Tirabrutinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.368422
THSD4 thrombospondin, type I, domain containing 4 0.14352
ASPH aspartate beta-hydroxylase 0.125771
TXNRD1 thioredoxin reductase 1 0.11821
PTPRM protein tyrosine phosphatase, receptor type, M 0.0927695
GRAMD1B GRAM domain containing 1B 0.0842334
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0824703
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0796081
EFNA5 ephrin-A5 0.0764312
LAMA4 laminin, alpha 4 0.0727899
LAMC2 laminin, gamma 2 0.0720813
OSMR oncostatin M receptor 0.0680899
SLTM SAFB-like, transcription modulator 0.0654119
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0650259
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0616179
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0613084
DOCK5 dedicator of cytokinesis 5 0.0579007
LMO7 LIM domain 7 0.0574868
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.054747
PDE4D phosphodiesterase 4D, cAMP-specific 0.0523309
TBC1D22A TBC1 domain family, member 22A 0.0520999
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0517171
CXCL8 chemokine (C-X-C motif) ligand 8 0.0515787
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0508639
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.046926
LGALS12 lectin, galactoside-binding, soluble, 12 0.0463105
MAML3 mastermind-like 3 (Drosophila) 0.0433831
MCL1 myeloid cell leukemia 1 0.0426212
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0413686
LPP LIM domain containing preferred translocation partner in lipoma 0.0409314
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0404647
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0401245
ERRFI1 ERBB receptor feedback inhibitor 1 0.0400432
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0396839
FNDC3B fibronectin type III domain containing 3B 0.0395028
BCAR3 breast cancer anti-estrogen resistance 3 0.0393871
CES1 carboxylesterase 1 0.0392106
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0390052
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0385064
SMAD3 SMAD family member 3 0.0373694
PATJ PATJ crumbs cell polarity complex component 0.0368512
LDHA lactate dehydrogenase A 0.0364405
CEMIP cell migration inducing protein, hyaluronan binding 0.0357365
SCEL sciellin 0.0352225
CAV1 caveolin 1, caveolae protein, 22kDa 0.0349848
RNF213 ring finger protein 213 0.0343499
SAMD4A sterile alpha motif domain containing 4A 0.0336734
SMYD3 SET and MYND domain containing 3 0.0330524
TRIP12 thyroid hormone receptor interactor 12 0.0329644
PYGL phosphorylase, glycogen, liver 0.0315541
ANXA2 annexin A2 0.0315244
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0314514
DOCK1 dedicator of cytokinesis 1 0.0312064
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0302257
NPAS2 neuronal PAS domain protein 2 0.0299955
STC1 stanniocalcin 1 0.0299158
GCLC glutamate-cysteine ligase, catalytic subunit 0.0293367
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0288904
AKAP13 A kinase (PRKA) anchor protein 13 0.0279229
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0277146
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0277083
ATP11A ATPase, class VI, type 11A 0.0275662
DSPP dentin sialophosphoprotein 0.027546
FOXP1 forkhead box P1 0.026738
LRP1B low density lipoprotein receptor-related protein 1B 0.0264332
EPAS1 endothelial PAS domain protein 1 0.0261727
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0259912
RIN2 Ras and Rab interactor 2 0.0255943
MYOF myoferlin 0.0255655
MCTP1 multiple C2 domains, transmembrane 1 0.0255326
PKM pyruvate kinase, muscle 0.0253956
SUMF1 sulfatase modifying factor 1 0.0251684
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0249925
MYO1E myosin IE 0.0246628
LAMB3 laminin, beta 3 0.0246461
TBC1D5 TBC1 domain family, member 5 0.0242868
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0242315
NRIP1 nuclear receptor interacting protein 1 0.0241646
SLC38A2 solute carrier family 38, member 2 0.0241264
RAB27B RAB27B, member RAS oncogene family 0.0240518
AHNAK AHNAK nucleoprotein 0.0239118
VEGFC vascular endothelial growth factor C 0.0238989
PM20D1 peptidase M20 domain containing 1 0.0238363
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0238112
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0237817
VMP1 vacuole membrane protein 1 0.0234446
ZMYND8 zinc finger, MYND-type containing 8 0.0234148
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0234108
PDLIM5 PDZ and LIM domain 5 0.0232293
IGF1R insulin-like growth factor 1 receptor 0.0232178
IGFBP5 insulin-like growth factor binding protein 5 0.0228782
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0227229
TMEM45B transmembrane protein 45B 0.0226881
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0223167
MACF1 microtubule-actin crosslinking factor 1 0.0221278
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0220329
