| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT18 | keratin 18, type I | 0.189992 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.15878 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.115179 |
| EZR | ezrin | 0.111404 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0819008 |
| PLEC | plectin | 0.0777202 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0752311 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0709577 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0626651 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0595626 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0532679 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0532422 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0512786 |
| EGR1 | early growth response 1 | 0.0495536 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0478875 |
| NDRG1 | N-myc downstream regulated 1 | 0.0474646 |
| ANXA2 | annexin A2 | 0.0462407 |
| ARF4 | ADP-ribosylation factor 4 | 0.04612 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.045819 |
| EMP1 | epithelial membrane protein 1 | 0.0453375 |
| GOLGA4 | golgin A4 | 0.0452446 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0438848 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0420104 |
| ITGA6 | integrin, alpha 6 | 0.0404791 |
| ITGB4 | integrin, beta 4 | 0.0380977 |
| MSN | moesin | 0.0374839 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0367318 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0360352 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0356322 |
| FLNA | filamin A, alpha | 0.0347308 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.028554 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0284509 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0282514 |
| TGM2 | transglutaminase 2 | 0.0273823 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0269321 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0262627 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0260009 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0246956 |
| COPA | coatomer protein complex, subunit alpha | 0.0245948 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0245699 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0244684 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0244502 |
| DNM2 | dynamin 2 | 0.0243813 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0243017 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0241433 |
| VEGFA | vascular endothelial growth factor A | 0.0236352 |
| FOSL1 | FOS-like antigen 1 | 0.0234204 |
| SEPTIN9 | septin 9 | 0.0226704 |
| KRT19 | keratin 19, type I | 0.0226697 |
| FNIP1 | folliculin interacting protein 1 | 0.0225985 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0225303 |
| TNS4 | tensin 4 | 0.0222309 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0221227 |
| CCNL1 | cyclin L1 | 0.0220053 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0219898 |
| TMEM41B | transmembrane protein 41B | 0.0215978 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.0215939 |
| RPS4X | ribosomal protein S4, X-linked | 0.0214078 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0212769 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0211543 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0210014 |
| SNX9 | sorting nexin 9 | 0.0206591 |
| TMF1 | TATA element modulatory factor 1 | 0.020486 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0200376 |
| OPTN | optineurin | 0.0197264 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0194537 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.019274 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0192654 |
| KRT8 | keratin 8, type II | 0.0192078 |
| RPL3 | ribosomal protein L3 | 0.0190352 |
| NUP58 | nucleoporin 58 | 0.0188445 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0187192 |
| PPL | periplakin | 0.0184936 |
| INSIG2 | insulin induced gene 2 | 0.0184794 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0184258 |
| SQSTM1 | sequestosome 1 | 0.0184228 |
| GOLGA2 | golgin A2 | 0.0182091 |
| DSPP | dentin sialophosphoprotein | 0.0181575 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0180223 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0179878 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.017944 |
| TPM4 | tropomyosin 4 | 0.0178854 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.017859 |
| SUCO | SUN domain containing ossification factor | 0.0178194 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0177061 |
| ARCN1 | archain 1 | 0.0173631 |
| ARRDC3 | arrestin domain containing 3 | 0.0171959 |
| EPHA2 | EPH receptor A2 | 0.0170874 |
| POTEF | POTE ankyrin domain family, member F | 0.0170603 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0169951 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0169333 |
| BRD2 | bromodomain containing 2 | 0.0167 |
| ADM | adrenomedullin | 0.0165701 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0165182 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0165065 |
| RIOK3 | RIO kinase 3 | 0.016433 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0162867 |
| SFTPA2 | surfactant protein A2 | 0.016202 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0161409 |
