| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.205696 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.175164 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0913741 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0845912 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0837355 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0804072 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0784751 |
| PLIN2 | perilipin 2 | 0.07831 |
| EHBP1 | EH domain binding protein 1 | 0.0730004 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0719837 |
| AHSG | alpha-2-HS-glycoprotein | 0.0686677 |
| ASPH | aspartate beta-hydroxylase | 0.0632432 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0617103 |
| KRT8 | keratin 8, type II | 0.0595347 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0592452 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0571038 |
| ENO1 | enolase 1, (alpha) | 0.0547928 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0516822 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0513446 |
| FRMD5 | FERM domain containing 5 | 0.0497107 |
| DST | dystonin | 0.046559 |
| STK17A | serine/threonine kinase 17a | 0.045619 |
| NPAS2 | neuronal PAS domain protein 2 | 0.045096 |
| FAT1 | FAT atypical cadherin 1 | 0.0442061 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0438194 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.043207 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0424504 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0424065 |
| AHR | aryl hydrocarbon receptor | 0.0397323 |
| TNS1 | tensin 1 | 0.0383452 |
| ATP10A | ATPase, class V, type 10A | 0.0382621 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0375492 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0363346 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0363101 |
| FMNL2 | formin-like 2 | 0.0357273 |
| VCL | vinculin | 0.0352061 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0345283 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0337738 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0333424 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0331603 |
| LDHA | lactate dehydrogenase A | 0.0329386 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0328647 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0328153 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0326491 |
| NHSL1 | NHS-like 1 | 0.0324293 |
| ATXN1 | ataxin 1 | 0.0322571 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0308318 |
| KIF1B | kinesin family member 1B | 0.029638 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.0295367 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0287108 |
| DSPP | dentin sialophosphoprotein | 0.0283553 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.027836 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.027829 |
| PEG3 | paternally expressed 3 | 0.0276656 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0276596 |
| RPL4 | ribosomal protein L4 | 0.0267044 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0264414 |
| TMEM123 | transmembrane protein 123 | 0.0264193 |
| TPM4 | tropomyosin 4 | 0.0260323 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0256917 |
| POTEF | POTE ankyrin domain family, member F | 0.0256504 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0253177 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0250501 |
| ARFGEF3 | ARFGEF family member 3 | 0.0242778 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0241023 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0238823 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0237632 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0237048 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0232896 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0228795 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0228664 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0224307 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.021925 |
| CP | ceruloplasmin (ferroxidase) | 0.0217772 |
| FILIP1L | filamin A interacting protein 1-like | 0.02163 |
| PRELID2 | PRELI domain containing 2 | 0.0215408 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0214059 |
| HMGA1 | high mobility group AT-hook 1 | 0.0212426 |
| NDRG1 | N-myc downstream regulated 1 | 0.0209759 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0207846 |
| CLIC1 | chloride intracellular channel 1 | 0.020737 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0206332 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0206066 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0203237 |
| KIZ | kizuna centrosomal protein | 0.0201809 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0200735 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0200342 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0198785 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0195072 |
| PHF3 | PHD finger protein 3 | 0.0192595 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0192466 |
| DISC1 | disrupted in schizophrenia 1 | 0.0190055 |
| RPL3 | ribosomal protein L3 | 0.0185205 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0181262 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0178972 |
| SBF2 | SET binding factor 2 | 0.0174588 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0173878 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.017104 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0170083 |
