| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DOCK4 | dedicator of cytokinesis 4 | 0.109904 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.108618 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0804416 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0668086 |
| MCL1 | myeloid cell leukemia 1 | 0.0634878 |
| FNDC3B | fibronectin type III domain containing 3B | 0.06301 |
| FMNL2 | formin-like 2 | 0.058207 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0565776 |
| CMIP | c-Maf inducing protein | 0.0542009 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0527421 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0518638 |
| POTEF | POTE ankyrin domain family, member F | 0.0503059 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0491426 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0461294 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0451523 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.042999 |
| FLNB | filamin B, beta | 0.040964 |
| PYGL | phosphorylase, glycogen, liver | 0.0405682 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0385982 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0385395 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0373302 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0358649 |
| COPA | coatomer protein complex, subunit alpha | 0.0344834 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0342973 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0341535 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0333271 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0324935 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0323644 |
| BRD2 | bromodomain containing 2 | 0.0320877 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0319315 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0315565 |
| NDRG1 | N-myc downstream regulated 1 | 0.0314021 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0309165 |
| SNX14 | sorting nexin 14 | 0.0309135 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0306865 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0306829 |
| GOLGA4 | golgin A4 | 0.0303449 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0302342 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.03016 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0300601 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0300413 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0297853 |
| PDE8A | phosphodiesterase 8A | 0.029327 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0291251 |
| RCOR1 | REST corepressor 1 | 0.0290503 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0290341 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0287162 |
| RAD51B | RAD51 paralog B | 0.028016 |
| HLA-B | major histocompatibility complex, class I, B | 0.0277061 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0277058 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0273726 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0273642 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0273336 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0270791 |
| ATXN1 | ataxin 1 | 0.0270138 |
| KIF5B | kinesin family member 5B | 0.0267804 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0267331 |
| CABIN1 | calcineurin binding protein 1 | 0.0262906 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0260999 |
| NUMB | numb homolog (Drosophila) | 0.0260078 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0256998 |
| GLG1 | golgi glycoprotein 1 | 0.0254326 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0253041 |
| FAM107B | family with sequence similarity 107, member B | 0.0252302 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0250968 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0250393 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0243915 |
| NEBL | nebulette | 0.0243239 |
| USP36 | ubiquitin specific peptidase 36 | 0.0240442 |
| PRKCE | protein kinase C, epsilon | 0.0235725 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0234362 |
| ITGB5 | integrin, beta 5 | 0.0234239 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0232965 |
| HLA-A | major histocompatibility complex, class I, A | 0.0228804 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0225765 |
| NHSL1 | NHS-like 1 | 0.0224949 |
| USP34 | ubiquitin specific peptidase 34 | 0.0221634 |
| NF1 | neurofibromin 1 | 0.0221427 |
| ACTN1 | actinin, alpha 1 | 0.0220922 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0220133 |
| SBF2 | SET binding factor 2 | 0.0217173 |
| CTBP2 | C-terminal binding protein 2 | 0.0216336 |
| LDHA | lactate dehydrogenase A | 0.0215938 |
| RPL3 | ribosomal protein L3 | 0.0215245 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0211354 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0210919 |
| JMJD1C | jumonji domain containing 1C | 0.0210394 |
| BMP6 | bone morphogenetic protein 6 | 0.0206901 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0206541 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0205095 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0204043 |
| EGFR | epidermal growth factor receptor | 0.0203498 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0202745 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0202652 |
| ATP11A | ATPase, class VI, type 11A | 0.0202648 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0202234 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0201229 |
| MYO1E | myosin IE | 0.0199676 |
| ANKRD11 | ankyrin repeat domain 11 | 0.019912 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0198319 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.185234 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.102099 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0983072 |
| TMSB10 | thymosin beta 10 | -0.083398 |
| TXNRD1 | thioredoxin reductase 1 | -0.0796872 |
| MT2A | metallothionein 2A | -0.0647668 |
| PTMA | prothymosin, alpha | -0.0645416 |
| RPL19 | ribosomal protein L19 | -0.0637042 |
| RPL23 | ribosomal protein L23 | -0.0631019 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0602648 |
| FGB | fibrinogen beta chain | -0.0548766 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0460722 |
| RPS21 | ribosomal protein S21 | -0.044032 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0405119 |
| USP3 | ubiquitin specific peptidase 3 | -0.0398219 |
| RPLP1 | ribosomal protein, large, P1 | -0.0387595 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0383859 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0381497 |
| S100A6 | S100 calcium binding protein A6 | -0.0378108 |
| DENND4A | DENN/MADD domain containing 4A | -0.0357479 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.035559 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0350795 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0346441 |
| RPLP0 | ribosomal protein, large, P0 | -0.0342404 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0326715 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0317612 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0317288 |
| RPS12 | ribosomal protein S12 | -0.0316337 |
| IER3 | immediate early response 3 | -0.0308828 |
| YBX1 | Y box binding protein 1 | -0.0307382 |
| RPS19 | ribosomal protein S19 | -0.0287903 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0280403 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0276734 |
| SRGN | serglycin | -0.0274368 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.02743 |
| YBX3 | Y box binding protein 3 | -0.0274051 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0273927 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0270048 |
| RPL8 | ribosomal protein L8 | -0.0267844 |
| RTN4 | reticulon 4 | -0.0265388 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0265259 |
| KLF6 | Kruppel-like factor 6 | -0.026479 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0264104 |
| SERF2 | small EDRK-rich factor 2 | -0.0262464 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0257951 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0255207 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0252461 |
| HMGB1 | high mobility group box 1 | -0.0251512 |
| PFN1 | profilin 1 | -0.0243705 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0241481 |
| OLA1 | Obg-like ATPase 1 | -0.0240495 |
| RPL34 | ribosomal protein L34 | -0.0240298 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0239664 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0235362 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0233237 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0230505 |
| FAM168A | family with sequence similarity 168, member A | -0.0229711 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0228243 |
| RPS8 | ribosomal protein S8 | -0.022783 |
| RPL18 | ribosomal protein L18 | -0.0226988 |
| CAVIN1 | caveolae associated protein 1 | -0.0226936 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0226664 |
| RPS5 | ribosomal protein S5 | -0.0225868 |
| TMEM123 | transmembrane protein 123 | -0.0220242 |
| JAK1 | Janus kinase 1 | -0.0217458 |
| WDR43 | WD repeat domain 43 | -0.0216181 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.021444 |
| RPL7 | ribosomal protein L7 | -0.0211993 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0208338 |
| RPL26 | ribosomal protein L26 | -0.0207482 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0206302 |
| S100A10 | S100 calcium binding protein A10 | -0.0200129 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0198906 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0198351 |
| THBS1 | thrombospondin 1 | -0.0196609 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0195098 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0191497 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0190266 |
| RPL36 | ribosomal protein L36 | -0.0189666 |
| HMGA1 | high mobility group AT-hook 1 | -0.0187142 |
| S100A9 | S100 calcium binding protein A9 | -0.0186155 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | -0.0184308 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0184037 |
| PFDN2 | prefoldin subunit 2 | -0.0183934 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0182613 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0181193 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0180957 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0178906 |
| RBM8A | RNA binding motif protein 8A | -0.0176496 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0175945 |
| RPS20 | ribosomal protein S20 | -0.0175291 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | -0.0174062 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0170368 |
| ILF2 | interleukin enhancer binding factor 2 | -0.016953 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0167982 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0167137 |
| RPS27A | ribosomal protein S27a | -0.0166962 |
| RPL12 | ribosomal protein L12 | -0.0166566 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0166522 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0166135 |
