Tirabrutinib (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.122675
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0928426
CXCL8 chemokine (C-X-C motif) ligand 8 0.0649912
HILPDA hypoxia inducible lipid droplet-associated 0.0623528
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0606679
NDRG1 N-myc downstream regulated 1 0.0593032
RNF145 ring finger protein 145 0.058961
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0568196
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0545364
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0543994
SUCO SUN domain containing ossification factor 0.0507809
GOLGA4 golgin A4 0.0485267
FAM13A family with sequence similarity 13, member A 0.0484039
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0482478
VEGFA vascular endothelial growth factor A 0.0480862
LMNA lamin A/C 0.044099
NAMPT nicotinamide phosphoribosyltransferase 0.0432631
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0429897
HELZ helicase with zinc finger 0.0415633
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0415533
EEF2 eukaryotic translation elongation factor 2 0.0413312
SFTPA2 surfactant protein A2 0.0411686
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0396964
BHLHE40 basic helix-loop-helix family, member e40 0.0391766
NUP58 nucleoporin 58 0.03914
PRRC2C proline-rich coiled-coil 2C 0.0386967
COPA coatomer protein complex, subunit alpha 0.0386768
EMP1 epithelial membrane protein 1 0.0374608
RICTOR RPTOR independent companion of MTOR, complex 2 0.0374375
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0367316
UBA6 ubiquitin-like modifier activating enzyme 6 0.0362231
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0354166
SOD2 superoxide dismutase 2, mitochondrial 0.0348991
NOP58 NOP58 ribonucleoprotein 0.0343022
APLP2 amyloid beta (A4) precursor-like protein 2 0.0337796
CD109 CD109 molecule 0.0336024
EZR ezrin 0.0333484
OGA O-GlcNAcase 0.0323221
ZNF292 zinc finger protein 292 0.0323135
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0312958
YBX3 Y box binding protein 3 0.0298256
UGCG UDP-glucose ceramide glucosyltransferase 0.0297056
SPAG9 sperm associated antigen 9 0.0294131
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0293282
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0292783
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0287871
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0286079
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0283392
WDR45B WD repeat domain 45B 0.0280355
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.028021
TPD52 tumor protein D52 0.0278815
INSIG2 insulin induced gene 2 0.0275872
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0275518
BIRC3 baculoviral IAP repeat containing 3 0.0272315
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0268647
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0264778
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0264101
RBM39 RNA binding motif protein 39 0.0263152
EPS8 epidermal growth factor receptor pathway substrate 8 0.0263021
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0260945
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0260708
MYH9 myosin, heavy chain 9, non-muscle 0.026066
TPR translocated promoter region, nuclear basket protein 0.025838
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0251861
HDGF hepatoma-derived growth factor 0.0250304
CANX calnexin 0.024858
ACADVL acyl-CoA dehydrogenase, very long chain 0.0245455
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0244989
SRP54 signal recognition particle 54kDa 0.0239647
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0238986
SETD5 SET domain containing 5 0.0237652
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0235837
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0235117
PELI1 pellino E3 ubiquitin protein ligase 1 0.0234528
ZSWIM6 zinc finger, SWIM-type containing 6 0.0233191
KDM2A lysine (K)-specific demethylase 2A 0.0231352
CRY1 cryptochrome circadian clock 1 0.0230481
CALR calreticulin 0.0228259
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0227487
SEC23A Sec23 homolog A (S. cerevisiae) 0.0226519
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0226246
RBM25 RNA binding motif protein 25 0.0224326
ATF3 activating transcription factor 3 0.0224233
PDIA6 protein disulfide isomerase family A, member 6 0.0222738
HIPK1 homeodomain interacting protein kinase 1 0.0221989
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0221193
FXR1 fragile X mental retardation, autosomal homolog 1 0.0216327
NAP1L1 nucleosome assembly protein 1-like 1 0.0215398
QKI QKI, KH domain containing, RNA binding 0.0214551
DDIT4 DNA-damage-inducible transcript 4 0.0214399
ADAM17 ADAM metallopeptidase domain 17 0.0213953
KTN1 kinectin 1 (kinesin receptor) 0.0213839
RAB8B RAB8B, member RAS oncogene family 0.0212905
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.0210387
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0210045
ADAM9 ADAM metallopeptidase domain 9 0.0208649
