Tirabrutinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.19116
DST dystonin 0.148166
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.108002
RUNX1 runt-related transcription factor 1 0.0884339
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0844197
EHBP1 EH domain binding protein 1 0.0694486
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0655262
CENPF centromere protein F, 350/400kDa 0.064042
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0631598
WWTR1 WW domain containing transcription regulator 1 0.0570008
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0556044
TSC22D1 TSC22 domain family, member 1 0.0548276
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0536953
MACF1 microtubule-actin crosslinking factor 1 0.0530808
TXNRD1 thioredoxin reductase 1 0.052698
ERRFI1 ERBB receptor feedback inhibitor 1 0.0520551
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0509396
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0507466
DPYD dihydropyrimidine dehydrogenase 0.0502384
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0498604
BCAR3 breast cancer anti-estrogen resistance 3 0.0477117
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0476303
CAPRIN2 caprin family member 2 0.0461237
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0459712
DOCK11 dedicator of cytokinesis 11 0.0404865
MBNL2 muscleblind-like splicing regulator 2 0.039291
BIRC2 baculoviral IAP repeat containing 2 0.0389714
POTEF POTE ankyrin domain family, member F 0.0385966
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0380432
KTN1 kinectin 1 (kinesin receptor) 0.0376203
CD44 CD44 molecule (Indian blood group) 0.0369027
PRELID2 PRELI domain containing 2 0.0358775
RAD51B RAD51 paralog B 0.0357153
EXOC4 exocyst complex component 4 0.0350219
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0341902
MYOF myoferlin 0.0340573
ADGRG6 adhesion G protein-coupled receptor G6 0.0340145
SDCCAG8 serologically defined colon cancer antigen 8 0.0332319
F2R coagulation factor II (thrombin) receptor 0.0324161
PODXL podocalyxin-like 0.0323505
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0323341
VCL vinculin 0.0320875
VEGFC vascular endothelial growth factor C 0.0314442
SMYD3 SET and MYND domain containing 3 0.0294644
PLK2 polo-like kinase 2 0.0287759
SLC38A2 solute carrier family 38, member 2 0.0283995
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0277077
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0268749
MBD5 methyl-CpG binding domain protein 5 0.0268137
MKI67 marker of proliferation Ki-67 0.0266991
NPAS2 neuronal PAS domain protein 2 0.0266745
CDK6 cyclin-dependent kinase 6 0.0262455
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0260891
MYO10 myosin X 0.0260141
CFAP299 cilia and flagella associated protein 299 0.0258617
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0258308
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.025675
TAS2R14 taste receptor, type 2, member 14 0.0249527
BPTF bromodomain PHD finger transcription factor 0.0248045
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0242427
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0240399
LOXL2 lysyl oxidase-like 2 0.0237881
ZBTB38 zinc finger and BTB domain containing 38 0.023714
TBC1D5 TBC1 domain family, member 5 0.0236515
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0233206
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0231954
GCLM glutamate-cysteine ligase, modifier subunit 0.0226802
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0224936
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0222386
BABAM2 BRISC and BRCA1 A complex member 2 0.0219883
RTTN rotatin 0.0219057
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0218899
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0214647
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0214511
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0214173
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.021228
ANTXR2 anthrax toxin receptor 2 0.0210813
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0209739
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0207282
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0206503
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0205184
SLK STE20-like kinase 0.0203346
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0203317
KDM4C lysine (K)-specific demethylase 4C 0.0198822
AKAP9 A kinase (PRKA) anchor protein 9 0.0197788
YEATS2 YEATS domain containing 2 0.0197591
RABGAP1L RAB GTPase activating protein 1-like 0.019638
NCEH1 neutral cholesterol ester hydrolase 1 0.0196215
FNIP1 folliculin interacting protein 1 0.0192709
PYGB phosphorylase, glycogen; brain 0.0192429
TRIO trio Rho guanine nucleotide exchange factor 0.0191475
TRERF1 transcriptional regulating factor 1 0.0190864
LPP LIM domain containing preferred translocation partner in lipoma 0.0189508
