| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.220084 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.19754 |
| DST | dystonin | 0.141698 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.131674 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.118737 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.106943 |
| MMP12 | matrix metallopeptidase 12 | 0.0997474 |
| ANXA1 | annexin A1 | 0.0953772 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0943314 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0939048 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0924168 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0865172 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0839487 |
| SLC38A2 | solute carrier family 38, member 2 | 0.080792 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0783942 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0713282 |
| ENO1 | enolase 1, (alpha) | 0.0713098 |
| LDHA | lactate dehydrogenase A | 0.0710786 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0699043 |
| MED13L | mediator complex subunit 13-like | 0.0698475 |
| TXNRD1 | thioredoxin reductase 1 | 0.0679864 |
| PGK1 | phosphoglycerate kinase 1 | 0.0675166 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0645879 |
| TMEM41B | transmembrane protein 41B | 0.0637225 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0633569 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.060562 |
| LMO7 | LIM domain 7 | 0.0605181 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0563062 |
| NEBL | nebulette | 0.0558103 |
| SBF2 | SET binding factor 2 | 0.0538122 |
| VMP1 | vacuole membrane protein 1 | 0.0531405 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0525538 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0523289 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0500844 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0500312 |
| ZNF292 | zinc finger protein 292 | 0.0499595 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0499314 |
| CENPF | centromere protein F, 350/400kDa | 0.0496674 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0495953 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0487792 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0480469 |
| RPL4 | ribosomal protein L4 | 0.0477013 |
| AXIN2 | axin 2 | 0.047115 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0469169 |
| XPO1 | exportin 1 | 0.0463936 |
| SMYD3 | SET and MYND domain containing 3 | 0.0460329 |
| NEK7 | NIMA-related kinase 7 | 0.0458827 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0456052 |
| IL6ST | interleukin 6 signal transducer | 0.0455977 |
| KIF5B | kinesin family member 5B | 0.0452347 |
| JMJD1C | jumonji domain containing 1C | 0.045188 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0451333 |
| XPOT | exportin, tRNA | 0.0450811 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.044931 |
| POTEF | POTE ankyrin domain family, member F | 0.0448803 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0433904 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0431283 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0424546 |
| ECT2 | epithelial cell transforming 2 | 0.0423883 |
| EZR | ezrin | 0.0413568 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0411435 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.041082 |
| MKI67 | marker of proliferation Ki-67 | 0.0409107 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0407453 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.040634 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0404781 |
| FAT1 | FAT atypical cadherin 1 | 0.0403552 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.040028 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0393265 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0391134 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0390749 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.039008 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0388016 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0387134 |
| RHOA | ras homolog family member A | 0.0385228 |
| OGA | O-GlcNAcase | 0.0384225 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0378458 |
| RPL3 | ribosomal protein L3 | 0.0376572 |
| USP34 | ubiquitin specific peptidase 34 | 0.0374272 |
| VCL | vinculin | 0.0372615 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0370922 |
| FNIP1 | folliculin interacting protein 1 | 0.0370662 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0367711 |
| YAP1 | Yes-associated protein 1 | 0.0366989 |
| YEATS2 | YEATS domain containing 2 | 0.0363568 |
| ASPH | aspartate beta-hydroxylase | 0.0349858 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0349761 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0348981 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.034823 |
| RTN4 | reticulon 4 | 0.0347752 |
| CDK17 | cyclin-dependent kinase 17 | 0.0347487 |
| IPO7 | importin 7 | 0.0347362 |
| ERBIN | erbb2 interacting protein | 0.0346496 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0345111 |
| TPM3 | tropomyosin 3 | 0.0344849 |
| TPD52 | tumor protein D52 | 0.0338705 |
| PCM1 | pericentriolar material 1 | 0.0335328 |
| DTNA | dystrobrevin, alpha | 0.0332103 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0331628 |
| TBK1 | TANK-binding kinase 1 | 0.0330027 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.108654 |
| TMSB10 | thymosin beta 10 | -0.0642803 |
