| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.15033 |
| ANXA1 | annexin A1 | 0.129643 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.117214 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0792979 |
| AREG | amphiregulin | 0.0792325 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0642298 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0618916 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0601835 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0583824 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0582467 |
| EZR | ezrin | 0.0513259 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0506985 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0465889 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0452507 |
| RPS4X | ribosomal protein S4, X-linked | 0.0436979 |
| GOLGA4 | golgin A4 | 0.043628 |
| MYO5B | myosin VB | 0.0427091 |
| KRT18 | keratin 18, type I | 0.0423413 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0417011 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0410358 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0402189 |
| TXNRD1 | thioredoxin reductase 1 | 0.0402165 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0395217 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0391322 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0386322 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0383935 |
| ANXA2 | annexin A2 | 0.0383364 |
| NCKAP1 | NCK-associated protein 1 | 0.0379563 |
| NDRG1 | N-myc downstream regulated 1 | 0.0375189 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0371088 |
| LAMB3 | laminin, beta 3 | 0.0365285 |
| LDHA | lactate dehydrogenase A | 0.0365127 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0360975 |
| RPL3 | ribosomal protein L3 | 0.0348834 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0346448 |
| RLF | rearranged L-myc fusion | 0.0338782 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0335441 |
| ZNF292 | zinc finger protein 292 | 0.0328179 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0324823 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0324789 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0321552 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0321029 |
| SLMAP | sarcolemma associated protein | 0.0316335 |
| YOD1 | YOD1 deubiquitinase | 0.0315523 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.030341 |
| COG5 | component of oligomeric golgi complex 5 | 0.0302217 |
| SQSTM1 | sequestosome 1 | 0.0298017 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0294888 |
| RNF145 | ring finger protein 145 | 0.0292784 |
| OXSR1 | oxidative stress responsive 1 | 0.0292608 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0291086 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0290924 |
| DSPP | dentin sialophosphoprotein | 0.0288955 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0284579 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0283622 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0280787 |
| WDR43 | WD repeat domain 43 | 0.0273516 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0272171 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0271653 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0271383 |
| CALU | calumenin | 0.0270631 |
| NUP58 | nucleoporin 58 | 0.0269594 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0268618 |
| ABHD3 | abhydrolase domain containing 3 | 0.0261094 |
| COPA | coatomer protein complex, subunit alpha | 0.0255574 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0253248 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0250067 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0249782 |
| AHNAK | AHNAK nucleoprotein | 0.0248505 |
| RPL11 | ribosomal protein L11 | 0.0244611 |
| USP3 | ubiquitin specific peptidase 3 | 0.024305 |
| PARD3 | par-3 family cell polarity regulator | 0.0242796 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0240366 |
| OGA | O-GlcNAcase | 0.0239257 |
| RBM39 | RNA binding motif protein 39 | 0.0239037 |
| SFTPA2 | surfactant protein A2 | 0.0238625 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0238065 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0237707 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0237578 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0236615 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0233785 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0233595 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0230781 |
| BBX | bobby sox homolog (Drosophila) | 0.0230431 |
| SPAG9 | sperm associated antigen 9 | 0.0229988 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0229844 |
| VMP1 | vacuole membrane protein 1 | 0.0226863 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0225801 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0225174 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0224969 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0224827 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0224523 |
| TXNIP | thioredoxin interacting protein | 0.0222703 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | 0.0222187 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0221532 |
| CDC73 | cell division cycle 73 | 0.0220177 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.022005 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0218341 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.021799 |
