| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.199426 |
| FLNB | filamin B, beta | 0.128672 |
| FAT1 | FAT atypical cadherin 1 | 0.11712 |
| EZR | ezrin | 0.114481 |
| NPSR1 | neuropeptide S receptor 1 | 0.100607 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0974759 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0924421 |
| FAM13A | family with sequence similarity 13, member A | 0.0900634 |
| KRT8 | keratin 8, type II | 0.0889613 |
| TXNIP | thioredoxin interacting protein | 0.0874553 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0842968 |
| ITGA6 | integrin, alpha 6 | 0.0830141 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0742566 |
| ANXA2 | annexin A2 | 0.073656 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0727386 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0685981 |
| DSPP | dentin sialophosphoprotein | 0.0684602 |
| CCNY | cyclin Y | 0.0664635 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0659855 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0619285 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0606404 |
| ASPH | aspartate beta-hydroxylase | 0.0603778 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0571298 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0569889 |
| PRELID2 | PRELI domain containing 2 | 0.0565791 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0533545 |
| CALB1 | calbindin 1, 28kDa | 0.0505384 |
| POTEF | POTE ankyrin domain family, member F | 0.0491782 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0491604 |
| RREB1 | ras responsive element binding protein 1 | 0.0485822 |
| VEGFA | vascular endothelial growth factor A | 0.0482135 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0476521 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0475639 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.047301 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0465902 |
| RNF217 | ring finger protein 217 | 0.046383 |
| ZNF292 | zinc finger protein 292 | 0.0461057 |
| TPM4 | tropomyosin 4 | 0.0455622 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0439625 |
| ENO1 | enolase 1, (alpha) | 0.0422432 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0397896 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0394294 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0394065 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0392039 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0388035 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0386235 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0378348 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0372014 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0369915 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0367102 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.03605 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0358322 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0358176 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0351173 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348956 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0342011 |
| EMP1 | epithelial membrane protein 1 | 0.0337658 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0334852 |
| ITGB4 | integrin, beta 4 | 0.0327185 |
| CENPF | centromere protein F, 350/400kDa | 0.0327152 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0325276 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0322952 |
| MCL1 | myeloid cell leukemia 1 | 0.0322165 |
| PGK1 | phosphoglycerate kinase 1 | 0.0321014 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0320835 |
| PRSS3 | protease, serine, 3 | 0.0317482 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0314139 |
| DIAPH2 | diaphanous-related formin 2 | 0.031104 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0309295 |
| LDHA | lactate dehydrogenase A | 0.0308061 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0305942 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0303008 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0300003 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0299646 |
| LAMC2 | laminin, gamma 2 | 0.0297697 |
| MXD1 | MAX dimerization protein 1 | 0.0295641 |
| FNBP1L | formin binding protein 1-like | 0.028922 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0288891 |
| MUC17 | mucin 17, cell surface associated | 0.028773 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0285584 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0283343 |
| ADD3 | adducin 3 (gamma) | 0.0283315 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0282841 |
| EHF | ets homologous factor | 0.0282 |
| MYO5B | myosin VB | 0.0280872 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0279012 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0276603 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0275613 |
| FOSL1 | FOS-like antigen 1 | 0.0274624 |
| LMO7 | LIM domain 7 | 0.0274235 |
| AHNAK | AHNAK nucleoprotein | 0.0271077 |
| CDCP1 | CUB domain containing protein 1 | 0.0269068 |
| RCOR1 | REST corepressor 1 | 0.0263884 |
| DENND1A | DENN/MADD domain containing 1A | 0.0259144 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0259034 |