| HMGA2 | high mobility group AT-hook 2 | -0.0580231 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0517115 |
| INTS6 | integrator complex subunit 6 | -0.0479444 |
| ADIPOR2 | adiponectin receptor 2 | -0.0391395 |
| RPS19 | ribosomal protein S19 | -0.0308751 |
| EDN1 | endothelin 1 | -0.0291516 |
| RPLP1 | ribosomal protein, large, P1 | -0.028627 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0256756 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | -0.0256455 |
| DENND5A | DENN/MADD domain containing 5A | -0.0250141 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0249417 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0246907 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0242589 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0235997 |
| POU2F1 | POU class 2 homeobox 1 | -0.0234749 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0234202 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0233705 |
| CUX1 | cut-like homeobox 1 | -0.0231637 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0231365 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0230146 |
| FUS | FUS RNA binding protein | -0.0229508 |
| HELLS | helicase, lymphoid-specific | -0.0220638 |
| RPS21 | ribosomal protein S21 | -0.0220631 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0219819 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0217804 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0212651 |
| RPL36 | ribosomal protein L36 | -0.0206078 |
| PFN1 | profilin 1 | -0.0204905 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0199646 |
| PTMS | parathymosin | -0.0198175 |
| INTS4 | integrator complex subunit 4 | -0.0196773 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0196718 |
| TBCA | tubulin folding cofactor A | -0.0196602 |
| RPS27A | ribosomal protein S27a | -0.0193905 |
| HMGB1 | high mobility group box 1 | -0.0191706 |
| RPL23 | ribosomal protein L23 | -0.0189856 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0189022 |
| RASAL2 | RAS protein activator like 2 | -0.0188247 |
| LARP4 | La ribonucleoprotein domain family, member 4 | -0.0188023 |
| E2F3 | E2F transcription factor 3 | -0.0186715 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0186065 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0182396 |
| RPS6 | ribosomal protein S6 | -0.0181486 |
| SKI | SKI proto-oncogene | -0.0178976 |
| PCDH9 | protocadherin 9 | -0.0178758 |
| EHBP1 | EH domain binding protein 1 | -0.0176263 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0174521 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0174157 |
| AEBP2 | AE binding protein 2 | -0.0171801 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0170403 |
| UBAP2 | ubiquitin associated protein 2 | -0.0169027 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0168859 |
| RTN3 | reticulon 3 | -0.0167379 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0167073 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0163085 |
| TMEM181 | transmembrane protein 181 | -0.0162591 |
| DUSP16 | dual specificity phosphatase 16 | -0.0161962 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0161431 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0161243 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0161052 |
| NUP98 | nucleoporin 98kDa | -0.0160922 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.015853 |
| TTC27 | tetratricopeptide repeat domain 27 | -0.0157233 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0156915 |
| CDK13 | cyclin-dependent kinase 13 | -0.0156505 |
| SPAG16 | sperm associated antigen 16 | -0.015646 |
| LRRC23 | leucine rich repeat containing 23 | -0.0155342 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0154174 |
| NHSL1 | NHS-like 1 | -0.0153723 |
| RBM25 | RNA binding motif protein 25 | -0.015371 |
| RPL27A | ribosomal protein L27a | -0.0153694 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.0149945 |
| R3HDM2 | R3H domain containing 2 | -0.0148298 |
| RPS20 | ribosomal protein S20 | -0.0147879 |
| RAB31 | RAB31, member RAS oncogene family | -0.0147736 |
| NAV3 | neuron navigator 3 | -0.0147485 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0146597 |
| FANCA | Fanconi anemia, complementation group A | -0.0145931 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0144957 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0143974 |
| HDAC8 | histone deacetylase 8 | -0.0142704 |
| EEFSEC | eukaryotic elongation factor, selenocysteine-tRNA-specific | -0.0141514 |
| B2M | beta-2-microglobulin | -0.0141163 |
| RSU1 | Ras suppressor protein 1 | -0.0139136 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.013893 |
| RCC1 | regulator of chromosome condensation 1 | -0.0138187 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.013794 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0136556 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0136154 |
| TFRC | transferrin receptor | -0.0135125 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0134898 |
| TTC33 | tetratricopeptide repeat domain 33 | -0.0133583 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0133551 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0133486 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.0133149 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0132076 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.013149 |
| SRSF2 | serine/arginine-rich splicing factor 2 | -0.0131081 |