STK17A serine/threonine kinase 17a 0.0187962
THSD4 thrombospondin, type I, domain containing 4 0.018626
ATG10 autophagy related 10 0.0185491
TRIP12 thyroid hormone receptor interactor 12 0.0182326
RASAL2 RAS protein activator like 2 0.0182047
ARHGAP5 Rho GTPase activating protein 5 0.0177201
ARB2A ARB2 cotranscriptional regulator A 0.0174907

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.244438
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173527
TMSB10 thymosin beta 10 -0.153214
MT2A metallothionein 2A -0.134852
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111328
PTMA prothymosin, alpha -0.102539
HLA-B major histocompatibility complex, class I, B -0.0925698
TPT1 tumor protein, translationally-controlled 1 -0.0810069
UBC ubiquitin C -0.0806811
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0793354
FTL ferritin, light polypeptide -0.0690005
TMSB4X thymosin beta 4, X-linked -0.0679523
RPL35A ribosomal protein L35a -0.0606739
WSB1 WD repeat and SOCS box containing 1 -0.0565865
RPS27A ribosomal protein S27a -0.0557072
MT1X metallothionein 1X -0.0555474
RPS6 ribosomal protein S6 -0.0489954
RPL31 ribosomal protein L31 -0.0477814
RPL36 ribosomal protein L36 -0.0432862
RPL26 ribosomal protein L26 -0.0423013
RPLP2 ribosomal protein, large, P2 -0.0421326
RPL12 ribosomal protein L12 -0.0411942
RPS8 ribosomal protein S8 -0.0397252
RPL37A ribosomal protein L37a -0.0396035
RPL37 ribosomal protein L37 -0.0394798
RAB7A RAB7A, member RAS oncogene family -0.0394309
RPLP1 ribosomal protein, large, P1 -0.0393348
RPL23 ribosomal protein L23 -0.0393179
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0392284
RPL36A ribosomal protein L36a -0.0391291
RPS3 ribosomal protein S3 -0.0388184
RPS19 ribosomal protein S19 -0.0382478
RPS12 ribosomal protein S12 -0.0379484
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0378655
SPAG9 sperm associated antigen 9 -0.0360182
KDM3A lysine (K)-specific demethylase 3A -0.0340328
MT1E metallothionein 1E -0.0339135
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0331656
RPL19 ribosomal protein L19 -0.0329956
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0328779
CANX calnexin -0.032246
RPL28 ribosomal protein L28 -0.0309022
RPS24 ribosomal protein S24 -0.0306875
EIF1 eukaryotic translation initiation factor 1 -0.0302208
S100A6 S100 calcium binding protein A6 -0.0295391
TP63 tumor protein p63 -0.0289783
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0282209
RPS23 ribosomal protein S23 -0.0277576
B2M beta-2-microglobulin -0.0272459
ADAM17 ADAM metallopeptidase domain 17 -0.0270279
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0270034
CALR calreticulin -0.0263564
OGA O-GlcNAcase -0.0261646
FTH1 ferritin, heavy polypeptide 1 -0.0260476
RPS25 ribosomal protein S25 -0.0257023
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0256021
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0250045
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0246351
HMGA1 high mobility group AT-hook 1 -0.0243297
NAP1L1 nucleosome assembly protein 1-like 1 -0.02429
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0241587
RPL27A ribosomal protein L27a -0.0239945
RPS29 ribosomal protein S29 -0.0237739
HLA-E major histocompatibility complex, class I, E -0.0235375
RPLP0 ribosomal protein, large, P0 -0.0234153
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.023286
GNAS GNAS complex locus -0.0229256
GARS1 glycyl-tRNA synthetase 1 -0.0224992
NPEPPS aminopeptidase puromycin sensitive -0.0223513
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0222483
RPS27 ribosomal protein S27 -0.0218695
RPL35 ribosomal protein L35 -0.0215587
IFIH1 interferon induced with helicase C domain 1 -0.021472
APP amyloid beta (A4) precursor protein -0.0213277
RPL38 ribosomal protein L38 -0.0211311
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0208607
RPL9 ribosomal protein L9 -0.020719
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0205187
RPL5 ribosomal protein L5 -0.0204872
SLC38A1 solute carrier family 38, member 1 -0.0203187
KCMF1 potassium channel modulatory factor 1 -0.0202432
RPL7A ribosomal protein L7a -0.0202349
RPL34 ribosomal protein L34 -0.020162
PRRC2C proline-rich coiled-coil 2C -0.0200093
RPS13 ribosomal protein S13 -0.0197768
LOC112694756 uncharaterized LOC112694756 -0.0197426
RPS10 ribosomal protein S10 -0.019678
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0196236
RPS14 ribosomal protein S14 -0.0192305
KLF6 Kruppel-like factor 6 -0.0190673
GLG1 golgi glycoprotein 1 -0.0188708
S100A10 S100 calcium binding protein A10 -0.0188707
RPS5 ribosomal protein S5 -0.0186907
RPL8 ribosomal protein L8 -0.0184497
RAB1A RAB1A, member RAS oncogene family -0.0184002
PGK1 phosphoglycerate kinase 1 -0.0183116
SQSTM1 sequestosome 1 -0.0179648
RPS28 ribosomal protein S28 -0.0178625
PDIA4 protein disulfide isomerase family A, member 4 -0.0178341
RPL11 ribosomal protein L11 -0.0177492