| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.0937143 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0844085 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0832202 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0822959 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0785699 |
| EFNA5 | ephrin-A5 | 0.0698507 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0680598 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0629412 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0622354 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0614114 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0472126 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0445657 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0444187 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0424531 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0418441 |
| ERBIN | erbb2 interacting protein | 0.0407277 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0398716 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.039601 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0384079 |
| POTEF | POTE ankyrin domain family, member F | 0.0373524 |
| PTK2 | protein tyrosine kinase 2 | 0.0365213 |
| MYO6 | myosin VI | 0.035448 |
| RCOR1 | REST corepressor 1 | 0.0343597 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0343108 |
| VCL | vinculin | 0.0338101 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0337303 |
| DTNA | dystrobrevin, alpha | 0.0336054 |
| FLNB | filamin B, beta | 0.0335865 |
| NAV2 | neuron navigator 2 | 0.0332815 |
| VEGFA | vascular endothelial growth factor A | 0.0332319 |
| FBXO32 | F-box protein 32 | 0.0332181 |
| MYO1E | myosin IE | 0.0320464 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0305373 |
| RAI14 | retinoic acid induced 14 | 0.0301602 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0297706 |
| RAD51B | RAD51 paralog B | 0.0290757 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0290219 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0283342 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0281154 |
| TMF1 | TATA element modulatory factor 1 | 0.0278733 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0278012 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0277985 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0277365 |
| GOLGB1 | golgin B1 | 0.0275009 |
| ATP11A | ATPase, class VI, type 11A | 0.0274625 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0272452 |
| CTBP2 | C-terminal binding protein 2 | 0.0268825 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.026841 |
| FNIP1 | folliculin interacting protein 1 | 0.0267076 |
| PLEC | plectin | 0.0266781 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0252751 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0248262 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0240294 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0232671 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0230888 |
| TMEM165 | transmembrane protein 165 | 0.0229749 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0227477 |
| VMP1 | vacuole membrane protein 1 | 0.0224228 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0221512 |
| TUFT1 | tuftelin 1 | 0.0221048 |
| RBM47 | RNA binding motif protein 47 | 0.021958 |
| MCU | mitochondrial calcium uniporter | 0.0218863 |
| MSN | moesin | 0.021834 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0217601 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0217444 |
| ATXN1 | ataxin 1 | 0.0217234 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0217007 |
| FBXO34 | F-box protein 34 | 0.021567 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0213963 |
| MYO5B | myosin VB | 0.0212078 |
| SMAD3 | SMAD family member 3 | 0.0212062 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0207867 |
| ARHGAP20 | Rho GTPase activating protein 20 | 0.0207302 |
| SCFD1 | sec1 family domain containing 1 | 0.0202561 |
| ATOSA | atos homolog A | 0.0202243 |
| FHIT | fragile histidine triad | 0.0201476 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0201025 |
| OCLN | occludin | 0.0198335 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0197963 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0197765 |
| SBF2 | SET binding factor 2 | 0.019741 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0196555 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0195023 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0193816 |
| LOXL2 | lysyl oxidase-like 2 | 0.0193068 |
| CAB39 | calcium binding protein 39 | 0.0192308 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0191017 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0189318 |
| PTK2B | protein tyrosine kinase 2 beta | 0.0188633 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0188383 |
| CCNY | cyclin Y | 0.0188243 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0188006 |
| FAM3C | family with sequence similarity 3, member C | 0.0187513 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0187482 |
| RNF213 | ring finger protein 213 | 0.0185778 |
| PRELID2 | PRELI domain containing 2 | 0.0184617 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0179237 |
| RUNX1 | runt-related transcription factor 1 | 0.0178682 |
