Tirabrutinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

69 genes differentially expressed following the Tirabrutinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANKRD11 ankyrin repeat domain 11 0.0923883
NCOA3 nuclear receptor coactivator 3 0.07673
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0605928
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0601059
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0541957
RBM39 RNA binding motif protein 39 0.0535188
THSD4 thrombospondin, type I, domain containing 4 0.0519461
ZNF292 zinc finger protein 292 0.0516708
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0503059
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0462986
EGR1 early growth response 1 0.0460398
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0421565
WAC WW domain containing adaptor with coiled-coil 0.0414937
RBM25 RNA binding motif protein 25 0.0402127
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0363362
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0355119
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031906
MED13L mediator complex subunit 13-like 0.0313735
KMT2C lysine (K)-specific methyltransferase 2C 0.0308479
PTPRM protein tyrosine phosphatase, receptor type, M 0.0297812
SENP6 SUMO1/sentrin specific peptidase 6 0.0267852
RPS6 ribosomal protein S6 0.0255336
NEBL nebulette 0.0243306
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0241156
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0231431
ZSWIM6 zinc finger, SWIM-type containing 6 0.022778
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0175008
FNDC3B fibronectin type III domain containing 3B 0.0173751
PTMA prothymosin, alpha 0.0148401
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0145352
SBF2 SET binding factor 2 0.0101247
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00983386
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.00934751
DSCAM Down syndrome cell adhesion molecule 0.00894045
IGFBP3 insulin-like growth factor binding protein 3 0.00839918
JMJD1C jumonji domain containing 1C 0.00728149
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00596619
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0058645
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 9.37904E-4
TPM4 tropomyosin 4 3.44142E-6

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.113647
FN1 fibronectin 1 -0.101743
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0933517
NDRG1 N-myc downstream regulated 1 -0.0607102
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0497759
EGFR epidermal growth factor receptor -0.0474166
TMSB10 thymosin beta 10 -0.047087
EXT1 exostosin glycosyltransferase 1 -0.0465499
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0446122
FTL ferritin, light polypeptide -0.0401813
AKAP12 A kinase (PRKA) anchor protein 12 -0.0392423
TRIO trio Rho guanine nucleotide exchange factor -0.0382001
RPS3 ribosomal protein S3 -0.0333358
CD44 CD44 molecule (Indian blood group) -0.0319592
PRKCA protein kinase C, alpha -0.0300672
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0296673
USP34 ubiquitin specific peptidase 34 -0.0275771
PTK2 protein tyrosine kinase 2 -0.0240704
ZBTB20 zinc finger and BTB domain containing 20 -0.0239036
ASPH aspartate beta-hydroxylase -0.0229594
MYO1E myosin IE -0.0219973
LDHA lactate dehydrogenase A -0.0164327
SQSTM1 sequestosome 1 -0.0161404
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0118258
RAD51B RAD51 paralog B -0.0108996
MT2A metallothionein 2A -0.00930716
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.00903387
SLC38A1 solute carrier family 38, member 1 -0.00622171
MYO6 myosin VI -0.00434582