| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.230988 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.161082 |
| KRT18 | keratin 18, type I | 0.152957 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0848004 |
| FTL | ferritin, light polypeptide | 0.0816364 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0761732 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.065835 |
| MATR3 | matrin 3 | 0.0634564 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0617282 |
| ANXA2 | annexin A2 | 0.0609581 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0608451 |
| GOLGA4 | golgin A4 | 0.0555514 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0552488 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0532688 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0509773 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0501212 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0485426 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0484528 |
| RBM39 | RNA binding motif protein 39 | 0.0482044 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0479541 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0474183 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0474135 |
| GNAS | GNAS complex locus | 0.0466426 |
| EPCAM | epithelial cell adhesion molecule | 0.045412 |
| TMSB4X | thymosin beta 4, X-linked | 0.0447683 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0440584 |
| CCND1 | cyclin D1 | 0.0436917 |
| H1-0 | H1.0 linker histone | 0.043446 |
| KRT8 | keratin 8, type II | 0.0432714 |
| HMGB2 | high mobility group box 2 | 0.0421899 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0413979 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0401609 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.039575 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0382513 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0378266 |
| ZNF292 | zinc finger protein 292 | 0.0375533 |
| SLC38A1 | solute carrier family 38, member 1 | 0.037383 |
| CANX | calnexin | 0.0372136 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0354804 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0350666 |
| RPS6 | ribosomal protein S6 | 0.0350337 |
| MTMR3 | myotubularin related protein 3 | 0.0345455 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0342078 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0338495 |
| USP3 | ubiquitin specific peptidase 3 | 0.033749 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0331742 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0320191 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0315643 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0304983 |
| UBC | ubiquitin C | 0.0294516 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0293457 |
| HBP1 | HMG-box transcription factor 1 | 0.0293146 |
| S100A6 | S100 calcium binding protein A6 | 0.029032 |
| SPAG9 | sperm associated antigen 9 | 0.0285712 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0279047 |
| RHEB | Ras homolog enriched in brain | 0.0277996 |
| FMR1 | fragile X mental retardation 1 | 0.0276647 |
| DSPP | dentin sialophosphoprotein | 0.0274376 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0272634 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0270326 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0264848 |
| EZR | ezrin | 0.0263395 |
| RPS4X | ribosomal protein S4, X-linked | 0.0259676 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0258641 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0257169 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0256274 |
| KIF5B | kinesin family member 5B | 0.0253046 |
| RPL19 | ribosomal protein L19 | 0.0251301 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0250308 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0249921 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0248041 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0245359 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.024348 |
| RPL11 | ribosomal protein L11 | 0.0241206 |
| MKI67 | marker of proliferation Ki-67 | 0.0240905 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.023829 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0235417 |
| SNX9 | sorting nexin 9 | 0.0233866 |
| RPL26 | ribosomal protein L26 | 0.0231947 |
| S100A10 | S100 calcium binding protein A10 | 0.0231838 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.023171 |
| NCKAP1 | NCK-associated protein 1 | 0.0230556 |
| YBX1 | Y box binding protein 1 | 0.0228535 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0227996 |
| CALR | calreticulin | 0.0226667 |
| YME1L1 | YME1-like 1 ATPase | 0.0224981 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 0.0224171 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0224128 |
| RPL8 | ribosomal protein L8 | 0.0223835 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0223279 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0223233 |
| RPL18 | ribosomal protein L18 | 0.0221513 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0220145 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0219273 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0217263 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.0216927 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0216218 |
| RPL12 | ribosomal protein L12 | 0.0216145 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0214977 |
| SET | SET nuclear proto-oncogene | 0.021489 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAML2 | mastermind-like 2 (Drosophila) | -0.0863098 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.07155 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0650257 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0605265 |
| VCL | vinculin | -0.0597333 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0523349 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0522683 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0512865 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0465579 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0455664 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0447126 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0409403 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0373222 |
| NEBL | nebulette | -0.0344166 |
| EGR1 | early growth response 1 | -0.0329006 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.032446 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0319217 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0318526 |
| PKP4 | plakophilin 4 | -0.030672 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0304845 |
| NDRG1 | N-myc downstream regulated 1 | -0.030285 |
| BCL2L1 | BCL2-like 1 | -0.0301118 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0298834 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0289868 |
| PRELID2 | PRELI domain containing 2 | -0.0289017 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0285651 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0284738 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0280188 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0278279 |
| RAD51B | RAD51 paralog B | -0.0275554 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0259445 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0254959 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.02525 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0249151 |
| RUNX1 | runt-related transcription factor 1 | -0.0248181 |
| EXOC4 | exocyst complex component 4 | -0.0241564 |
| SMYD3 | SET and MYND domain containing 3 | -0.0237449 |
| FAT1 | FAT atypical cadherin 1 | -0.0231847 |
| MYO1E | myosin IE | -0.0228638 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0224374 |
| UBAP2 | ubiquitin associated protein 2 | -0.0222044 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0221641 |
| INTS6 | integrator complex subunit 6 | -0.022005 |
| NFIA | nuclear factor I/A | -0.0217778 |
| FRMD5 | FERM domain containing 5 | -0.0206454 |
| DOCK4 | dedicator of cytokinesis 4 | -0.020625 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0204592 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0203031 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0202411 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0199095 |
| SETX | senataxin | -0.0197126 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0192295 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0191912 |
| MT2A | metallothionein 2A | -0.0191739 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0189294 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0188154 |
| ATXN1 | ataxin 1 | -0.0188025 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0187873 |
| CLDN4 | claudin 4 | -0.0186471 |
| TJP1 | tight junction protein 1 | -0.0176828 |
| WWOX | WW domain containing oxidoreductase | -0.0176643 |
| FHL2 | four and a half LIM domains 2 | -0.0173967 |
| EGFR | epidermal growth factor receptor | -0.0173629 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0170042 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0167873 |
| NABP1 | nucleic acid binding protein 1 | -0.0165814 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0165385 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0162597 |
| HM13 | histocompatibility (minor) 13 | -0.0161887 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0161368 |
| GOLGB1 | golgin B1 | -0.0160897 |
| WWC1 | WW and C2 domain containing 1 | -0.0159452 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0158801 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0156445 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0155897 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0153008 |
| ZNF638 | zinc finger protein 638 | -0.0152049 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0151775 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0150994 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0149584 |
| SYT1 | synaptotagmin I | -0.0149378 |
| TMEM47 | transmembrane protein 47 | -0.0148582 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0148561 |
| FHIT | fragile histidine triad | -0.0148455 |
| USP34 | ubiquitin specific peptidase 34 | -0.0147957 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0147006 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0146273 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.014575 |
| EHBP1 | EH domain binding protein 1 | -0.0145399 |
| HDAC4 | histone deacetylase 4 | -0.0144617 |
| GPHN | gephyrin | -0.0144462 |
| TGFA | transforming growth factor, alpha | -0.0143627 |
| PRKCA | protein kinase C, alpha | -0.0143058 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0142454 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0142398 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0140567 |
| MUC13 | mucin 13, cell surface associated | -0.0140454 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0139837 |
| COG5 | component of oligomeric golgi complex 5 | -0.0139452 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0138665 |
