Tirabrutinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tirabrutinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.1959
RAD51B RAD51 paralog B 0.0884409
PDE4D phosphodiesterase 4D, cAMP-specific 0.0854382
GRAMD1B GRAM domain containing 1B 0.0841696
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.075773
THSD4 thrombospondin, type I, domain containing 4 0.0710373
ERRFI1 ERBB receptor feedback inhibitor 1 0.0694522
TRIO trio Rho guanine nucleotide exchange factor 0.0551453
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0486675
EXOC4 exocyst complex component 4 0.0479491
PDE10A phosphodiesterase 10A 0.0449914
TAS2R14 taste receptor, type 2, member 14 0.0437164
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0432641
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0429853
TXNRD1 thioredoxin reductase 1 0.0425896
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0408949
ANKRD36 ankyrin repeat domain 36 0.0401616
DOCK5 dedicator of cytokinesis 5 0.0388887
ATXN1 ataxin 1 0.0387032
SMAD3 SMAD family member 3 0.0377898
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0377448
PTK2 protein tyrosine kinase 2 0.0376417
MACF1 microtubule-actin crosslinking factor 1 0.0369502
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0348744
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0342839
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0318042
PYGL phosphorylase, glycogen, liver 0.0309996
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0304028
FMNL2 formin-like 2 0.0302573
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0300842
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0298967
DENND5B DENN/MADD domain containing 5B 0.0296326
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0286931
ANO6 anoctamin 6 0.0284596
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0276071
WWOX WW domain containing oxidoreductase 0.0273033
PRELID2 PRELI domain containing 2 0.0272057
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0271077
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.026804
AFF3 AF4/FMR2 family, member 3 0.0264489
OSMR oncostatin M receptor 0.0264189
PRKCE protein kinase C, epsilon 0.0260425
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0256729
SMYD3 SET and MYND domain containing 3 0.0256689
ZBTB20 zinc finger and BTB domain containing 20 0.0253359
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0251516
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0241158
MBD5 methyl-CpG binding domain protein 5 0.0233155
PUM2 pumilio RNA-binding family member 2 0.0228914
ATP11A ATPase, class VI, type 11A 0.0224923
JMJD1C jumonji domain containing 1C 0.0224874
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0220094
MYH9 myosin, heavy chain 9, non-muscle 0.0219596
CTTN cortactin 0.0218371
TBC1D5 TBC1 domain family, member 5 0.0218355
LOXL2 lysyl oxidase-like 2 0.0217743
EML4 echinoderm microtubule associated protein like 4 0.0217489
CAMTA1 calmodulin binding transcription activator 1 0.0217216
BABAM2 BRISC and BRCA1 A complex member 2 0.0216462
EHBP1 EH domain binding protein 1 0.0215919
PFKP phosphofructokinase, platelet 0.0215738
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0215174
ATP13A3 ATPase type 13A3 0.0214929
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0213494
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0212705
IGF1R insulin-like growth factor 1 receptor 0.0211318
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0210897
FER fer (fps/fes related) tyrosine kinase 0.020406
RIMS2 regulating synaptic membrane exocytosis 2 0.0199728
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0197641
KIAA1328 KIAA1328 0.0193367
CCDC91 coiled-coil domain containing 91 0.0186448
HSPA8 heat shock 70kDa protein 8 0.0185919
RABGAP1L RAB GTPase activating protein 1-like 0.0184536
SHB Src homology 2 domain containing adaptor protein B 0.0183909
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0183611
SENP6 SUMO1/sentrin specific peptidase 6 0.0181475
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0179275
SCAF8 SR-related CTD-associated factor 8 0.0177206
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0176533
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.017614
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.017607
ETV6 ets variant 6 0.0172544
FAM13A family with sequence similarity 13, member A 0.0171621
TBC1D22A TBC1 domain family, member 22A 0.0169826
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0166818
RASA2 RAS p21 protein activator 2 0.0166705
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0165452
NCOA7 nuclear receptor coactivator 7 0.016521
CEP250 centrosomal protein 250kDa 0.0165122
KDM2A lysine (K)-specific demethylase 2A 0.0163331
RNF213 ring finger protein 213 0.0162913
TRIP12 thyroid hormone receptor interactor 12 0.0162557
