| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.220485 |
| FLNB | filamin B, beta | 0.194992 |
| DPYD | dihydropyrimidine dehydrogenase | 0.155076 |
| DOCK5 | dedicator of cytokinesis 5 | 0.105822 |
| MYOF | myoferlin | 0.105589 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0992 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0946455 |
| ITGA6 | integrin, alpha 6 | 0.0915463 |
| PRELID2 | PRELI domain containing 2 | 0.0912086 |
| MTSS1 | metastasis suppressor 1 | 0.08367 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0816338 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0799626 |
| SULF1 | sulfatase 1 | 0.0780438 |
| MSN | moesin | 0.0765211 |
| RIN2 | Ras and Rab interactor 2 | 0.0764111 |
| BCL2L1 | BCL2-like 1 | 0.0734451 |
| MECOM | MDS1 and EVI1 complex locus | 0.0721961 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0720581 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0695178 |
| NRG1 | neuregulin 1 | 0.0675855 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0671813 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0663813 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0662131 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0659093 |
| ASPH | aspartate beta-hydroxylase | 0.0654195 |
| AHNAK | AHNAK nucleoprotein | 0.0644707 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0641365 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0624393 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0601917 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0597851 |
| SMYD3 | SET and MYND domain containing 3 | 0.0552948 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0540955 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0534449 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0532107 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0528012 |
| TGM2 | transglutaminase 2 | 0.0507879 |
| DST | dystonin | 0.0495789 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0489154 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0467633 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.046505 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.046256 |
| CAPRIN2 | caprin family member 2 | 0.0455911 |
| RAI14 | retinoic acid induced 14 | 0.0455851 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0450614 |
| FOXP1 | forkhead box P1 | 0.0450301 |
| EFNA5 | ephrin-A5 | 0.0447285 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0446386 |
| NEK7 | NIMA-related kinase 7 | 0.0439546 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0438978 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0436276 |
| PODXL | podocalyxin-like | 0.0424649 |
| RAD51B | RAD51 paralog B | 0.0419447 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0418936 |
| ENO1 | enolase 1, (alpha) | 0.0418473 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0417999 |
| RASAL2 | RAS protein activator like 2 | 0.0413116 |
| MEF2A | myocyte enhancer factor 2A | 0.0412986 |
| CDK6 | cyclin-dependent kinase 6 | 0.041207 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.040407 |
| AMOTL1 | angiomotin like 1 | 0.040286 |
| EZR | ezrin | 0.0395557 |
| BLCAP | bladder cancer associated protein | 0.0386817 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0384534 |
| UTRN | utrophin | 0.0382232 |
| EGFR | epidermal growth factor receptor | 0.0381946 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0379385 |
| MYO10 | myosin X | 0.0376599 |
| PLAT | plasminogen activator, tissue | 0.03745 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0369789 |
| MCL1 | myeloid cell leukemia 1 | 0.0364526 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0363147 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.036243 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0359826 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0354522 |
| OSMR | oncostatin M receptor | 0.0351861 |
| TNS3 | tensin 3 | 0.0351537 |
| PLEC | plectin | 0.0351134 |
| METTL15 | methyltransferase like 15 | 0.0344759 |
| LMO7 | LIM domain 7 | 0.0344004 |
| CLU | clusterin | 0.0343499 |
| EHF | ets homologous factor | 0.0342216 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0341123 |
| EXOC4 | exocyst complex component 4 | 0.0341015 |
| SLTM | SAFB-like, transcription modulator | 0.0340376 |
| TPM3 | tropomyosin 3 | 0.0338564 |
| EXOC6B | exocyst complex component 6B | 0.0336943 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.033401 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0333952 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0332283 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0328608 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0326826 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0324503 |
| FOXO1 | forkhead box O1 | 0.0320313 |
| HMGA2 | high mobility group AT-hook 2 | 0.0319825 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.031773 |
| EMP1 | epithelial membrane protein 1 | 0.0313957 |
| DOK5 | docking protein 5 | 0.0311225 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.030979 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0308432 |
