Tirabrutinib (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HLA-B major histocompatibility complex, class I, B 0.151044
B2M beta-2-microglobulin 0.130041
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.103158
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0956405
STC1 stanniocalcin 1 0.073036
TGFBI transforming growth factor, beta-induced, 68kDa 0.0709893
TMSB10 thymosin beta 10 0.0691865
TRA2A transformer 2 alpha homolog (Drosophila) 0.0636373
VIM vimentin 0.0553681
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0524184
SOD2 superoxide dismutase 2, mitochondrial 0.048792
MT2A metallothionein 2A 0.0485875
CALR calreticulin 0.0480353
SEC31A SEC31 homolog A (S. cerevisiae) 0.0472879
PTMA prothymosin, alpha 0.0472103
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0469909
COL6A1 collagen, type VI, alpha 1 0.0466377
FTH1 ferritin, heavy polypeptide 1 0.0464174
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0442682
IL6 interleukin 6 0.0423668
HLA-A major histocompatibility complex, class I, A 0.0410232
GOLGA4 golgin A4 0.0407589
TIMP3 TIMP metallopeptidase inhibitor 3 0.0399977
MATR3 matrin 3 0.0396998
CCNI cyclin I 0.0394199
IQGAP1 IQ motif containing GTPase activating protein 1 0.0389289
NAMPT nicotinamide phosphoribosyltransferase 0.0376845
HIP1 huntingtin interacting protein 1 0.0366529
HLA-C major histocompatibility complex, class I, C 0.0357468
CANX calnexin 0.0351649
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0345033
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0342888
H3-3B H3.3 histone B 0.0331981
RAB1A RAB1A, member RAS oncogene family 0.0329843
CALU calumenin 0.0326192
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0323856
BHLHE40 basic helix-loop-helix family, member e40 0.0323348
COPA coatomer protein complex, subunit alpha 0.032049
PDIA3 protein disulfide isomerase family A, member 3 0.0315578
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.031334
ZNF395 zinc finger protein 395 0.0306894
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0306299
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0299381
SKIC3 SKI3 subunit of superkiller complex 0.0298357
EIF1 eukaryotic translation initiation factor 1 0.02942
SDC4 syndecan 4 0.0282684
ADM adrenomedullin 0.027814
RND3 Rho family GTPase 3 0.0276337
WASF2 WAS protein family, member 2 0.0274358
ZNF292 zinc finger protein 292 0.0274308
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0271619
FMNL2 formin-like 2 0.0268009
RBM39 RNA binding motif protein 39 0.0265896
AHNAK AHNAK nucleoprotein 0.0260562
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0259428
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.025707
HOOK2 hook microtubule-tethering protein 2 0.0255217
ANKRD11 ankyrin repeat domain 11 0.0249682
GOLGB1 golgin B1 0.0246881
TM4SF1 transmembrane 4 L six family member 1 0.0244064
TENT2 terminal nucleotidyltransferase 2 0.0237893
SEPTIN7 septin 7 0.0236827
ANXA5 annexin A5 0.0236328
RBM25 RNA binding motif protein 25 0.023541
LGALS1 lectin, galactoside-binding, soluble, 1 0.0227066
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0225829
TMEM39A transmembrane protein 39A 0.0225185
ZCCHC7 zinc finger, CCHC domain containing 7 0.0223627
TMED9 transmembrane emp24 protein transport domain containing 9 0.0222726
ANXA1 annexin A1 0.0221439
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0220128
RPS23 ribosomal protein S23 0.0219931
CSDE1 cold shock domain containing E1, RNA-binding 0.0218773
LOC112694756 uncharaterized LOC112694756 0.0217692
MARCHF6 membrane associated ring-CH-type finger 6 0.0217394
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.021639
FTL ferritin, light polypeptide 0.0215719
AKAP13 A kinase (PRKA) anchor protein 13 0.0215564
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0215412
IGFBP7 insulin-like growth factor binding protein 7 0.0215071
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0214998
PTN pleiotrophin 0.0213482
TFG TRK-fused gene 0.0212451
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0212166
RPL11 ribosomal protein L11 0.0211505
FUS FUS RNA binding protein 0.0211481
FNDC3A fibronectin type III domain containing 3A 0.0211119
SRP54 signal recognition particle 54kDa 0.021083
PTGES2 prostaglandin E synthase 2 0.0210485
UGCG UDP-glucose ceramide glucosyltransferase 0.0210369
LIMS1 LIM and senescent cell antigen-like domains 1 0.0209908
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0209136
RNF24 ring finger protein 24 0.0208749
HMGB2 high mobility group box 2 0.0207349
AFF4 AF4/FMR2 family, member 4 0.0206931
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0204852
OPTN optineurin 0.0201354
TMEM165 transmembrane protein 165 0.0201325
UBC ubiquitin C 0.0199308
EEF2 eukaryotic translation elongation factor 2 0.0197665

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.0432427
