Tirabrutinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.104933
MEIS2 Meis homeobox 2 0.0960387
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0871281
DPH6 diphthamine biosynthesis 6 0.0862148
DST dystonin 0.0830287
FAM13A family with sequence similarity 13, member A 0.0727101
PTPRD protein tyrosine phosphatase, receptor type, D 0.0689881
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0689806
NRIP1 nuclear receptor interacting protein 1 0.0687197
TLE4 transducin-like enhancer of split 4 0.0658277
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0657983
FMN1 formin 1 0.0648273
TRIO trio Rho guanine nucleotide exchange factor 0.0621034
LIMCH1 LIM and calponin homology domains 1 0.0578365
HELZ helicase with zinc finger 0.0547487
ITPRID2 ITPR interacting domain containing 2 0.0507321
SOS1 son of sevenless homolog 1 (Drosophila) 0.0494373
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0481698
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0478122
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0430392
MEF2A myocyte enhancer factor 2A 0.0421631
PSD3 pleckstrin and Sec7 domain containing 3 0.0419776
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0418425
PTPRM protein tyrosine phosphatase, receptor type, M 0.0405194
FNBP1 formin binding protein 1 0.0384286
FNDC3B fibronectin type III domain containing 3B 0.0373475
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0353583
ADGRG6 adhesion G protein-coupled receptor G6 0.0348722
PLAT plasminogen activator, tissue 0.0343656
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0343485
SH3RF1 SH3 domain containing ring finger 1 0.0342473
SMAD3 SMAD family member 3 0.0333777
ANGPT1 angiopoietin 1 0.0327011
ZNF292 zinc finger protein 292 0.0319705
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0318691
ZFC3H1 zinc finger, C3H1-type containing 0.0315479
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0303894
ZBTB20 zinc finger and BTB domain containing 20 0.0302126
YEATS2 YEATS domain containing 2 0.0296848
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0295519
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.028264
APP amyloid beta (A4) precursor protein 0.0278884
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0276589
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0275407
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0275158
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.027255
SSBP3 single stranded DNA binding protein 3 0.027229
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0270711
SPAG9 sperm associated antigen 9 0.0267113
SPTBN1 spectrin, beta, non-erythrocytic 1 0.02633
AOPEP aminopeptidase O (putative) 0.026149
CDK19 cyclin-dependent kinase 19 0.0260206
PELI1 pellino E3 ubiquitin protein ligase 1 0.0256082
NEK7 NIMA-related kinase 7 0.0252442
PRKD1 protein kinase D1 0.0250869
KIAA1217 KIAA1217 0.0250519
CEP95 centrosomal protein 95kDa 0.0249438
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0246925
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0246132
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0243156
DNMBP dynamin binding protein 0.0239739
AFF4 AF4/FMR2 family, member 4 0.023876
AFDN afadin, adherens junction formation factor 0.0238031
ARHGAP9 Rho GTPase activating protein 9 0.0237625
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0232624
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0230071
RAD51B RAD51 paralog B 0.0226229
PCBP3 poly(rC) binding protein 3 0.0222376
NCOR2 nuclear receptor corepressor 2 0.0221607
MYO6 myosin VI 0.022095
TCF12 transcription factor 12 0.0220782
MAML2 mastermind-like 2 (Drosophila) 0.0216927
RNF213 ring finger protein 213 0.0216574
ANK2 ankyrin 2, neuronal 0.0215785
RUNX1 runt-related transcription factor 1 0.0211831
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0211528
SOX9 SRY (sex determining region Y)-box 9 0.0210393
FNIP1 folliculin interacting protein 1 0.0209183
ETNK1 ethanolamine kinase 1 0.0209116
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0208142
CENPF centromere protein F, 350/400kDa 0.0207202
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0206782
PEAK1 pseudopodium-enriched atypical kinase 1 0.020582
CEMIP2 cell migration inducing hyaluronidase 2 0.0201775
CADM1 cell adhesion molecule 1 0.0200132
BABAM2 BRISC and BRCA1 A complex member 2 0.0200073
ANTXR1 anthrax toxin receptor 1 0.0199081
FOXO3 forkhead box O3 0.0198812
AHR aryl hydrocarbon receptor 0.0196657
ZNF148 zinc finger protein 148 0.0196031
PDE4D phosphodiesterase 4D, cAMP-specific 0.0194092
DTNA dystrobrevin, alpha 0.0193928
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0193537
RFX7 regulatory factor X, 7 0.019331
ADAR adenosine deaminase, RNA-specific 0.019275