| STC2 | stanniocalcin 2 | 0.0160814 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.231241 |
| SYT1 | synaptotagmin I | -0.113751 |
| RPS27A | ribosomal protein S27a | -0.0879211 |
| TMSB10 | thymosin beta 10 | -0.0854809 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0829158 |
| PTMA | prothymosin, alpha | -0.0811722 |
| WWOX | WW domain containing oxidoreductase | -0.0777074 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0747998 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0664869 |
| RPS24 | ribosomal protein S24 | -0.0641352 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0628285 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0597378 |
| RPL23 | ribosomal protein L23 | -0.0580605 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0555355 |
| UBC | ubiquitin C | -0.0554353 |
| AOPEP | aminopeptidase O (putative) | -0.0529953 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0519436 |
| ACTN4 | actinin, alpha 4 | -0.0504548 |
| RPL26 | ribosomal protein L26 | -0.0492165 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0487959 |
| RPLP1 | ribosomal protein, large, P1 | -0.0486191 |
| RPL36A | ribosomal protein L36a | -0.0482225 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0480101 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0479928 |
| ENO1 | enolase 1, (alpha) | -0.0477884 |
| RPS8 | ribosomal protein S8 | -0.0475507 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0472824 |
| RPL35A | ribosomal protein L35a | -0.0471931 |
| SMYD3 | SET and MYND domain containing 3 | -0.0466225 |
| OXR1 | oxidation resistance 1 | -0.046311 |
| TNS3 | tensin 3 | -0.0454191 |
| RUNX1 | runt-related transcription factor 1 | -0.0433806 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0431296 |
| RAD51B | RAD51 paralog B | -0.0408351 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0405553 |
| PHF14 | PHD finger protein 14 | -0.0404967 |
| VIM | vimentin | -0.0392973 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.039176 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0390137 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0386796 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0385132 |
| GPHN | gephyrin | -0.0376643 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0376042 |
| RPS3 | ribosomal protein S3 | -0.0375873 |
| RPL5 | ribosomal protein L5 | -0.0373867 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0371133 |
| RBM39 | RNA binding motif protein 39 | -0.0370732 |
| EHBP1 | EH domain binding protein 1 | -0.0369788 |
| AHNAK | AHNAK nucleoprotein | -0.0368753 |
| RPLP2 | ribosomal protein, large, P2 | -0.0363606 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0362439 |
| RPS12 | ribosomal protein S12 | -0.0361947 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0359709 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0359268 |
| PROX1 | prospero homeobox 1 | -0.034978 |
| HMGB1 | high mobility group box 1 | -0.0349293 |
| DST | dystonin | -0.0345923 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0344954 |
| MYO1D | myosin ID | -0.0340751 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0337479 |
| MTAP | methylthioadenosine phosphorylase | -0.0336192 |
| RPS19 | ribosomal protein S19 | -0.033548 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0334517 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0333915 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0333734 |
| TCF12 | transcription factor 12 | -0.0331242 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0328254 |
| RPL37A | ribosomal protein L37a | -0.0328229 |
| BPTF | bromodomain PHD finger transcription factor | -0.0327014 |
| RPL38 | ribosomal protein L38 | -0.0324452 |
| RPL9 | ribosomal protein L9 | -0.0322184 |
| ZNRF3 | zinc and ring finger 3 | -0.0320394 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0320234 |
| ACTG1 | actin gamma 1 | -0.0317865 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.0316289 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0315007 |
| MSI2 | musashi RNA-binding protein 2 | -0.0314921 |
| PCBP2 | poly(rC) binding protein 2 | -0.0314696 |
| HDAC8 | histone deacetylase 8 | -0.0314595 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0314418 |
| RPL4 | ribosomal protein L4 | -0.0314249 |
| RPS23 | ribosomal protein S23 | -0.0313505 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0310351 |
| TMEM163 | transmembrane protein 163 | -0.0309894 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.030787 |
| CDK6 | cyclin-dependent kinase 6 | -0.0306896 |
| RPS21 | ribosomal protein S21 | -0.0305814 |
| IPO7 | importin 7 | -0.0305271 |
| CDH13 | cadherin 13 | -0.030256 |
| FOXP1 | forkhead box P1 | -0.0301232 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0300709 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0299615 |
| YAP1 | Yes-associated protein 1 | -0.0299344 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0296962 |
| EXOC4 | exocyst complex component 4 | -0.0296252 |
| DIAPH2 | diaphanous-related formin 2 | -0.0288896 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0288035 |
| TASP1 | taspase, threonine aspartase, 1 | -0.0287162 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0286852 |
| NAV2 | neuron navigator 2 | -0.0286159 |
