Tirabrutinib (hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.110652
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0958069
VIM vimentin 0.0903695
HLA-B major histocompatibility complex, class I, B 0.0847462
B2M beta-2-microglobulin 0.078017
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0689935
MYH9 myosin, heavy chain 9, non-muscle 0.0643409
GOLGA4 golgin A4 0.0625602
EEF2 eukaryotic translation elongation factor 2 0.0590432
ADM adrenomedullin 0.0551597
CALR calreticulin 0.0487448
FTH1 ferritin, heavy polypeptide 1 0.0455284
FTL ferritin, light polypeptide 0.0448548
TM4SF1 transmembrane 4 L six family member 1 0.0419111
RPS6 ribosomal protein S6 0.0398684
TPT1 tumor protein, translationally-controlled 1 0.0392032
SOD2 superoxide dismutase 2, mitochondrial 0.0387014
EIF1 eukaryotic translation initiation factor 1 0.0387008
PTMA prothymosin, alpha 0.0370323
MT2A metallothionein 2A 0.0365948
HLA-A major histocompatibility complex, class I, A 0.0360293
CALU calumenin 0.0324439
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0317799
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0313543
COL6A1 collagen, type VI, alpha 1 0.0298668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0296353
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.027602
SPAG9 sperm associated antigen 9 0.0274654
STC1 stanniocalcin 1 0.0268944
CANX calnexin 0.0260485
PRRC2C proline-rich coiled-coil 2C 0.0259649
RPL11 ribosomal protein L11 0.0252611
TTC3 tetratricopeptide repeat domain 3 0.0251901
RPS12 ribosomal protein S12 0.025081
HLA-E major histocompatibility complex, class I, E 0.0241244
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0234545
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229734
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0229301
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0229105
RPS8 ribosomal protein S8 0.0226658
SFTPA2 surfactant protein A2 0.0226017
YBX1 Y box binding protein 1 0.0225852
AKAP9 A kinase (PRKA) anchor protein 9 0.0224079
RPS19 ribosomal protein S19 0.0220393
RPL19 ribosomal protein L19 0.021898
ALCAM activated leukocyte cell adhesion molecule 0.0209891
SEC31A SEC31 homolog A (S. cerevisiae) 0.020824
BHLHE40 basic helix-loop-helix family, member e40 0.0206914
POTEF POTE ankyrin domain family, member F 0.0203945
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0203756
NUP58 nucleoporin 58 0.020252
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0201574
FLNA filamin A, alpha 0.0201557
GOLGB1 golgin B1 0.0195277
DST dystonin 0.019498
PDIA3 protein disulfide isomerase family A, member 3 0.019228
TPM4 tropomyosin 4 0.0192193
RPL37A ribosomal protein L37a 0.0183814
RPS13 ribosomal protein S13 0.0181904
FAM13A family with sequence similarity 13, member A 0.0181073
STC2 stanniocalcin 2 0.0180243
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0179676
RND3 Rho family GTPase 3 0.017922
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0177111
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0176746
RPL12 ribosomal protein L12 0.0175908
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0173381
RPLP1 ribosomal protein, large, P1 0.0172866
HILPDA hypoxia inducible lipid droplet-associated 0.0171712
NAP1L1 nucleosome assembly protein 1-like 1 0.0170908
LMNA lamin A/C 0.0170274
BRD2 bromodomain containing 2 0.0169575
RPS4X ribosomal protein S4, X-linked 0.0169541
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.016614
RPL23 ribosomal protein L23 0.0164242
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0163668
TMF1 TATA element modulatory factor 1 0.0163235
COPA coatomer protein complex, subunit alpha 0.0162128
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0159196
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0158421
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0158287
SRRM2 serine/arginine repetitive matrix 2 0.0157009
DSCAM Down syndrome cell adhesion molecule 0.0156416
OPTN optineurin 0.0156108
ENO1 enolase 1, (alpha) 0.0155769
UGCG UDP-glucose ceramide glucosyltransferase 0.0155591
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0155353
RPS11 ribosomal protein S11 0.0152907
FNIP1 folliculin interacting protein 1 0.0152816
KDM3A lysine (K)-specific demethylase 3A 0.0151578
TFPI2 tissue factor pathway inhibitor 2 0.0150693
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0150141
TPM2 tropomyosin 2 (beta) 0.0149687
SQSTM1 sequestosome 1 0.014941
TRIO trio Rho guanine nucleotide exchange factor 0.0149277
HELZ helicase with zinc finger 0.014879
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0146845
RPL5 ribosomal protein L5 0.0145749
NPTX1 neuronal pentraxin I 0.0145667
ATF4 activating transcription factor 4 0.0145237

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.135237
NALF1 NALCN channel auxiliary factor 1 -0.0645505
HMGA2 high mobility group AT-hook 2 -0.0604061
ADGRB3 adhesion G protein-coupled receptor B3 -0.0574856