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0190017
LCOR ligand dependent nuclear receptor corepressor 0.0189918
C1ORF21 chromosome 1 open reading frame 21 0.0188643
PTK2 protein tyrosine kinase 2 0.0188455
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0187944

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.333016
PTMA prothymosin, alpha -0.189648
IGF2 insulin-like growth factor 2 -0.179097
VIM vimentin -0.127957
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126868
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0982743
VCL vinculin -0.0935241
ACTG1 actin gamma 1 -0.0920147
RPS6 ribosomal protein S6 -0.0899126
RPL23 ribosomal protein L23 -0.0828722
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0735703
RPLP1 ribosomal protein, large, P1 -0.065649
TPT1 tumor protein, translationally-controlled 1 -0.0601312
RPL19 ribosomal protein L19 -0.0526809
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0510448
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0510079
COL1A1 collagen, type I, alpha 1 -0.0481873
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.048146
RPL35A ribosomal protein L35a -0.0478447
RPL34 ribosomal protein L34 -0.0474715
EIF1 eukaryotic translation initiation factor 1 -0.0457612
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0444645
RPS19 ribosomal protein S19 -0.0441763
RPS24 ribosomal protein S24 -0.043437
LPIN1 lipin 1 -0.0434276
RPS3 ribosomal protein S3 -0.0432124
RPL38 ribosomal protein L38 -0.0430747
RPS8 ribosomal protein S8 -0.0413624
LMNA lamin A/C -0.0410724
TMSB10 thymosin beta 10 -0.0408097
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0396855
IER3 immediate early response 3 -0.0393814
RPL37A ribosomal protein L37a -0.0393553
TPM1 tropomyosin 1 (alpha) -0.0387228
TPM4 tropomyosin 4 -0.0384442
RPL12 ribosomal protein L12 -0.0380728
RPL31 ribosomal protein L31 -0.0377597
PDIA3 protein disulfide isomerase family A, member 3 -0.0373885
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0373743
RPLP0 ribosomal protein, large, P0 -0.036729
EXT1 exostosin glycosyltransferase 1 -0.034314
RPL7A ribosomal protein L7a -0.034192
RPS29 ribosomal protein S29 -0.0340064
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0314596
FN1 fibronectin 1 -0.0310228
FTL ferritin, light polypeptide -0.030878
EGR1 early growth response 1 -0.0299886
COL3A1 collagen, type III, alpha 1 -0.0296266
CRH corticotropin releasing hormone -0.0293742
RPL37 ribosomal protein L37 -0.0291194
RPS12 ribosomal protein S12 -0.0290137
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0286411
RPS17 ribosomal protein S17 -0.0275979
RPS16 ribosomal protein S16 -0.0274736
RPS27 ribosomal protein S27 -0.0272984
RPS25 ribosomal protein S25 -0.0270307
RPS23 ribosomal protein S23 -0.026704
RPL11 ribosomal protein L11 -0.0265757
B2M beta-2-microglobulin -0.0263811
RAB7A RAB7A, member RAS oncogene family -0.0261124
GNAS GNAS complex locus -0.0260139
RPS11 ribosomal protein S11 -0.0257992
RPL26 ribosomal protein L26 -0.0256134
RPS21 ribosomal protein S21 -0.0253428
CALR calreticulin -0.0252162
KPNB1 karyopherin (importin) beta 1 -0.0251454
RPS2 ribosomal protein S2 -0.0251252
TBX2 T-box 2 -0.0250476
RPL32 ribosomal protein L32 -0.0248011
RPL18 ribosomal protein L18 -0.0247959
HIP1 huntingtin interacting protein 1 -0.02464
GREM2 gremlin 2, DAN family BMP antagonist -0.0246293
IGFBP3 insulin-like growth factor binding protein 3 -0.0245796
CANX calnexin -0.0245376
NALF1 NALCN channel auxiliary factor 1 -0.0244812
RPS5 ribosomal protein S5 -0.0244325
RPL36 ribosomal protein L36 -0.0241785
RPLP2 ribosomal protein, large, P2 -0.023913
SIK2 salt-inducible kinase 2 -0.0237439
PRRC2C proline-rich coiled-coil 2C -0.0237024
POTEF POTE ankyrin domain family, member F -0.0236966
RACK1 receptor for activated C kinase 1 -0.0232274
MCL1 myeloid cell leukemia 1 -0.023198
KTN1 kinectin 1 (kinesin receptor) -0.0231779
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0229242
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0225375
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0223034
S100A9 S100 calcium binding protein A9 -0.0222407
EIF5B eukaryotic translation initiation factor 5B -0.0222182
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0221515
RPS14 ribosomal protein S14 -0.0220611
DCAF7 DDB1 and CUL4 associated factor 7 -0.0219226
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0218621
RAB2A RAB2A, member RAS oncogene family -0.0218571
SLC39A11 solute carrier family 39, member 11 -0.0218339
VDAC1 voltage-dependent anion channel 1 -0.0217025
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0216931
CUX1 cut-like homeobox 1 -0.0216392
RPL7 ribosomal protein L7 -0.0214534
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0212996