| USP53 | ubiquitin specific peptidase 53 | 0.0217104 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD36 | CD36 molecule (thrombospondin receptor) | -0.13048 |
| EGFR | epidermal growth factor receptor | -0.111012 |
| RAD51B | RAD51 paralog B | -0.110724 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0990171 |
| HMGA2 | high mobility group AT-hook 2 | -0.0929228 |
| FHIT | fragile histidine triad | -0.0670319 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0631028 |
| LAMA4 | laminin, alpha 4 | -0.048016 |
| VCL | vinculin | -0.0479891 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0475515 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0454006 |
| OXR1 | oxidation resistance 1 | -0.0445307 |
| FERMT1 | fermitin family member 1 | -0.0406518 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0396105 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.038945 |
| EXOC4 | exocyst complex component 4 | -0.038293 |
| RPL35A | ribosomal protein L35a | -0.0379171 |
| ZNRF3 | zinc and ring finger 3 | -0.0365512 |
| PHF14 | PHD finger protein 14 | -0.0365372 |
| SMYD3 | SET and MYND domain containing 3 | -0.0364928 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0355492 |
| MTAP | methylthioadenosine phosphorylase | -0.0343745 |
| TNS3 | tensin 3 | -0.034048 |
| EHBP1 | EH domain binding protein 1 | -0.0333801 |
| CUX1 | cut-like homeobox 1 | -0.0331855 |
| RPS24 | ribosomal protein S24 | -0.0327025 |
| ATXN1 | ataxin 1 | -0.0321815 |
| FHL2 | four and a half LIM domains 2 | -0.0319667 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.0317297 |
| KITLG | KIT ligand | -0.0314637 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0306047 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0301799 |
| ACTG1 | actin gamma 1 | -0.0301429 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0296711 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0284629 |
| GPHN | gephyrin | -0.0281267 |
| S100A6 | S100 calcium binding protein A6 | -0.0272746 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0271204 |
| SMAD3 | SMAD family member 3 | -0.0269685 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0256428 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0255784 |
| EGR1 | early growth response 1 | -0.0252413 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0247726 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0246731 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0239731 |
| BCL2L1 | BCL2-like 1 | -0.0239681 |
| BMP4 | bone morphogenetic protein 4 | -0.0232213 |
| HDAC2 | histone deacetylase 2 | -0.0225289 |
| FLOT1 | flotillin 1 | -0.0221278 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0220492 |
| AOPEP | aminopeptidase O (putative) | -0.0219977 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0218082 |
| RPS8 | ribosomal protein S8 | -0.0216154 |
| RCOR1 | REST corepressor 1 | -0.0212718 |
| RPS25 | ribosomal protein S25 | -0.0211666 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0198759 |
| RPL34 | ribosomal protein L34 | -0.019733 |
| RPS19 | ribosomal protein S19 | -0.0196501 |
| PTMA | prothymosin, alpha | -0.0195051 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.0193876 |
| HDAC4 | histone deacetylase 4 | -0.0192763 |
| EDAR | ectodysplasin A receptor | -0.0189777 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0188568 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0188222 |
| TENM3 | teneurin transmembrane protein 3 | -0.0188081 |
| SEPTIN9 | septin 9 | -0.0186199 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0185921 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0185808 |
| WWOX | WW domain containing oxidoreductase | -0.0184782 |
| SPATA13 | spermatogenesis associated 13 | -0.0183771 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0181898 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0181383 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0176194 |
| UTRN | utrophin | -0.0172854 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0172733 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0172597 |
| JMJD1C | jumonji domain containing 1C | -0.0172214 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0169849 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0169667 |
| CD9 | CD9 molecule | -0.0167404 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0166802 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0166391 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0166289 |
| TMEM123 | transmembrane protein 123 | -0.0163685 |
| FRMD5 | FERM domain containing 5 | -0.0161937 |
| CMIP | c-Maf inducing protein | -0.0161345 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0160797 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0160762 |
| PKP4 | plakophilin 4 | -0.0158701 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.015847 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.015842 |
| RPL9 | ribosomal protein L9 | -0.0156996 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0156897 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0156591 |
| ACTN4 | actinin, alpha 4 | -0.0156085 |
| ABR | active BCR-related | -0.015499 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.0152484 |
| EFNB2 | ephrin-B2 | -0.0152282 |
| CDK13 | cyclin-dependent kinase 13 | -0.0151109 |
| KLK10 | kallikrein-related peptidase 10 | -0.0150766 |