INHBA inhibin, beta A -0.0485445
ATP13A3 ATPase type 13A3 -0.0387221
OXR1 oxidation resistance 1 -0.0366167
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0354358
FNDC3B fibronectin type III domain containing 3B -0.0336626
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0331554
EGFR epidermal growth factor receptor -0.0323015
NAV1 neuron navigator 1 -0.0320767
LOXL2 lysyl oxidase-like 2 -0.032034
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0308421
COL1A2 collagen, type I, alpha 2 -0.030174
MYO10 myosin X -0.0295462
RAI14 retinoic acid induced 14 -0.0290875
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0285947
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0283843
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0281371
ABI3BP ABI family, member 3 (NESH) binding protein -0.0273591
GLIS3 GLIS family zinc finger 3 -0.0270917
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0257862
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0251679
FRMD4A FERM domain containing 4A -0.0249321
CD44 CD44 molecule (Indian blood group) -0.0247036
SMAD3 SMAD family member 3 -0.0245999
AKAP12 A kinase (PRKA) anchor protein 12 -0.0229181
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0228289
EXT1 exostosin glycosyltransferase 1 -0.0222448
COL1A1 collagen, type I, alpha 1 -0.0220484
ASPH aspartate beta-hydroxylase -0.0220382
PLPP3 phospholipid phosphatase 3 -0.0195198
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0177703
DIAPH2 diaphanous-related formin 2 -0.0176151
OSMR oncostatin M receptor -0.0167847
ELL2 elongation factor, RNA polymerase II, 2 -0.0162389
JARID2 jumonji, AT rich interactive domain 2 -0.0156894
PDE8A phosphodiesterase 8A -0.0156426
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0149031
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0146129
ARHGAP24 Rho GTPase activating protein 24 -0.0141538
COL5A3 collagen, type V, alpha 3 -0.0139853
FRMD6 FERM domain containing 6 -0.013535
TSHZ3 teashirt zinc finger homeobox 3 -0.01349
ZEB1 zinc finger E-box binding homeobox 1 -0.0134541
RUNX1 runt-related transcription factor 1 -0.0132188
WNT5A wingless-type MMTV integration site family, member 5A -0.0131424
SPRED2 sprouty-related, EVH1 domain containing 2 -0.013058
KIAA1549L KIAA1549-like -0.0125877
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0125501
PDGFRB platelet-derived growth factor receptor, beta polypeptide -0.0123051
PDE4B phosphodiesterase 4B, cAMP-specific -0.0121918
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.012177
NT5E 5'-nucleotidase, ecto (CD73) -0.0116891
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0116713
SPRY4 sprouty homolog 4 (Drosophila) -0.0116685
MTSS1 metastasis suppressor 1 -0.0114836
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0110071
CCDC102B coiled-coil domain containing 102B -0.0108962
CPA6 carboxypeptidase A6 -0.0108466
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0107584
EPAS1 endothelial PAS domain protein 1 -0.0107567
SASH1 SAM and SH3 domain containing 1 -0.0107373
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0104025
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0102093
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0101364
SOCS5 suppressor of cytokine signaling 5 -0.0100982
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0100079
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0100045
PARVA parvin, alpha -0.00998755
LTBP1 latent transforming growth factor beta binding protein 1 -0.00996946
RNF152 ring finger protein 152 -0.00988058
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0098242
SEPTIN11 septin 11 -0.00958082
MAML2 mastermind-like 2 (Drosophila) -0.00957893
PCBP3 poly(rC) binding protein 3 -0.00935496
GREM1 gremlin 1, DAN family BMP antagonist -0.00933593
LOX lysyl oxidase -0.00925101
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -0.00925072
COL6A2 collagen, type VI, alpha 2 -0.00918552
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0091649
BAALC brain and acute leukemia, cytoplasmic -0.00905561
COL8A1 collagen, type VIII, alpha 1 -0.00899836
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.00895344
PAMR1 peptidase domain containing associated with muscle regeneration 1 -0.00887266
VCL vinculin -0.00880636
NRP1 neuropilin 1 -0.00879925
FBXL17 F-box and leucine-rich repeat protein 17 -0.00876839
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.00875587
KLF7 Kruppel-like factor 7 (ubiquitous) -0.00856437
BBS9 Bardet-Biedl syndrome 9 -0.00856079
VEGFC vascular endothelial growth factor C -0.00854485
CD59 CD59 molecule, complement regulatory protein -0.00833189
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.00815541
MMP1 matrix metallopeptidase 1 -0.00815531
THBS2 thrombospondin 2 -0.00807798
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.00804789
PHC2 polyhomeotic homolog 2 (Drosophila) -0.00791342
SMOX spermine oxidase -0.00777946