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0391981
SMYD3 SET and MYND domain containing 3 -0.0385129
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0285338
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0280767
VCL vinculin -0.0270921
PSD3 pleckstrin and Sec7 domain containing 3 -0.0269933
ASPH aspartate beta-hydroxylase -0.0259648
EGFR epidermal growth factor receptor -0.0246206
SDK1 sidekick cell adhesion molecule 1 -0.0245356
COL7A1 collagen, type VII, alpha 1 -0.0240021
RAI1 retinoic acid induced 1 -0.0239061
ZBTB20 zinc finger and BTB domain containing 20 -0.0227604
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.022423
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.02123
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0199379
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0198093
C1D C1D nuclear receptor corepressor -0.0197118
DPYSL2 dihydropyrimidinase-like 2 -0.0195298
OGA O-GlcNAcase -0.0192315
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0189389
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0187558
PRKD1 protein kinase D1 -0.0185149
MRTFA myocardin related transcription factor A -0.0180023
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0168271
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0160473
ACTN1 actinin, alpha 1 -0.0159426
AFDN afadin, adherens junction formation factor -0.0155124
TGM2 transglutaminase 2 -0.0154196
KIAA1217 KIAA1217 -0.015414
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0152877
DLG1 discs, large homolog 1 (Drosophila) -0.0152097
LPP LIM domain containing preferred translocation partner in lipoma -0.0150955
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0148918
C1ORF21 chromosome 1 open reading frame 21 -0.0147534
C3 complement component 3 -0.0147359
FLNB filamin B, beta -0.0145426
RUNX1 runt-related transcription factor 1 -0.0144703
MACF1 microtubule-actin crosslinking factor 1 -0.0144364
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0144236
TSC22D2 TSC22 domain family, member 2 -0.0142087
FOXO3 forkhead box O3 -0.0141937
HIPK2 homeodomain interacting protein kinase 2 -0.0141834
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0141105
RGS17 regulator of G-protein signaling 17 -0.0139727
FRYL FRY-like -0.0139153
MEF2A myocyte enhancer factor 2A -0.0137955
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0137617
MRPS6 mitochondrial ribosomal protein S6 -0.0137498
PRELID2 PRELI domain containing 2 -0.0135718
KIF2A kinesin heavy chain member 2A -0.0135011
GRB10 growth factor receptor-bound protein 10 -0.0133841
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0133408
MYOF myoferlin -0.0132721
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0131789
LASP1 LIM and SH3 protein 1 -0.0131691
ECE1 endothelin converting enzyme 1 -0.0131008
PKP4 plakophilin 4 -0.0130787
COL6A3 collagen, type VI, alpha 3 -0.0129157
USP47 ubiquitin specific peptidase 47 -0.0128201
MED13L mediator complex subunit 13-like -0.012669
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0126402
PIAS2 protein inhibitor of activated STAT, 2 -0.0124033
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0123808
DGKG diacylglycerol kinase, gamma 90kDa -0.0123703
MTCL1 microtubule crosslinking factor 1 -0.0123525
JAZF1 JAZF zinc finger 1 -0.0123354
NHSL1 NHS-like 1 -0.0122622
HMGXB3 HMG box domain containing 3 -0.01225
FAM3C family with sequence similarity 3, member C -0.012237
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0121157
FNDC3B fibronectin type III domain containing 3B -0.0121052
CDK6 cyclin-dependent kinase 6 -0.0120768
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0119433
NAV1 neuron navigator 1 -0.0119327
PCNX4 pecanex 4 -0.0119091
CST3 cystatin C -0.011885
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0118722
OSMR oncostatin M receptor -0.0118613
TIMP1 TIMP metallopeptidase inhibitor 1 -0.011821
INHBA inhibin, beta A -0.0117796
SETBP1 SET binding protein 1 -0.011692
GSE1 Gse1 coiled-coil protein -0.0115208
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0115087
R3HCC1L R3H domain and coiled-coil containing 1-like -0.0114993
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -0.011433
CUL3 cullin 3 -0.0113915
WNK1 WNK lysine deficient protein kinase 1 -0.0113722
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0113661
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0112048
ARHGAP24 Rho GTPase activating protein 24 -0.011142
SOCS5 suppressor of cytokine signaling 5 -0.0110948
ZEB1 zinc finger E-box binding homeobox 1 -0.011085
CD47 CD47 molecule -0.011072
IWS1 IWS1 homolog (S. cerevisiae) -0.0110315
AFAP1 actin filament associated protein 1 -0.0109737
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0109547
NRIP1 nuclear receptor interacting protein 1 -0.0109288
TGFB1 transforming growth factor, beta 1 -0.0109259
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.010839