| SLK | STE20-like kinase | 0.0258864 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0256207 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0255289 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0254781 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0253432 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.146444 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0848672 |
| PTMA | prothymosin, alpha | -0.0821335 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0739801 |
| GOLGA4 | golgin A4 | -0.0731011 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0646411 |
| RPS6 | ribosomal protein S6 | -0.0584321 |
| RPLP1 | ribosomal protein, large, P1 | -0.0532759 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0499013 |
| CANX | calnexin | -0.048512 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0484454 |
| GPHN | gephyrin | -0.0476551 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0476406 |
| RPL26 | ribosomal protein L26 | -0.0473201 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0471724 |
| HDLBP | high density lipoprotein binding protein | -0.0446856 |
| RPL12 | ribosomal protein L12 | -0.0443967 |
| TMSB10 | thymosin beta 10 | -0.0441636 |
| GDF15 | growth differentiation factor 15 | -0.0436472 |
| RRBP1 | ribosome binding protein 1 | -0.042717 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0419061 |
| RPS24 | ribosomal protein S24 | -0.0414275 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.041153 |
| RPLP2 | ribosomal protein, large, P2 | -0.0404966 |
| S100P | S100 calcium binding protein P | -0.0398794 |
| RPL34 | ribosomal protein L34 | -0.0388285 |
| RPLP0 | ribosomal protein, large, P0 | -0.0380001 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0377902 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0367399 |
| RPL5 | ribosomal protein L5 | -0.036626 |
| AREG | amphiregulin | -0.0364352 |
| COG5 | component of oligomeric golgi complex 5 | -0.0340704 |
| RPL35A | ribosomal protein L35a | -0.0333046 |
| RPS19 | ribosomal protein S19 | -0.0324397 |
| FTL | ferritin, light polypeptide | -0.0319986 |
| RBM25 | RNA binding motif protein 25 | -0.0317502 |
| ARF1 | ADP-ribosylation factor 1 | -0.0311841 |
| RPL11 | ribosomal protein L11 | -0.0309565 |
| RPS3 | ribosomal protein S3 | -0.0308492 |
| RBM39 | RNA binding motif protein 39 | -0.0305523 |
| RNF43 | ring finger protein 43 | -0.030456 |
| NFIA | nuclear factor I/A | -0.0302538 |
| ONECUT3 | one cut homeobox 3 | -0.0301847 |
| RPS8 | ribosomal protein S8 | -0.0301714 |
| RACK1 | receptor for activated C kinase 1 | -0.0300565 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0298718 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0296365 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0293173 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.028816 |
| RPL32 | ribosomal protein L32 | -0.0287166 |
| RPL23 | ribosomal protein L23 | -0.0281706 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0279682 |
| RPL19 | ribosomal protein L19 | -0.0278173 |
| RPL27A | ribosomal protein L27a | -0.0276115 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.027061 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0269694 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0269547 |
| ETNK1 | ethanolamine kinase 1 | -0.0265304 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0263697 |
| RPL36 | ribosomal protein L36 | -0.0258456 |
| RPS12 | ribosomal protein S12 | -0.0257445 |
| RPL13A | ribosomal protein L13a | -0.02574 |
| RPS27A | ribosomal protein S27a | -0.0256984 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0252393 |
| RAB10 | RAB10, member RAS oncogene family | -0.0252319 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0247341 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0247206 |
| EPCAM | epithelial cell adhesion molecule | -0.0245806 |
| RPS29 | ribosomal protein S29 | -0.0244961 |
| AGR2 | anterior gradient 2 | -0.0243096 |
| RPL31 | ribosomal protein L31 | -0.0241284 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0239825 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0238352 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0238304 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0234761 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0234162 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0230431 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0230318 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0228534 |
| HDAC2 | histone deacetylase 2 | -0.0227942 |
| RPL9 | ribosomal protein L9 | -0.0227918 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0227866 |
| CCND1 | cyclin D1 | -0.0227483 |
| POF1B | premature ovarian failure, 1B | -0.0226393 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0224726 |
| PHF3 | PHD finger protein 3 | -0.0224546 |
| RPL30 | ribosomal protein L30 | -0.0224361 |
| RPL7 | ribosomal protein L7 | -0.0223658 |
| RPL18 | ribosomal protein L18 | -0.0221094 |
| CFAP73 | cilia and flagella associated protein 73 | -0.0220886 |
| RPS21 | ribosomal protein S21 | -0.0219827 |
| EXT1 | exostosin glycosyltransferase 1 | -0.021773 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0216245 |
| WDR43 | WD repeat domain 43 | -0.021599 |
| PIGR | polymeric immunoglobulin receptor | -0.0214273 |
| RPS13 | ribosomal protein S13 | -0.0213676 |
| RPL8 | ribosomal protein L8 | -0.0213413 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0211497 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0210628 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0209832 |