TPM3 tropomyosin 3 0.016202
KDM7A lysine (K)-specific demethylase 7A 0.0160914
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0160135
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0159741
DST dystonin 0.0159716
AHNAK AHNAK nucleoprotein 0.0158719
SNX9 sorting nexin 9 0.0158456

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.27197
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.145055
PTMA prothymosin, alpha -0.0907816
VIM vimentin -0.0898368
TMSB10 thymosin beta 10 -0.0764719
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0731505
TPI1 triosephosphate isomerase 1 -0.0694929
RPLP0 ribosomal protein, large, P0 -0.0669659
RPS8 ribosomal protein S8 -0.0633736
TFPI2 tissue factor pathway inhibitor 2 -0.0610544
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0599474
PFN1 profilin 1 -0.0586617
RPS21 ribosomal protein S21 -0.0557041
RPL23 ribosomal protein L23 -0.0527327
RPL12 ribosomal protein L12 -0.0520833
RPL37 ribosomal protein L37 -0.045311
EIF1 eukaryotic translation initiation factor 1 -0.0434927
RPLP1 ribosomal protein, large, P1 -0.0423783
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0416717
RPL26 ribosomal protein L26 -0.0397803
EGR1 early growth response 1 -0.0392254
RPL19 ribosomal protein L19 -0.0389956
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0389415
KTN1 kinectin 1 (kinesin receptor) -0.0383339
RPL8 ribosomal protein L8 -0.036991
RPS15 ribosomal protein S15 -0.0367593
RPS6 ribosomal protein S6 -0.0366382
TUBA1B tubulin, alpha 1b -0.0365251
RPS27 ribosomal protein S27 -0.0362848
RACK1 receptor for activated C kinase 1 -0.0360189
RPS29 ribosomal protein S29 -0.035279
RPL35A ribosomal protein L35a -0.0351095
MYL12B myosin, light chain 12B, regulatory -0.0347245
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0346438
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0335255
RPS3 ribosomal protein S3 -0.033064
RPS25 ribosomal protein S25 -0.0324841
RPS10 ribosomal protein S10 -0.0312985
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0305339
CSDE1 cold shock domain containing E1, RNA-binding -0.0304976
VDAC1 voltage-dependent anion channel 1 -0.0294327
HMGA1 high mobility group AT-hook 1 -0.029398
RPL32 ribosomal protein L32 -0.0291892
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0290976
LDHB lactate dehydrogenase B -0.028952
FTL ferritin, light polypeptide -0.0289458
UBC ubiquitin C -0.0286722
YBX1 Y box binding protein 1 -0.0286565
RPLP2 ribosomal protein, large, P2 -0.0285094
RPL37A ribosomal protein L37a -0.0284279
RPL11 ribosomal protein L11 -0.0282288
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0282081
MT2A metallothionein 2A -0.0280116
RPL31 ribosomal protein L31 -0.0279816
NAP1L1 nucleosome assembly protein 1-like 1 -0.02789
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0275567
RPS19 ribosomal protein S19 -0.0267365
RPS27A ribosomal protein S27a -0.0259574
RPL28 ribosomal protein L28 -0.0254174
RPL5 ribosomal protein L5 -0.0253546
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0251787
RPL35 ribosomal protein L35 -0.024992
S100A10 S100 calcium binding protein A10 -0.0249826
RPS14 ribosomal protein S14 -0.0247768
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0245929
RPS13 ribosomal protein S13 -0.0244571
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0242765
RPS12 ribosomal protein S12 -0.0242385
TPM2 tropomyosin 2 (beta) -0.0242369
ATP5F1E ATP synthase F1 subunit epsilon -0.0241932
CBX3 chromobox homolog 3 -0.0241297
RPL18 ribosomal protein L18 -0.0230974
RPS17 ribosomal protein S17 -0.022758
RPS23 ribosomal protein S23 -0.0225089
RPL9 ribosomal protein L9 -0.022508
PRRC2C proline-rich coiled-coil 2C -0.022104
RPS4X ribosomal protein S4, X-linked -0.0220042
PCBP2 poly(rC) binding protein 2 -0.0218546
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0215061
RPL34 ribosomal protein L34 -0.0213971
PDIA4 protein disulfide isomerase family A, member 4 -0.0211448
AHCYL1 adenosylhomocysteinase-like 1 -0.0210376
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0210281
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0206642
KRT18 keratin 18, type I -0.0203753
RPS16 ribosomal protein S16 -0.0202513
RPL27A ribosomal protein L27a -0.0202457
SEPTIN7 septin 7 -0.0199024
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0198988
PHIP pleckstrin homology domain interacting protein -0.0193753
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0193717
S100A6 S100 calcium binding protein A6 -0.0193659
GSTP1 glutathione S-transferase pi 1 -0.0193331
RPL36A ribosomal protein L36a -0.0192757
OAZ1 ornithine decarboxylase antizyme 1 -0.0192194
CCNI cyclin I -0.0191676
SMC4 structural maintenance of chromosomes 4 -0.018898
RPL7A ribosomal protein L7a -0.0188325
EIF5B eukaryotic translation initiation factor 5B -0.018814
KPNB1 karyopherin (importin) beta 1 -0.0187298