| GK | glycerol kinase | 0.0170047 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.156774 |
| APOB | apolipoprotein B | -0.129833 |
| C3 | complement component 3 | -0.123656 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.120287 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.107631 |
| MT2A | metallothionein 2A | -0.0960357 |
| RPS6 | ribosomal protein S6 | -0.0887877 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0883073 |
| IGF2 | insulin-like growth factor 2 | -0.0694201 |
| RPS12 | ribosomal protein S12 | -0.067789 |
| RPL11 | ribosomal protein L11 | -0.0627346 |
| RBM39 | RNA binding motif protein 39 | -0.0540064 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0517329 |
| RPS8 | ribosomal protein S8 | -0.0508086 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0507386 |
| RPL37A | ribosomal protein L37a | -0.0492281 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0481054 |
| RRBP1 | ribosome binding protein 1 | -0.0479753 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0465557 |
| RPS24 | ribosomal protein S24 | -0.0462609 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.045686 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0428811 |
| SVIL | supervillin | -0.0407349 |
| RPS2 | ribosomal protein S2 | -0.0403281 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0392025 |
| RPL26 | ribosomal protein L26 | -0.0384846 |
| RPLP1 | ribosomal protein, large, P1 | -0.0384742 |
| RPS19 | ribosomal protein S19 | -0.0384281 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.038351 |
| RPL9 | ribosomal protein L9 | -0.0376476 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0358396 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0346392 |
| RPLP2 | ribosomal protein, large, P2 | -0.0344042 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0342703 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0342686 |
| APOE | apolipoprotein E | -0.0342078 |
| RPL7 | ribosomal protein L7 | -0.0340631 |
| RPS3 | ribosomal protein S3 | -0.0336798 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0333178 |
| B2M | beta-2-microglobulin | -0.0333138 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.033251 |
| RPL19 | ribosomal protein L19 | -0.0332203 |
| RPL38 | ribosomal protein L38 | -0.033145 |
| PTMA | prothymosin, alpha | -0.0330371 |
| MRTFA | myocardin related transcription factor A | -0.0326176 |
| LCN2 | lipocalin 2 | -0.032296 |
| CFB | complement factor B | -0.0322883 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0322075 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0321303 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0318925 |
| FTL | ferritin, light polypeptide | -0.031021 |
| MED13L | mediator complex subunit 13-like | -0.0307618 |
| RPLP0 | ribosomal protein, large, P0 | -0.0306266 |
| TRIM26 | tripartite motif containing 26 | -0.0306018 |
| RPL12 | ribosomal protein L12 | -0.0305655 |
| JMJD1C | jumonji domain containing 1C | -0.0299895 |
| OLA1 | Obg-like ATPase 1 | -0.0299557 |
| GPC3 | glypican 3 | -0.0299113 |
| RPS27A | ribosomal protein S27a | -0.0292748 |
| RPL23 | ribosomal protein L23 | -0.028763 |
| RBM25 | RNA binding motif protein 25 | -0.0287484 |
| CPE | carboxypeptidase E | -0.0284693 |
| ZFR | zinc finger RNA binding protein | -0.0284272 |
| RPS13 | ribosomal protein S13 | -0.0283732 |
| UBXN4 | UBX domain protein 4 | -0.0283399 |
| SMAD3 | SMAD family member 3 | -0.0282274 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0279618 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0276903 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0275701 |
| PAPOLA | poly(A) polymerase alpha | -0.0273647 |
| SPAG9 | sperm associated antigen 9 | -0.0272075 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0271191 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0271043 |
| RPL36 | ribosomal protein L36 | -0.0269055 |
| RPL5 | ribosomal protein L5 | -0.0261728 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0258576 |
| NCKAP1 | NCK-associated protein 1 | -0.0256717 |
| RPL31 | ribosomal protein L31 | -0.0250349 |
| RPS21 | ribosomal protein S21 | -0.024709 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0244277 |
| RPL34 | ribosomal protein L34 | -0.0240099 |
| RPS16 | ribosomal protein S16 | -0.0239648 |
| RPS29 | ribosomal protein S29 | -0.0236667 |
| SELENOP | selenoprotein P | -0.0235113 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0234413 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0233518 |
| RPL32 | ribosomal protein L32 | -0.023312 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0232851 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0231315 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0230631 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0230359 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0229941 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0229621 |
| RPS5 | ribosomal protein S5 | -0.0229383 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.022857 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0225971 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0224919 |
| RPL30 | ribosomal protein L30 | -0.0224592 |
| RPL10A | ribosomal protein L10a | -0.0222208 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0220624 |
