
COL4A2 collagen, type IV, alpha 2 0.0231851
ANXA1 annexin A1 0.0227887
FMNL2 formin-like 2 0.0226943
QKI QKI, KH domain containing, RNA binding 0.0226941
SFRP1 secreted frizzled-related protein 1 0.0226876
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0222431
AHNAK AHNAK nucleoprotein 0.0218033
WDFY1 WD repeat and FYVE domain containing 1 0.0217799
FAM162A family with sequence similarity 162, member A 0.0215822
JUN jun proto-oncogene 0.0212383
TKT transketolase 0.0210225
RYBP RING1 and YY1 binding protein 0.0206143
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0205706
RAD23B RAD23 homolog B (S. cerevisiae) 0.0205588
CSDE1 cold shock domain containing E1, RNA-binding 0.0203982
INSIG1 insulin induced gene 1 0.020397
COL6A2 collagen, type VI, alpha 2 0.0203781
STC2 stanniocalcin 2 0.0203411
DDIT3 DNA-damage-inducible transcript 3 0.0202607
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0199094
HDLBP high density lipoprotein binding protein 0.0197334

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.197479
NAMPT nicotinamide phosphoribosyltransferase -0.120819
BICC1 BicC family RNA binding protein 1 -0.0701996
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0680262
FRMD4A FERM domain containing 4A -0.0646243
VCL vinculin -0.0605623
FNDC3B fibronectin type III domain containing 3B -0.0544717
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0511946
CD44 CD44 molecule (Indian blood group) -0.0489307
SMAD3 SMAD family member 3 -0.048511
KYNU kynureninase -0.0465241
EXT1 exostosin glycosyltransferase 1 -0.0444985
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.043438
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0420291
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0386394
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0379749
GLIS3 GLIS family zinc finger 3 -0.0375493
NAV2 neuron navigator 2 -0.0372211
ELL2 elongation factor, RNA polymerase II, 2 -0.0369406
RTN4 reticulon 4 -0.0365475
MKI67 marker of proliferation Ki-67 -0.0365381
CDCP1 CUB domain containing protein 1 -0.0359084
MSN moesin -0.0357914
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 -0.0341632
ZBTB38 zinc finger and BTB domain containing 38 -0.0329007
DUSP5 dual specificity phosphatase 5 -0.0312911
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0307182
RIGI RNA sensor RIG-I -0.0294348
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0287495
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0286829
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0282659
NAV1 neuron navigator 1 -0.0279849
OSMR oncostatin M receptor -0.0278706
MX1 MX dynamin-like GTPase 1 -0.027314
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.027214
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0267353
ZNFX1 zinc finger, NFX1-type containing 1 -0.0256559
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0255965
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0253093
TENT5A terminal nucleotidyltransferase 5A -0.0251913
BCAR3 breast cancer anti-estrogen resistance 3 -0.0250587
CENPF centromere protein F, 350/400kDa -0.0248567
PLSCR1 phospholipid scramblase 1 -0.0244588
FRMD5 FERM domain containing 5 -0.0244291
HDAC9 histone deacetylase 9 -0.0243217
SMYD3 SET and MYND domain containing 3 -0.0235587
TNS3 tensin 3 -0.0232789
RPS2 ribosomal protein S2 -0.0223201
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0218871
SYAP1 synapse associated protein 1 -0.021834
JMJD1C jumonji domain containing 1C -0.0210886
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0210564
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0208123
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0204756
GPC6 glypican 6 -0.0204489
TRIO trio Rho guanine nucleotide exchange factor -0.0200964
ZBTB20 zinc finger and BTB domain containing 20 -0.0200166
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0199778
NABP1 nucleic acid binding protein 1 -0.0197141
NT5E 5'-nucleotidase, ecto (CD73) -0.019521
PCLO piccolo presynaptic cytomatrix protein -0.0193496
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0192511
FER fer (fps/fes related) tyrosine kinase -0.019169
ATXN1 ataxin 1 -0.0189671
TNIP1 TNFAIP3 interacting protein 1 -0.0189612
RAD51B RAD51 paralog B -0.0188945
SBF2 SET binding factor 2 -0.0188496
VMP1 vacuole membrane protein 1 -0.0187351
NFE2L2 nuclear factor, erythroid 2-like 2 -0.018674
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0185315
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0184749
HDAC8 histone deacetylase 8 -0.0184177
FMN1 formin 1 -0.0182775
SVIL supervillin -0.0181818
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0179371
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0178834
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0178502
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.01781
NRIP1 nuclear receptor interacting protein 1 -0.0176207
BIRC2 baculoviral IAP repeat containing 2 -0.0174972
AFDN afadin, adherens junction formation factor -0.017456
ATG10 autophagy related 10 -0.0172857
XRN1 5'-3' exoribonuclease 1 -0.0172355
STK17A serine/threonine kinase 17a -0.0170472
TGM2 transglutaminase 2 -0.0169815
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0167108
DST dystonin -0.0167017
PLPP3 phospholipid phosphatase 3 -0.0166965
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0166649
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0166135
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0164038
METTL15 methyltransferase like 15 -0.0163284
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0163229
SAMHD1 SAM domain and HD domain 1 -0.0162501
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0161854
CLIC4 chloride intracellular channel 4 -0.0161694
FAM3C family with sequence similarity 3, member C -0.0161579
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0160133
MYO9A myosin IXA -0.0158702
IGFBP7 insulin-like growth factor binding protein 7 -0.0157138