| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.151912 |
| NDRG1 | N-myc downstream regulated 1 | 0.110567 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.108202 |
| GRB10 | growth factor receptor-bound protein 10 | 0.106481 |
| NAV2 | neuron navigator 2 | 0.0774576 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0751036 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0736489 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0689424 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0670501 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0660563 |
| SMAD3 | SMAD family member 3 | 0.0652378 |
| SIK3 | SIK family kinase 3 | 0.0621996 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0611224 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.060901 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0582711 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0519148 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0516551 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.051498 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0510202 |
| FLNB | filamin B, beta | 0.0509827 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0489487 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.048773 |
| FAM107B | family with sequence similarity 107, member B | 0.0479114 |
| TGM2 | transglutaminase 2 | 0.0478646 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0460568 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0458389 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0455444 |
| FAM13A | family with sequence similarity 13, member A | 0.044995 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0438995 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0434001 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0433755 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.043182 |
| EFNA5 | ephrin-A5 | 0.042954 |
| MYO1B | myosin IB | 0.0417341 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0415334 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0413088 |
| PCBP2 | poly(rC) binding protein 2 | 0.0410369 |
| EGFR | epidermal growth factor receptor | 0.0408772 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0392363 |
| LOX | lysyl oxidase | 0.0389521 |
| ZNF292 | zinc finger protein 292 | 0.0383655 |
| COPA | coatomer protein complex, subunit alpha | 0.0355465 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0351974 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0351869 |
| CA12 | carbonic anhydrase XII | 0.0351225 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0347263 |
| RUNX1 | runt-related transcription factor 1 | 0.0347175 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0345791 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0340747 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.03381 |
| ATP13A3 | ATPase type 13A3 | 0.0334552 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0328592 |
| MCL1 | myeloid cell leukemia 1 | 0.0325731 |
| RNF24 | ring finger protein 24 | 0.0324541 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.03242 |
| JMJD1C | jumonji domain containing 1C | 0.0322164 |
| GOLGA4 | golgin A4 | 0.0317304 |
| SETD5 | SET domain containing 5 | 0.0317056 |
| RAD51B | RAD51 paralog B | 0.0315444 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0314199 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.031131 |
| USP34 | ubiquitin specific peptidase 34 | 0.0310325 |
| POTEF | POTE ankyrin domain family, member F | 0.0307439 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0303743 |
| RARB | retinoic acid receptor, beta | 0.0302382 |
| FOXO3 | forkhead box O3 | 0.0301605 |
| VMP1 | vacuole membrane protein 1 | 0.0301393 |
| SLTM | SAFB-like, transcription modulator | 0.0299949 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0299871 |
| HELZ | helicase with zinc finger | 0.0299829 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0297946 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0296339 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0293811 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0292215 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 0.0288552 |
| SPAG9 | sperm associated antigen 9 | 0.0286827 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0285516 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0285178 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0283961 |
| SEC24A | SEC24 family member A | 0.0283071 |
| OPTN | optineurin | 0.0281593 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0280232 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0278144 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0277418 |
| SRP54 | signal recognition particle 54kDa | 0.0277344 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0275114 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0272865 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0270677 |
| MYO10 | myosin X | 0.0267938 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0267605 |
| ANO6 | anoctamin 6 | 0.026645 |
| ATXN1 | ataxin 1 | 0.0265815 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0264487 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0260315 |
| CABIN1 | calcineurin binding protein 1 | 0.0257502 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0257335 |
| PHF21A | PHD finger protein 21A | 0.0255348 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0253578 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0253056 |
| VEGFA | vascular endothelial growth factor A | 0.0250731 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.255481 |
| TMSB10 | thymosin beta 10 | -0.1064 |
| PTMA | prothymosin, alpha | -0.100796 |
| FTL | ferritin, light polypeptide | -0.0968211 |
| VIM | vimentin | -0.0942421 |
| CDH13 | cadherin 13 | -0.086155 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0858404 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0851774 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0832974 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0776836 |
| NRG1 | neuregulin 1 | -0.0755463 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0744756 |
| IER3 | immediate early response 3 | -0.073772 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0702871 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0677083 |
| RPS24 | ribosomal protein S24 | -0.0648069 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0628877 |
| RPLP1 | ribosomal protein, large, P1 | -0.0618353 |
| RPL35A | ribosomal protein L35a | -0.0580888 |
| GLCCI1 | glucocorticoid induced 1 | -0.0530467 |
| RPL23 | ribosomal protein L23 | -0.0501507 |
| RPLP0 | ribosomal protein, large, P0 | -0.0500741 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.049284 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0479332 |
| RPL34 | ribosomal protein L34 | -0.0476651 |
| RPL32 | ribosomal protein L32 | -0.0475483 |
| RPS19 | ribosomal protein S19 | -0.0456666 |
| RPS8 | ribosomal protein S8 | -0.0452958 |
| CANX | calnexin | -0.0447038 |
| RPS6 | ribosomal protein S6 | -0.0439523 |
| RPS21 | ribosomal protein S21 | -0.0423979 |
| RPL11 | ribosomal protein L11 | -0.0404742 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0403738 |
| AHNAK | AHNAK nucleoprotein | -0.0394908 |
| RPLP2 | ribosomal protein, large, P2 | -0.0392361 |
| RPS11 | ribosomal protein S11 | -0.0379797 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0369707 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0365541 |
| RPL12 | ribosomal protein L12 | -0.0365304 |
| RPL19 | ribosomal protein L19 | -0.0363429 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0361992 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.035524 |
| S100A6 | S100 calcium binding protein A6 | -0.0353647 |
| RPL38 | ribosomal protein L38 | -0.0353333 |
| RPS25 | ribosomal protein S25 | -0.0351656 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0351318 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0351289 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.034377 |
| RPL37A | ribosomal protein L37a | -0.0340832 |
| MT2A | metallothionein 2A | -0.0339851 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0339489 |
| RPL37 | ribosomal protein L37 | -0.0331986 |
| STC1 | stanniocalcin 1 | -0.0328655 |
| TMSB4X | thymosin beta 4, X-linked | -0.0327815 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0319693 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.031052 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0309986 |
| RPS13 | ribosomal protein S13 | -0.0307713 |
| MTSS1 | metastasis suppressor 1 | -0.030718 |
| GNAS | GNAS complex locus | -0.0306608 |
| RPL36 | ribosomal protein L36 | -0.0305581 |
| RPL31 | ribosomal protein L31 | -0.0302588 |
| ACTG1 | actin gamma 1 | -0.0294579 |
| RPS16 | ribosomal protein S16 | -0.0292689 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0292483 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0291753 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0291123 |
| TXNRD1 | thioredoxin reductase 1 | -0.0287104 |
| RPS29 | ribosomal protein S29 | -0.0281892 |
| RPS23 | ribosomal protein S23 | -0.0275707 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0275566 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.027512 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0274023 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0271003 |
| H1-0 | H1.0 linker histone | -0.0268312 |
| RACK1 | receptor for activated C kinase 1 | -0.0266147 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0264155 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.026316 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0260643 |
| S100A10 | S100 calcium binding protein A10 | -0.0258293 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0252625 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0252106 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0250985 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0247473 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0244141 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0242473 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0242341 |
| TMEM263 | transmembrane protein 263 | -0.0241574 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0239779 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0238418 |
| RPL7A | ribosomal protein L7a | -0.0238402 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0236753 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0235704 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0231396 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0230967 |
| FAM162A | family with sequence similarity 162, member A | -0.0230435 |
| ZNF804A | zinc finger protein 804A | -0.0229822 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0229576 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0228769 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0228676 |
