Tirabrutinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.200069
FNDC3B fibronectin type III domain containing 3B 0.0614371
PSD3 pleckstrin and Sec7 domain containing 3 0.052872
VEGFA vascular endothelial growth factor A 0.0502969
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0448043
PRELID2 PRELI domain containing 2 0.042266
MYH9 myosin, heavy chain 9, non-muscle 0.0373864
VMP1 vacuole membrane protein 1 0.0329271
PDLIM5 PDZ and LIM domain 5 0.0319942
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0296182
MSN moesin 0.0293662
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0283246
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0268054
WWTR1 WW domain containing transcription regulator 1 0.0256246
NRIP1 nuclear receptor interacting protein 1 0.0253496
VCL vinculin 0.0243471
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0232442
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231651
CLIC4 chloride intracellular channel 4 0.0221948
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0221388
TAPBP TAP binding protein (tapasin) 0.0208985
NAV1 neuron navigator 1 0.0208072
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0193992
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0192801
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0190092
SMAD3 SMAD family member 3 0.0188242
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0187287
DPYSL3 dihydropyrimidinase-like 3 0.0186918
NOTCH2 notch 2 0.0182989
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0182845
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0176651
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0172566
RPL3 ribosomal protein L3 0.0172054
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0170856
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0170374
COL6A3 collagen, type VI, alpha 3 0.0170079
EGFR epidermal growth factor receptor 0.0164778
ZSWIM6 zinc finger, SWIM-type containing 6 0.0161184
FBXL7 F-box and leucine-rich repeat protein 7 0.0159877
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0158374
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0157643
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.015296
FER fer (fps/fes related) tyrosine kinase 0.0148887
MBNL1 muscleblind-like splicing regulator 1 0.0148775
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0147889
ECE1 endothelin converting enzyme 1 0.0141782
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.014001
HDAC9 histone deacetylase 9 0.0139566
PGM3 phosphoglucomutase 3 0.0139089
JAK2 Janus kinase 2 0.0138644
ATXN1 ataxin 1 0.013824
BRD2 bromodomain containing 2 0.0137692
ZNF644 zinc finger protein 644 0.0135014
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0134444
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.013132
ADAM19 ADAM metallopeptidase domain 19 0.0130638
PICALM phosphatidylinositol binding clathrin assembly protein 0.0130568
NDEL1 nudE neurodevelopment protein 1-like 1 0.0119968
ASPH aspartate beta-hydroxylase 0.0119934
FLNA filamin A, alpha 0.0119466
IL6ST interleukin 6 signal transducer 0.0119125
TNS1 tensin 1 0.0118789
JAG1 jagged 1 0.0118545
CRYBG3 beta-gamma crystallin domain containing 3 0.0114739
RIGI RNA sensor RIG-I 0.0110787
GRB10 growth factor receptor-bound protein 10 0.0109284
GSK3B glycogen synthase kinase 3 beta 0.0107058
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0106646
RARB retinoic acid receptor, beta 0.0105346
FAT1 FAT atypical cadherin 1 0.0103688
GPR141 G protein-coupled receptor 141 0.0102961
FNIP1 folliculin interacting protein 1 0.0102455
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.010116
THBS1 thrombospondin 1 0.0100552
ADAM12 ADAM metallopeptidase domain 12 0.0100374
GLIS3 GLIS family zinc finger 3 0.0100039
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00992392
EPHB1 EPH receptor B1 0.00988591
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00984992
C1D C1D nuclear receptor corepressor 0.00972166
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.00968368
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00964257
SLC22A23 solute carrier family 22, member 23 0.00936657
MTSS1 metastasis suppressor 1 0.0093664
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00922773
COL4A1 collagen, type IV, alpha 1 0.00916017
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0091387
MBD5 methyl-CpG binding domain protein 5 0.00911391
TMF1 TATA element modulatory factor 1 0.00894853
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00893038
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00891677
POTEF POTE ankyrin domain family, member F 0.00889317
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.00879649
ANO6 anoctamin 6 0.0087826
ANXA5 annexin A5 0.00873551
