| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.141772 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.103353 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0908736 |
| LOC112694756 | uncharaterized LOC112694756 | 0.077474 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0593025 |
| ANXA2 | annexin A2 | 0.0534078 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0467323 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0442993 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0441294 |
| FLNB | filamin B, beta | 0.0422025 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0410594 |
| AHNAK | AHNAK nucleoprotein | 0.0391336 |
| CAPRIN2 | caprin family member 2 | 0.0371288 |
| MAP1B | microtubule-associated protein 1B | 0.035722 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0344932 |
| CEP250 | centrosomal protein 250kDa | 0.0335086 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0335027 |
| FLNA | filamin A, alpha | 0.0329389 |
| SFTPA2 | surfactant protein A2 | 0.0326293 |
| CANX | calnexin | 0.0319861 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0319225 |
| NDRG1 | N-myc downstream regulated 1 | 0.031589 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0287314 |
| SEC24A | SEC24 family member A | 0.0286792 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0285692 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0281919 |
| PKM | pyruvate kinase, muscle | 0.0281494 |
| INSIG1 | insulin induced gene 1 | 0.0280107 |
| IER3 | immediate early response 3 | 0.0280068 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0276528 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0275276 |
| HMGA2 | high mobility group AT-hook 2 | 0.0273738 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0267139 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.026667 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0265375 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0264621 |
| ITGB4 | integrin, beta 4 | 0.0263804 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0262005 |
| TPM4 | tropomyosin 4 | 0.026155 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0247455 |
| SNX3 | sorting nexin 3 | 0.0244934 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0244313 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0240296 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0239681 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0238167 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0237397 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0235372 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.023324 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0232157 |
| ADM | adrenomedullin | 0.0231466 |
| TMSB10 | thymosin beta 10 | 0.023108 |
| SCRN1 | secernin 1 | 0.0227171 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0224562 |
| DNER | delta/notch-like EGF repeat containing | 0.0219889 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.021536 |
| FAM13A | family with sequence similarity 13, member A | 0.0214814 |
| SEC13 | SEC13 homolog (S. cerevisiae) | 0.0214619 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0214296 |
| FSCN1 | fascin actin-bundling protein 1 | 0.0212516 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0209831 |
| RPS4X | ribosomal protein S4, X-linked | 0.0208448 |
| COPA | coatomer protein complex, subunit alpha | 0.0204872 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0202283 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0201382 |
| PYGL | phosphorylase, glycogen, liver | 0.0197842 |
| YBX1 | Y box binding protein 1 | 0.0197106 |
| HDLBP | high density lipoprotein binding protein | 0.0196209 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0194371 |
| CCDC47 | coiled-coil domain containing 47 | 0.0192614 |
| RPS6 | ribosomal protein S6 | 0.0191039 |
| NEK6 | NIMA-related kinase 6 | 0.018983 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0189705 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.018916 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0186624 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0185366 |
| CALR | calreticulin | 0.0185215 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0184868 |
| SH3GL1 | SH3-domain GRB2-like 1 | 0.018449 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0184272 |
| ARF4 | ADP-ribosylation factor 4 | 0.0184112 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0183974 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0183684 |
| AFDN | afadin, adherens junction formation factor | 0.0183348 |
| OPTN | optineurin | 0.0181795 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0181237 |
| CLIC4 | chloride intracellular channel 4 | 0.0179948 |
| SIK3 | SIK family kinase 3 | 0.0179831 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0179723 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0179531 |
| ANXA1 | annexin A1 | 0.0179352 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0178335 |
| INTS13 | integrator complex subunit 13 | 0.0178185 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0177596 |
| GPR107 | G protein-coupled receptor 107 | 0.0177456 |
| ACLY | ATP citrate lyase | 0.01764 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0176302 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0174779 |
| HBP1 | HMG-box transcription factor 1 | 0.0173268 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0171172 |
| POTEF | POTE ankyrin domain family, member F | 0.0169974 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMYD3 | SET and MYND domain containing 3 | -0.138618 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0945628 |
| RBM39 | RNA binding motif protein 39 | -0.0921336 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0865343 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0861902 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.075326 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0741594 |
| ATM | ATM serine/threonine kinase | -0.0736049 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0685307 |
| DST | dystonin | -0.0591275 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0558486 |
| PHF20 | PHD finger protein 20 | -0.0537068 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0535286 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0530318 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0523825 |
| GOLGA4 | golgin A4 | -0.0516111 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0513932 |
| TPX2 | TPX2, microtubule-associated | -0.0507509 |
| CENPF | centromere protein F, 350/400kDa | -0.0475989 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0474845 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0461338 |
| MRE11 | MRE11 homolog, double strand break repair nuclease | -0.0447652 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0441994 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0439652 |
| YAP1 | Yes-associated protein 1 | -0.0418198 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0417196 |
| USP34 | ubiquitin specific peptidase 34 | -0.0406074 |
| ERBIN | erbb2 interacting protein | -0.0405567 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0401453 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0400336 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0395333 |
| RIGI | RNA sensor RIG-I | -0.037894 |
| ANLN | anillin, actin binding protein | -0.0378073 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0356232 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0353915 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0352091 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.034759 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.034673 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0345149 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.0344599 |
| DENND4A | DENN/MADD domain containing 4A | -0.0340161 |
| CENPP | centromere protein P | -0.0340044 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0338933 |
| YBX3 | Y box binding protein 3 | -0.0337762 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0336098 |
| GPHN | gephyrin | -0.0334329 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0331578 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0329817 |
| CPNE1 | copine I | -0.0327955 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0324876 |
| MT2A | metallothionein 2A | -0.0323273 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0322976 |
| OGA | O-GlcNAcase | -0.0322345 |
| OSMR | oncostatin M receptor | -0.0321014 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0318744 |
| TXNRD1 | thioredoxin reductase 1 | -0.0308978 |
| CEP350 | centrosomal protein 350kDa | -0.0308362 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0304153 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0302171 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0297675 |
| RBMX | RNA binding motif protein, X-linked | -0.0297073 |
| RAD51B | RAD51 paralog B | -0.0294153 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0293696 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0293076 |
| CD44 | CD44 molecule (Indian blood group) | -0.0290788 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0289607 |
| RDX | radixin | -0.0285588 |
| CCNH | cyclin H | -0.0285068 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.028379 |
| TCERG1 | transcription elongation regulator 1 | -0.0283422 |
| PTMA | prothymosin, alpha | -0.0282564 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0282385 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0281895 |
| RPLP1 | ribosomal protein, large, P1 | -0.0280986 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0278796 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.027829 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0277984 |
| RPL36 | ribosomal protein L36 | -0.0277843 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0277796 |
| TFRC | transferrin receptor | -0.0276097 |
| ATG7 | autophagy related 7 | -0.0275439 |
| METTL15 | methyltransferase like 15 | -0.0273684 |
| DENND5B | DENN/MADD domain containing 5B | -0.0273548 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0271187 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0270095 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0269957 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0269246 |
| VMP1 | vacuole membrane protein 1 | -0.0267001 |
| TMEM123 | transmembrane protein 123 | -0.0265907 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0265092 |
| SPAG9 | sperm associated antigen 9 | -0.0259681 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0258201 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0257192 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0255786 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0255211 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0255163 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0252698 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0251407 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0250567 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0250076 |