EXT1 exostosin glycosyltransferase 1 0.0218294
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.021783
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0216686
AKAP12 A kinase (PRKA) anchor protein 12 0.02144

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105518
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0523195
MT2A metallothionein 2A -0.0409335
TPT1 tumor protein, translationally-controlled 1 -0.040628
TMEM165 transmembrane protein 165 -0.0396145
TMSB10 thymosin beta 10 -0.0356551
FTL ferritin, light polypeptide -0.0345495
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.033682
RPLP1 ribosomal protein, large, P1 -0.0292978
SEC61G Sec61 gamma subunit -0.0275822
CAMTA1 calmodulin binding transcription activator 1 -0.0254755
RPL35A ribosomal protein L35a -0.0253859
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0245789
WDR45B WD repeat domain 45B -0.0232243
SPAG9 sperm associated antigen 9 -0.0227602
RPS25 ribosomal protein S25 -0.0222302
RPS3 ribosomal protein S3 -0.022213
P4HB prolyl 4-hydroxylase, beta polypeptide -0.022178
RPLP0 ribosomal protein, large, P0 -0.0207022
RPS24 ribosomal protein S24 -0.0206905
SRP54 signal recognition particle 54kDa -0.0197748
RPL37A ribosomal protein L37a -0.0196589
HYOU1 hypoxia up-regulated 1 -0.0194267
KCMF1 potassium channel modulatory factor 1 -0.0189057
RAP1B RAP1B, member of RAS oncogene family -0.0187538
KMT2E lysine (K)-specific methyltransferase 2E -0.0186594
ADAM17 ADAM metallopeptidase domain 17 -0.018553
WASF2 WAS protein family, member 2 -0.0183974
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0178547
RNMT RNA (guanine-7-) methyltransferase -0.0178165
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0176143
RAB1A RAB1A, member RAS oncogene family -0.0174859
PTMA prothymosin, alpha -0.017434
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.01724
RPL34 ribosomal protein L34 -0.0170978
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0169906
RPS6 ribosomal protein S6 -0.016962
SEPTIN2 septin 2 -0.0168753
PDE8A phosphodiesterase 8A -0.016508
RPL31 ribosomal protein L31 -0.0161625
RPS23 ribosomal protein S23 -0.0160279
H1-0 H1.0 linker histone -0.015873
EIF1 eukaryotic translation initiation factor 1 -0.0157395
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0155974
RAB7A RAB7A, member RAS oncogene family -0.0154034
BTG1 B-cell translocation gene 1, anti-proliferative -0.015283
OGA O-GlcNAcase -0.0143747
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.01376
RPLP2 ribosomal protein, large, P2 -0.0136756
RPS27A ribosomal protein S27a -0.0136363
HILPDA hypoxia inducible lipid droplet-associated -0.0133641
NGLY1 N-glycanase 1 -0.0132369
SEC31A SEC31 homolog A (S. cerevisiae) -0.0131667
RPL8 ribosomal protein L8 -0.0131125
KDM3A lysine (K)-specific demethylase 3A -0.0129615
RPL11 ribosomal protein L11 -0.0128985
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0128293
ANKRD37 ankyrin repeat domain 37 -0.012801
RPL23 ribosomal protein L23 -0.0126692
RPS19 ribosomal protein S19 -0.012584
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0124678
IER3 immediate early response 3 -0.0124352
RPL12 ribosomal protein L12 -0.0123294
RUNX1 runt-related transcription factor 1 -0.0122849
ARRDC3 arrestin domain containing 3 -0.0120852
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0119945
MT1X metallothionein 1X -0.0119703
RPL37 ribosomal protein L37 -0.0116596
SREBF2 sterol regulatory element binding transcription factor 2 -0.011643
RPL30 ribosomal protein L30 -0.0116031
NUP58 nucleoporin 58 -0.0113995
SETD5 SET domain containing 5 -0.0112175
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0110184
CANX calnexin -0.0110109
NPTN neuroplastin -0.0109857
HELZ helicase with zinc finger -0.0109836
RPS8 ribosomal protein S8 -0.0109277
RNF145 ring finger protein 145 -0.0108841
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0106581
RPS13 ribosomal protein S13 -0.0104421
RPL7 ribosomal protein L7 -0.0104106
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -0.0103768
PNISR PNN-interacting serine/arginine-rich protein -0.0103757
GLS2 glutaminase 2 (liver, mitochondrial) -0.0103673
WSB1 WD repeat and SOCS box containing 1 -0.0100977
RPL36 ribosomal protein L36 -0.0100716
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0100239
RPS29 ribosomal protein S29 -0.0100191
MATR3 matrin 3 -0.0099304
RPL19 ribosomal protein L19 -0.00992912
SUCO SUN domain containing ossification factor -0.00987611
RPS14 ribosomal protein S14 -0.00986866
CCNI cyclin I -0.00982744
GUK1 guanylate kinase 1 -0.00979227
RPS27 ribosomal protein S27 -0.00972284
RPS21 ribosomal protein S21 -0.00967585
JMJD1C jumonji domain containing 1C -0.00966288
UVRAG UV radiation resistance associated -0.00956273
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0094607
UBE2B ubiquitin-conjugating enzyme E2B -0.00929832