CEMIP cell migration inducing protein, hyaluronan binding 0.00869448
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.00869184
PDE10A phosphodiesterase 10A 0.00867298
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.00863888
ELOVL5 ELOVL fatty acid elongase 5 0.00862679

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.340318
COL1A1 collagen, type I, alpha 1 -0.217606
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.204302
IGFBP3 insulin-like growth factor binding protein 3 -0.162275
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.156675
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140448
IER3 immediate early response 3 -0.138758
TMSB10 thymosin beta 10 -0.129415
MT2A metallothionein 2A -0.121662
COL1A2 collagen, type I, alpha 2 -0.120725
NDRG1 N-myc downstream regulated 1 -0.116437
TGFBI transforming growth factor, beta-induced, 68kDa -0.0970205
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0916635
PTMA prothymosin, alpha -0.0869406
FTL ferritin, light polypeptide -0.0868039
RPS8 ribosomal protein S8 -0.0755224
RPL35A ribosomal protein L35a -0.0753495
RPS6 ribosomal protein S6 -0.0692862
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0680165
TPM4 tropomyosin 4 -0.0660448
CADM1 cell adhesion molecule 1 -0.0642933
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.062499
CAVIN1 caveolae associated protein 1 -0.0619242
HLA-B major histocompatibility complex, class I, B -0.0608098
TPT1 tumor protein, translationally-controlled 1 -0.0586001
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0585157
ACTG1 actin gamma 1 -0.0578684
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.056496
EIF1 eukaryotic translation initiation factor 1 -0.0562863
CANX calnexin -0.0517391
CALR calreticulin -0.0511337
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0486223
LMAN1 lectin, mannose-binding, 1 -0.046462
TMSB4X thymosin beta 4, X-linked -0.0460051
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.045897
MTDH metadherin -0.045262
S100A6 S100 calcium binding protein A6 -0.04391
S100A9 S100 calcium binding protein A9 -0.0436364
B2M beta-2-microglobulin -0.0428028
STC1 stanniocalcin 1 -0.0424865
ENO1 enolase 1, (alpha) -0.0424409
GNAS GNAS complex locus -0.0414958
NAMPT nicotinamide phosphoribosyltransferase -0.0409052
RRBP1 ribosome binding protein 1 -0.0408308
S100A10 S100 calcium binding protein A10 -0.0403827
UBC ubiquitin C -0.0394535
RPL8 ribosomal protein L8 -0.03902
RPL23 ribosomal protein L23 -0.0385909
KPNB1 karyopherin (importin) beta 1 -0.0385252
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0381971
CDH13 cadherin 13 -0.0378009
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0375369
F3 coagulation factor III (thromboplastin, tissue factor) -0.0374831
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0373996
CALU calumenin -0.0371027
RPL11 ribosomal protein L11 -0.0370967
VDAC1 voltage-dependent anion channel 1 -0.0365835
PGK1 phosphoglycerate kinase 1 -0.0360782
COL6A2 collagen, type VI, alpha 2 -0.0356504
RPLP1 ribosomal protein, large, P1 -0.0354647
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0347113
RPL19 ribosomal protein L19 -0.034397
RPL26 ribosomal protein L26 -0.0341146
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0340488
RPS24 ribosomal protein S24 -0.0338167
RPL12 ribosomal protein L12 -0.0326868
RPL34 ribosomal protein L34 -0.0323236
RPL28 ribosomal protein L28 -0.0313432
WSB1 WD repeat and SOCS box containing 1 -0.0311769
RPS19 ribosomal protein S19 -0.0311512
TM4SF1 transmembrane 4 L six family member 1 -0.030199
RPS20 ribosomal protein S20 -0.0300565
MT1X metallothionein 1X -0.0297442
RPLP2 ribosomal protein, large, P2 -0.0294714
RPL37A ribosomal protein L37a -0.0293001
ANXA2 annexin A2 -0.0285016
RPS27A ribosomal protein S27a -0.0284766
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0284658
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0282864
NAP1L1 nucleosome assembly protein 1-like 1 -0.0282175
RACK1 receptor for activated C kinase 1 -0.0280502
LOXL2 lysyl oxidase-like 2 -0.0279837
SEPTIN7 septin 7 -0.0279375
LOX lysyl oxidase -0.0277531
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0275093
ARL4C ADP-ribosylation factor-like 4C -0.0270992
RPLP0 ribosomal protein, large, P0 -0.0268828
RPL30 ribosomal protein L30 -0.0266517
RLF rearranged L-myc fusion -0.0266382
INHBA inhibin, beta A -0.0264933
ADM adrenomedullin -0.0264502
RPL37 ribosomal protein L37 -0.0262291
RPS3 ribosomal protein S3 -0.0260926
MAP4 microtubule-associated protein 4 -0.025932
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0258494
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0252059
LMNA lamin A/C -0.0251158
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0250616
SQSTM1 sequestosome 1 -0.0248597
RPS13 ribosomal protein S13 -0.0247068