| PRKCA | protein kinase C, alpha | 0.0178427 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0176563 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.3633 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.253023 |
| PTMA | prothymosin, alpha | -0.17435 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.16728 |
| FTL | ferritin, light polypeptide | -0.164826 |
| S100A6 | S100 calcium binding protein A6 | -0.134313 |
| TMSB10 | thymosin beta 10 | -0.105683 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.105244 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.100108 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0842094 |
| HMGA1 | high mobility group AT-hook 1 | -0.076656 |
| TMSB4X | thymosin beta 4, X-linked | -0.0766547 |
| UBC | ubiquitin C | -0.0764491 |
| S100A10 | S100 calcium binding protein A10 | -0.0712097 |
| RPLP0 | ribosomal protein, large, P0 | -0.070304 |
| RPLP1 | ribosomal protein, large, P1 | -0.068307 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0633597 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0630843 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0625638 |
| RPL8 | ribosomal protein L8 | -0.06095 |
| RPL23 | ribosomal protein L23 | -0.0601622 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0599324 |
| RPL34 | ribosomal protein L34 | -0.0589393 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0577502 |
| CANX | calnexin | -0.0577437 |
| MT2A | metallothionein 2A | -0.0577031 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.057228 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0568927 |
| RPL12 | ribosomal protein L12 | -0.0564382 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0559113 |
| RPS8 | ribosomal protein S8 | -0.0555644 |
| ASPH | aspartate beta-hydroxylase | -0.0545432 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0534438 |
| RPS6 | ribosomal protein S6 | -0.0519191 |
| RPL32 | ribosomal protein L32 | -0.0516228 |
| HMGB2 | high mobility group box 2 | -0.0506396 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0500105 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0499767 |
| RPS19 | ribosomal protein S19 | -0.0499661 |
| ANXA2 | annexin A2 | -0.0485921 |
| RPS3 | ribosomal protein S3 | -0.0474612 |
| RPL35A | ribosomal protein L35a | -0.0470286 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0462844 |
| CALR | calreticulin | -0.0457676 |
| RPLP2 | ribosomal protein, large, P2 | -0.0456247 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0450856 |
| RPL19 | ribosomal protein L19 | -0.0447401 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0442947 |
| FAM162A | family with sequence similarity 162, member A | -0.0440696 |
| ACTG1 | actin gamma 1 | -0.0408884 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0405896 |
| RPS27A | ribosomal protein S27a | -0.0403008 |
| YBX1 | Y box binding protein 1 | -0.0392814 |
| G0S2 | G0/G1 switch 2 | -0.0384503 |
| SQSTM1 | sequestosome 1 | -0.0381122 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0380297 |
| GNAS | GNAS complex locus | -0.0374789 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0374507 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0374258 |
| RPS24 | ribosomal protein S24 | -0.0371739 |
| RACK1 | receptor for activated C kinase 1 | -0.0368924 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0365208 |
| EPCAM | epithelial cell adhesion molecule | -0.0357311 |
| RPS14 | ribosomal protein S14 | -0.0356845 |
| VIM | vimentin | -0.0347167 |
| RPS23 | ribosomal protein S23 | -0.0345768 |
| KRT7 | keratin 7, type II | -0.0340528 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0340238 |
| CCNI | cyclin I | -0.0333074 |
| RPS13 | ribosomal protein S13 | -0.0325414 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0323655 |
| PGK1 | phosphoglycerate kinase 1 | -0.0318777 |
| PLAU | plasminogen activator, urokinase | -0.0309561 |
| CCND1 | cyclin D1 | -0.0305187 |
| LAMB3 | laminin, beta 3 | -0.029834 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0297908 |
| RPL27A | ribosomal protein L27a | -0.0296524 |
| DEK | DEK proto-oncogene | -0.0291069 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0289941 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0289222 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0288346 |
| RPL7 | ribosomal protein L7 | -0.0281503 |
| TXNRD1 | thioredoxin reductase 1 | -0.0278227 |
| RPL26 | ribosomal protein L26 | -0.0278028 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0274032 |
| RPL9 | ribosomal protein L9 | -0.0273353 |
| ANLN | anillin, actin binding protein | -0.0273314 |
| TKT | transketolase | -0.0273012 |
| RPL28 | ribosomal protein L28 | -0.0270476 |
| ENO1 | enolase 1, (alpha) | -0.0269673 |
| RPL18 | ribosomal protein L18 | -0.026804 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0267698 |
| LAMC2 | laminin, gamma 2 | -0.0266278 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0265341 |
| AHNAK | AHNAK nucleoprotein | -0.0264704 |
| RLF | rearranged L-myc fusion | -0.0263655 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0259394 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0259251 |
| S100A9 | S100 calcium binding protein A9 | -0.0258735 |
| RPS25 | ribosomal protein S25 | -0.0258695 |
