| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.271311 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.218131 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.175796 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.149719 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.134521 |
| PLAT | plasminogen activator, tissue | 0.128195 |
| FNDC3B | fibronectin type III domain containing 3B | 0.120763 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.117854 |
| FLNB | filamin B, beta | 0.113508 |
| NAV1 | neuron navigator 1 | 0.110592 |
| CD44 | CD44 molecule (Indian blood group) | 0.105234 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0951335 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0896322 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0880241 |
| PODXL | podocalyxin-like | 0.0819458 |
| ANXA2 | annexin A2 | 0.080227 |
| MYOF | myoferlin | 0.0793365 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0788708 |
| DST | dystonin | 0.0733734 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0706427 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0649857 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0647726 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0639915 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0630399 |
| RUNX1 | runt-related transcription factor 1 | 0.0622162 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0591675 |
| MB21D2 | Mab-21 domain containing 2 | 0.0538326 |
| PRELID2 | PRELI domain containing 2 | 0.0532206 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.051003 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0506441 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.049024 |
| C1D | C1D nuclear receptor corepressor | 0.0489866 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0471676 |
| SEPTIN9 | septin 9 | 0.0465527 |
| RTN4 | reticulon 4 | 0.0459993 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0459263 |
| VCL | vinculin | 0.0453569 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0446119 |
| LDHA | lactate dehydrogenase A | 0.0445597 |
| ANO6 | anoctamin 6 | 0.0418305 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0410206 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0410165 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0406745 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0406169 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0402849 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0401136 |
| APP | amyloid beta (A4) precursor protein | 0.0390777 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0388315 |
| ASPH | aspartate beta-hydroxylase | 0.0388194 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0387242 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0379635 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0379099 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0370523 |
| NOTCH2 | notch 2 | 0.0367779 |
| LOXL2 | lysyl oxidase-like 2 | 0.035806 |
| YEATS2 | YEATS domain containing 2 | 0.0344467 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0344386 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0343816 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0341273 |
| SMAD3 | SMAD family member 3 | 0.0339664 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0338795 |
| TPM3 | tropomyosin 3 | 0.0335102 |
| RAI14 | retinoic acid induced 14 | 0.0334271 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0332543 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0328877 |
| NAV2 | neuron navigator 2 | 0.0326966 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0326448 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0316778 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0316643 |
| FLNA | filamin A, alpha | 0.0313003 |
| ZNF292 | zinc finger protein 292 | 0.0310913 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0310021 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0309734 |
| HDAC9 | histone deacetylase 9 | 0.0309692 |
| MSN | moesin | 0.0304356 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0301424 |
| UBAP1 | ubiquitin associated protein 1 | 0.0295143 |
| XPO1 | exportin 1 | 0.0293645 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0293195 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0292892 |
| VMP1 | vacuole membrane protein 1 | 0.0290861 |
| NDRG1 | N-myc downstream regulated 1 | 0.0290187 |
| OGA | O-GlcNAcase | 0.0290115 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0288135 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0284262 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0283761 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.028371 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0281395 |
| LOX | lysyl oxidase | 0.028106 |
| PKM | pyruvate kinase, muscle | 0.0279692 |
| ZNF148 | zinc finger protein 148 | 0.0277473 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0276439 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0276161 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0274813 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0269827 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0268201 |
| PFKP | phosphofructokinase, platelet | 0.0267551 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0265744 |
| SMYD3 | SET and MYND domain containing 3 | 0.0264794 |
| HELZ | helicase with zinc finger | 0.026454 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.140568 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0949966 |
| TMSB10 | thymosin beta 10 | -0.0935144 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0927708 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0836046 |
| PTMA | prothymosin, alpha | -0.0550106 |
| SUCNR1 | succinate receptor 1 | -0.054693 |
| S100A6 | S100 calcium binding protein A6 | -0.0528716 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0497996 |
| LMNA | lamin A/C | -0.0494434 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0466382 |
| HLA-B | major histocompatibility complex, class I, B | -0.0438982 |
| CANX | calnexin | -0.0435877 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0434192 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0384507 |
| COL1A2 | collagen, type I, alpha 2 | -0.0358733 |
| MEIS2 | Meis homeobox 2 | -0.0357678 |
| HLA-E | major histocompatibility complex, class I, E | -0.0355265 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0349544 |
| GOLGA4 | golgin A4 | -0.0348673 |
| MT2A | metallothionein 2A | -0.0347773 |
| CSTB | cystatin B (stefin B) | -0.0342025 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.033198 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0328299 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0324979 |
| PRSS23 | protease, serine, 23 | -0.0320791 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0316656 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.031509 |
| CALR | calreticulin | -0.0313212 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0311517 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0298443 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0297178 |
| PRRX1 | paired related homeobox 1 | -0.0294432 |
| INSIG1 | insulin induced gene 1 | -0.0291096 |
| FRMD5 | FERM domain containing 5 | -0.0279997 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0277344 |
| SLFN5 | schlafen family member 5 | -0.0272396 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.02546 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0254054 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.024659 |
| RRBP1 | ribosome binding protein 1 | -0.0245414 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0237884 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0237768 |
| TBCA | tubulin folding cofactor A | -0.0234311 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0228009 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0227663 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0226663 |
| CDK14 | cyclin-dependent kinase 14 | -0.0223208 |
| UBXN4 | UBX domain protein 4 | -0.0222556 |
| FRMD4A | FERM domain containing 4A | -0.0218083 |
| B2M | beta-2-microglobulin | -0.0215284 |
| S100A4 | S100 calcium binding protein A4 | -0.0206523 |
| CAVIN1 | caveolae associated protein 1 | -0.0205172 |
| JAZF1 | JAZF zinc finger 1 | -0.0203551 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.0203077 |
| PARD3 | par-3 family cell polarity regulator | -0.0202135 |
| GOLGA2 | golgin A2 | -0.0201382 |
| TPM4 | tropomyosin 4 | -0.020005 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.01991 |
| COL1A1 | collagen, type I, alpha 1 | -0.0195666 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0194984 |
| CDK13 | cyclin-dependent kinase 13 | -0.019467 |
| HM13 | histocompatibility (minor) 13 | -0.019345 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0191626 |
| IL7R | interleukin 7 receptor | -0.0186296 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0185387 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.018528 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0184641 |
| SYT1 | synaptotagmin I | -0.0182317 |
| FN1 | fibronectin 1 | -0.0181445 |
| SQSTM1 | sequestosome 1 | -0.0179998 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.017988 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0178109 |
| BRD4 | bromodomain containing 4 | -0.0177674 |
| CBX3 | chromobox homolog 3 | -0.0177448 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | -0.0177107 |
| HDLBP | high density lipoprotein binding protein | -0.0176308 |
| COL3A1 | collagen, type III, alpha 1 | -0.0176287 |
| TMSB4X | thymosin beta 4, X-linked | -0.0175531 |
| CDH13 | cadherin 13 | -0.0173124 |
| CLINT1 | clathrin interactor 1 | -0.0172082 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0171482 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0170945 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0170929 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0169795 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0165449 |
| CD63 | CD63 molecule | -0.0164594 |
| THY1 | Thy-1 cell surface antigen | -0.0164477 |
| FTL | ferritin, light polypeptide | -0.0164295 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0163539 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0163535 |
| CALU | calumenin | -0.016248 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.016185 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0161544 |
| ATXN2 | ataxin 2 | -0.0161064 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0159696 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0159096 |
| ACTG1 | actin gamma 1 | -0.015876 |
| CD99 | CD99 molecule | -0.0157693 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0156449 |