| PTK2 | protein tyrosine kinase 2 | 0.030839 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0860559 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0825159 |
| B2M | beta-2-microglobulin | -0.0723893 |
| PTMA | prothymosin, alpha | -0.071028 |
| TMSB10 | thymosin beta 10 | -0.0660885 |
| RPS21 | ribosomal protein S21 | -0.0585278 |
| HLA-B | major histocompatibility complex, class I, B | -0.053224 |
| RPS6 | ribosomal protein S6 | -0.0469909 |
| S100A10 | S100 calcium binding protein A10 | -0.0468281 |
| MT2A | metallothionein 2A | -0.04594 |
| RPS24 | ribosomal protein S24 | -0.0457711 |
| RPLP1 | ribosomal protein, large, P1 | -0.0456276 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0451059 |
| RPLP2 | ribosomal protein, large, P2 | -0.0442313 |
| GOLGA4 | golgin A4 | -0.0418903 |
| TMSB4X | thymosin beta 4, X-linked | -0.0414292 |
| RPS13 | ribosomal protein S13 | -0.0394867 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0375834 |
| SQSTM1 | sequestosome 1 | -0.0375264 |
| RPS8 | ribosomal protein S8 | -0.0369085 |
| RPL34 | ribosomal protein L34 | -0.0360506 |
| MORF4L2 | mortality factor 4 like 2 | -0.0359668 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0357505 |
| RPL35A | ribosomal protein L35a | -0.0353161 |
| FTL | ferritin, light polypeptide | -0.0353055 |
| RPL11 | ribosomal protein L11 | -0.035105 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.034869 |
| SPAG9 | sperm associated antigen 9 | -0.0348575 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0341165 |
| KRT17 | keratin 17, type I | -0.0340967 |
| RPS25 | ribosomal protein S25 | -0.0326121 |
| SQLE | squalene epoxidase | -0.0319183 |
| RPS19 | ribosomal protein S19 | -0.0318247 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0315874 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.031577 |
| S100A6 | S100 calcium binding protein A6 | -0.03062 |
| GNAS | GNAS complex locus | -0.0298927 |
| MT1X | metallothionein 1X | -0.0296912 |
| RPL37 | ribosomal protein L37 | -0.029502 |
| STC1 | stanniocalcin 1 | -0.0282595 |
| RPL23 | ribosomal protein L23 | -0.028011 |
| RPS14 | ribosomal protein S14 | -0.0276239 |
| RPL8 | ribosomal protein L8 | -0.0270001 |
| UBC | ubiquitin C | -0.0268314 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0262558 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0260555 |
| RPL31 | ribosomal protein L31 | -0.0256372 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0255155 |
| RPL27A | ribosomal protein L27a | -0.0253707 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0252841 |
| RPS27A | ribosomal protein S27a | -0.025149 |
| RPL12 | ribosomal protein L12 | -0.024836 |
| RPS23 | ribosomal protein S23 | -0.024436 |
| RPS12 | ribosomal protein S12 | -0.0242062 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0234009 |
| RPL19 | ribosomal protein L19 | -0.0231367 |
| HM13 | histocompatibility (minor) 13 | -0.0230789 |
| LMNA | lamin A/C | -0.0229561 |
| CSTB | cystatin B (stefin B) | -0.022882 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0224738 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0224486 |
| NAV2 | neuron navigator 2 | -0.0221699 |
| RPLP0 | ribosomal protein, large, P0 | -0.0221476 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0219283 |
| RPL37A | ribosomal protein L37a | -0.0219067 |
| RPS3 | ribosomal protein S3 | -0.0212945 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0210882 |
| RPL36A | ribosomal protein L36a | -0.0210128 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0208193 |
| OGA | O-GlcNAcase | -0.0206654 |
| S100A11 | S100 calcium binding protein A11 | -0.0199472 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0199065 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0197628 |
| CANX | calnexin | -0.0197593 |
| KLF6 | Kruppel-like factor 6 | -0.0197303 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0196137 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0195337 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0195041 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0194859 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0193296 |
| S100A4 | S100 calcium binding protein A4 | -0.0192976 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0191667 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0190818 |
| H1-0 | H1.0 linker histone | -0.0189947 |
| RPL30 | ribosomal protein L30 | -0.0188096 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0184727 |
| RPS16 | ribosomal protein S16 | -0.0183584 |
| RPL28 | ribosomal protein L28 | -0.0182561 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0181561 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0181041 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0180097 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0178969 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0178377 |
| RPS5 | ribosomal protein S5 | -0.0178329 |
| ARF1 | ADP-ribosylation factor 1 | -0.0176643 |
| RPL39 | ribosomal protein L39 | -0.0175712 |
| HLA-A | major histocompatibility complex, class I, A | -0.0174991 |
| RPL26 | ribosomal protein L26 | -0.017423 |
| RPS4X | ribosomal protein S4, X-linked | -0.017409 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0173161 |