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0207858
KMT2E lysine (K)-specific methyltransferase 2E 0.0206518
YBX1 Y box binding protein 1 0.0205584
SEC24A SEC24 family member A 0.0205289

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.26035
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.208957
HMGA2 high mobility group AT-hook 2 -0.187739
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.179326
FN1 fibronectin 1 -0.141355
ITGA1 integrin, alpha 1 -0.113572
GLIS3 GLIS family zinc finger 3 -0.0936465
EFNA5 ephrin-A5 -0.0813181
ASPH aspartate beta-hydroxylase -0.0802484
TMEM156 transmembrane protein 156 -0.0796781
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.07533
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0713328
HIPK2 homeodomain interacting protein kinase 2 -0.0653864
VCL vinculin -0.0638947
NRIP1 nuclear receptor interacting protein 1 -0.061702
EXT1 exostosin glycosyltransferase 1 -0.0615407
SYT1 synaptotagmin I -0.0614681
OSMR oncostatin M receptor -0.0593063
NRP1 neuropilin 1 -0.0527748
KLHL5 kelch-like family member 5 -0.0515767
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0451639
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0446742
SQSTM1 sequestosome 1 -0.0427606
IFI16 interferon, gamma-inducible protein 16 -0.0426782
RAI14 retinoic acid induced 14 -0.0418487
NTN4 netrin 4 -0.0413823
SOX4 SRY (sex determining region Y)-box 4 -0.0403198
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0398586
TAS2R14 taste receptor, type 2, member 14 -0.0392238
IFI27 interferon, alpha-inducible protein 27 -0.0391236
ETV1 ets variant 1 -0.0389508
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0372303
ZBTB20 zinc finger and BTB domain containing 20 -0.0372049
ETV6 ets variant 6 -0.0368729
LRMDA leucine rich melanocyte differentiation associated -0.0363773
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.034702
RUNX2 runt-related transcription factor 2 -0.0343784
TMSB10 thymosin beta 10 -0.0329502
NPAS2 neuronal PAS domain protein 2 -0.0329308
TSC22D1 TSC22 domain family, member 1 -0.0320638
FOXP1 forkhead box P1 -0.0311221
AEBP2 AE binding protein 2 -0.0309989
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0308645
AOPEP aminopeptidase O (putative) -0.0305155
MBD5 methyl-CpG binding domain protein 5 -0.0297544
HPCAL1 hippocalcin-like 1 -0.0294232
FAM20C family with sequence similarity 20, member C -0.0292301
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0289333
BICD1 bicaudal D homolog 1 (Drosophila) -0.0288519
ACTG1 actin gamma 1 -0.0288386
NPC1 Niemann-Pick disease, type C1 -0.0286632
RANBP17 RAN binding protein 17 -0.0275251
RNF213 ring finger protein 213 -0.0264207
TTC28 tetratricopeptide repeat domain 28 -0.0262794
SLC35F3 solute carrier family 35, member F3 -0.0256073
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0255003
DNAH5 dynein, axonemal, heavy chain 5 -0.0252275
PRH1 proline-rich protein HaeIII subfamily 1 -0.0240798
FTL ferritin, light polypeptide -0.0235
NBEA neurobeachin -0.0232896
MCTP2 multiple C2 domains, transmembrane 2 -0.0231299
RAD51B RAD51 paralog B -0.0228478
ITGB5 integrin, beta 5 -0.0227765
TOP1 topoisomerase (DNA) I -0.0227699
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0227645
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0226199
ADD3 adducin 3 (gamma) -0.0224033
BABAM2 BRISC and BRCA1 A complex member 2 -0.0220896
TNS3 tensin 3 -0.0215975
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0211619
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0211183
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0210549
IFI6 interferon, alpha-inducible protein 6 -0.0209753
NAV1 neuron navigator 1 -0.0209103
ZMYND8 zinc finger, MYND-type containing 8 -0.0208648
SEPTIN9 septin 9 -0.0206842
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0205531
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0205501
PALLD palladin, cytoskeletal associated protein -0.0205431
DNAH14 dynein, axonemal, heavy chain 14 -0.0203097
TSHZ2 teashirt zinc finger homeobox 2 -0.0201263
TPT1 tumor protein, translationally-controlled 1 -0.0200948
ARHGAP5 Rho GTPase activating protein 5 -0.0199855
PDE4D phosphodiesterase 4D, cAMP-specific -0.0199543
DPYD dihydropyrimidine dehydrogenase -0.0199399
TMEM165 transmembrane protein 165 -0.0198401
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0198312
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0197737
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0196119
MAML2 mastermind-like 2 (Drosophila) -0.0195848
SSH1 slingshot protein phosphatase 1 -0.0195499
S100A6 S100 calcium binding protein A6 -0.0193447
RAB31 RAB31, member RAS oncogene family -0.0191728
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0190946
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0190337
MX2 MX dynamin-like GTPase 2 -0.0189568
BPTF bromodomain PHD finger transcription factor -0.0188356
LAMA4 laminin, alpha 4 -0.0187658
GCC2 GRIP and coiled-coil domain containing 2 -0.0187153
PRKCA protein kinase C, alpha -0.0186215