| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.167799 |
| GRAMD1B | GRAM domain containing 1B | 0.114822 |
| PM20D1 | peptidase M20 domain containing 1 | 0.110907 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.108387 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.100501 |
| ASPH | aspartate beta-hydroxylase | 0.0985279 |
| MCL1 | myeloid cell leukemia 1 | 0.0938558 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0915743 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0907422 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0773176 |
| DST | dystonin | 0.0734811 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0724704 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0722287 |
| TBXT | T-box transcription factor T | 0.0677618 |
| NRCAM | neuronal cell adhesion molecule | 0.0674528 |
| TXNRD1 | thioredoxin reductase 1 | 0.0664606 |
| FLNB | filamin B, beta | 0.062661 |
| MT2A | metallothionein 2A | 0.0610896 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0609395 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0605275 |
| CENPF | centromere protein F, 350/400kDa | 0.0604321 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0602728 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0572121 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0558908 |
| EFNA5 | ephrin-A5 | 0.0558337 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0553966 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0551893 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0544171 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0542472 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0538157 |
| POTEF | POTE ankyrin domain family, member F | 0.0531937 |
| PDE10A | phosphodiesterase 10A | 0.0528351 |
| MYOF | myoferlin | 0.0527483 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0522726 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0520919 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0506577 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0505976 |
| FTL | ferritin, light polypeptide | 0.0490853 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0490487 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0480688 |
| PCBP2 | poly(rC) binding protein 2 | 0.0478581 |
| MSN | moesin | 0.0477001 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0474862 |
| RPL3 | ribosomal protein L3 | 0.0464264 |
| MKI67 | marker of proliferation Ki-67 | 0.0450638 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.043835 |
| MFF | mitochondrial fission factor | 0.0432319 |
| PCBP3 | poly(rC) binding protein 3 | 0.0415813 |
| PTGR1 | prostaglandin reductase 1 | 0.0413097 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0407575 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0400145 |
| EZR | ezrin | 0.039938 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.039206 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0390273 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0383969 |
| NDRG1 | N-myc downstream regulated 1 | 0.0382159 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0379753 |
| COL5A2 | collagen, type V, alpha 2 | 0.0376032 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0369007 |
| LDHA | lactate dehydrogenase A | 0.035969 |
| GPC6 | glypican 6 | 0.0356591 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0355811 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0353799 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0350705 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0348712 |
| BDNF | brain-derived neurotrophic factor | 0.0344687 |
| ENO1 | enolase 1, (alpha) | 0.0339867 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0337386 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0335119 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0332961 |
| RGS2 | regulator of G-protein signaling 2 | 0.0328032 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0322605 |
| ZNF292 | zinc finger protein 292 | 0.0320883 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0314748 |
| VMP1 | vacuole membrane protein 1 | 0.0313327 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0311022 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0307584 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0302609 |
| CD109 | CD109 molecule | 0.0302518 |
| NHSL1 | NHS-like 1 | 0.0302177 |
| PYGL | phosphorylase, glycogen, liver | 0.0290727 |
| PRKD3 | protein kinase D3 | 0.0288754 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0285972 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0282509 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0281202 |
| DNER | delta/notch-like EGF repeat containing | 0.0279952 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0278403 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0276981 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0274983 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0272633 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0272589 |
| TPM3 | tropomyosin 3 | 0.0271978 |
| ITGA6 | integrin, alpha 6 | 0.0270089 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0266094 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.026543 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0262874 |
| PRELID2 | PRELI domain containing 2 | 0.0261464 |
| FAM13A | family with sequence similarity 13, member A | 0.0260624 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0258202 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0258183 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.205704 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.178046 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.133275 |
| CDH13 | cadherin 13 | -0.12005 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0989651 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0938743 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.088166 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0639429 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0634624 |
| RPS24 | ribosomal protein S24 | -0.0606881 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0558976 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0550351 |
| CANX | calnexin | -0.0547291 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.049023 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0467792 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0440869 |
| SMYD3 | SET and MYND domain containing 3 | -0.0435278 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0410207 |
| HLA-B | major histocompatibility complex, class I, B | -0.0398355 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0391599 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0357739 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0343097 |
| PTMA | prothymosin, alpha | -0.0323833 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0297022 |
| SQSTM1 | sequestosome 1 | -0.0287571 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0276119 |
| ARF1 | ADP-ribosylation factor 1 | -0.0275293 |
| PLCB4 | phospholipase C, beta 4 | -0.0272512 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0272195 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0272144 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0268736 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0257496 |
| DENND1A | DENN/MADD domain containing 1A | -0.0256495 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.025619 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0252327 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0246474 |
| VCL | vinculin | -0.0241783 |
| CDK13 | cyclin-dependent kinase 13 | -0.023942 |
| AOPEP | aminopeptidase O (putative) | -0.0237338 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0234227 |
| RANBP17 | RAN binding protein 17 | -0.0234096 |
| WDR43 | WD repeat domain 43 | -0.0234025 |
| RPL26 | ribosomal protein L26 | -0.0234002 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0233344 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0228191 |
| CUX1 | cut-like homeobox 1 | -0.0227605 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0222489 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0221742 |
| GDA | guanine deaminase | -0.0221684 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0219397 |
| SMAD2 | SMAD family member 2 | -0.0219018 |
| NTN4 | netrin 4 | -0.0217015 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0215176 |
| FNDC3A | fibronectin type III domain containing 3A | -0.021064 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0210127 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0208524 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0207463 |
| S100A6 | S100 calcium binding protein A6 | -0.0205596 |
| ANTXR1 | anthrax toxin receptor 1 | -0.020551 |
| NCKAP5 | NCK-associated protein 5 | -0.0204578 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0204231 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0203672 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.02036 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0201317 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0199723 |
| HDLBP | high density lipoprotein binding protein | -0.0196469 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.019184 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0191682 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0191031 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0190586 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0189795 |
| CD44 | CD44 molecule (Indian blood group) | -0.0188388 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0187591 |
| BMERB1 | bMERB domain containing 1 | -0.0183884 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0180887 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0180019 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0178891 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0177776 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.017702 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0176339 |
| USP15 | ubiquitin specific peptidase 15 | -0.01761 |
| STEAP1B | STEAP family member 1B | -0.0175448 |
| RAB31 | RAB31, member RAS oncogene family | -0.0175011 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0174046 |
| FOXC1 | forkhead box C1 | -0.0172841 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0170486 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0167904 |
| AEBP2 | AE binding protein 2 | -0.0165823 |
| RPL34 | ribosomal protein L34 | -0.0165053 |
| RASAL2 | RAS protein activator like 2 | -0.0164323 |
| NF1 | neurofibromin 1 | -0.0164304 |
| MYPN | myopalladin | -0.016266 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0161522 |
| RPS27A | ribosomal protein S27a | -0.0160804 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0159265 |
| RPL38 | ribosomal protein L38 | -0.0159083 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0158738 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0157691 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0156523 |
| AUTS2 | autism susceptibility candidate 2 | -0.0155558 |
