| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.153651 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.149609 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.126156 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0854844 |
| DICER1 | dicer 1, ribonuclease type III | 0.0752336 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0646348 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0573737 |
| VCL | vinculin | 0.0573729 |
| SDC4 | syndecan 4 | 0.0565944 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0554731 |
| XDH | xanthine dehydrogenase | 0.053609 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0531707 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0517856 |
| GOLGA4 | golgin A4 | 0.0504858 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0500749 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0500414 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0470622 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0470402 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0468074 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0454474 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0451033 |
| RTN4 | reticulon 4 | 0.043503 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0431341 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0430042 |
| B2M | beta-2-microglobulin | 0.0417514 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0414742 |
| SRPK2 | SRSF protein kinase 2 | 0.0411003 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0410968 |
| KYNU | kynureninase | 0.0408682 |
| ANXA1 | annexin A1 | 0.0394068 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0389447 |
| CA12 | carbonic anhydrase XII | 0.0388701 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0386758 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0379512 |
| SAR1A | secretion associated, Ras related GTPase 1A | 0.0372342 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0360892 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.0356196 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0353198 |
| PUM1 | pumilio RNA-binding family member 1 | 0.034817 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0347562 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0346281 |
| HDLBP | high density lipoprotein binding protein | 0.0345897 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0338825 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0335616 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0327282 |
| RPL4 | ribosomal protein L4 | 0.0326651 |
| PHF3 | PHD finger protein 3 | 0.0324059 |
| NAV2 | neuron navigator 2 | 0.0323611 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0321378 |
| SMYD3 | SET and MYND domain containing 3 | 0.0319927 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0317623 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0314423 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0312719 |
| TFG | TRK-fused gene | 0.0309871 |
| RNF149 | ring finger protein 149 | 0.0308243 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.030469 |
| CDC27 | cell division cycle 27 | 0.0297132 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0294084 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | 0.0293874 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0293233 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0291593 |
| INSIG2 | insulin induced gene 2 | 0.0290662 |
| SRP54 | signal recognition particle 54kDa | 0.0290181 |
| TXNDC11 | thioredoxin domain containing 11 | 0.0285481 |
| PHF21A | PHD finger protein 21A | 0.0283706 |
| NABP1 | nucleic acid binding protein 1 | 0.0282779 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0282029 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0276168 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0275006 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.027276 |
| AGR2 | anterior gradient 2 | 0.02713 |
| TXNRD1 | thioredoxin reductase 1 | 0.0270858 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0270086 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0269661 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0268699 |
| PEG10 | paternally expressed 10 | 0.0268297 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0267812 |
| RPL27A | ribosomal protein L27a | 0.0267748 |
| SBF2 | SET binding factor 2 | 0.0265683 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0263921 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0263018 |
| FAM13A | family with sequence similarity 13, member A | 0.026176 |
| RIGI | RNA sensor RIG-I | 0.0261749 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0261233 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0261116 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.02581 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0257718 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0256759 |
| ANXA2 | annexin A2 | 0.0254514 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0251612 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0250772 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0250352 |
| ETV6 | ets variant 6 | 0.0250158 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0247845 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0245809 |
| MAP1B | microtubule-associated protein 1B | 0.0242455 |
| RPL3 | ribosomal protein L3 | 0.0239209 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0235121 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0234024 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0233958 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.102896 |
| MYO1E | myosin IE | -0.102774 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.101992 |
| LMO7 | LIM domain 7 | -0.096701 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0804428 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0707735 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0665457 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0635206 |
| MUC16 | mucin 16, cell surface associated | -0.0619722 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0585462 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0559636 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0531073 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0526517 |
| SVIL | supervillin | -0.0514865 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0489662 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0487883 |
| VIM | vimentin | -0.0487271 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0485898 |
| BPTF | bromodomain PHD finger transcription factor | -0.0475736 |
| OSMR | oncostatin M receptor | -0.0462357 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0442682 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0442421 |
| VMP1 | vacuole membrane protein 1 | -0.042208 |
| ERBIN | erbb2 interacting protein | -0.0416323 |
| LAMC2 | laminin, gamma 2 | -0.0406897 |
| RBM47 | RNA binding motif protein 47 | -0.0400063 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0398574 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0398091 |
| NHSL1 | NHS-like 1 | -0.0383713 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0380669 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0377022 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.036832 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.036816 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0361101 |
| RYBP | RING1 and YY1 binding protein | -0.0355496 |
| LAMB3 | laminin, beta 3 | -0.0352631 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0352545 |
| GPC6 | glypican 6 | -0.0351512 |
| S100A9 | S100 calcium binding protein A9 | -0.0351065 |
| HLA-B | major histocompatibility complex, class I, B | -0.034916 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0347966 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.034733 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0347303 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0345941 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0344157 |
| RAI14 | retinoic acid induced 14 | -0.0338042 |
| JUP | junction plakoglobin | -0.0334521 |
| H3-3B | H3.3 histone B | -0.0332257 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0321602 |
| RREB1 | ras responsive element binding protein 1 | -0.0321562 |
| ATOSA | atos homolog A | -0.0319605 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0309434 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.030855 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0305903 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0301693 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0301354 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0300291 |
| MEF2A | myocyte enhancer factor 2A | -0.0296743 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0296259 |
| RUNX1 | runt-related transcription factor 1 | -0.029424 |
| FMN1 | formin 1 | -0.0294213 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0293228 |
| GLIS3 | GLIS family zinc finger 3 | -0.029268 |
| CUX1 | cut-like homeobox 1 | -0.0291309 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0286312 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0283569 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0283307 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.0280882 |
| ATXN1 | ataxin 1 | -0.0279943 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0275535 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0274887 |
| CD109 | CD109 molecule | -0.02711 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0269256 |
| CLDN4 | claudin 4 | -0.0267972 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0267698 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0267412 |
| VEGFA | vascular endothelial growth factor A | -0.0265102 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0263273 |
| MYO5B | myosin VB | -0.0263142 |
| ACTG1 | actin gamma 1 | -0.0262485 |
| AK1 | adenylate kinase 1 | -0.0262061 |
| ABHD17C | abhydrolase domain containing 17C | -0.0255965 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0255909 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0254057 |
| SLMAP | sarcolemma associated protein | -0.0252475 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0250663 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0250361 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0247054 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0245648 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.024551 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0245494 |
| BCL2L1 | BCL2-like 1 | -0.0245264 |
| FOXO3 | forkhead box O3 | -0.0241758 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.024057 |
| THRB | thyroid hormone receptor, beta | -0.0240541 |
| FOXP1 | forkhead box P1 | -0.0239295 |
| DST | dystonin | -0.0235795 |
| INHBA | inhibin, beta A | -0.0235157 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0231585 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0230645 |
