| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.172079 |
| PEG10 | paternally expressed 10 | 0.115161 |
| PHIP | pleckstrin homology domain interacting protein | 0.0780527 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0713328 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.068595 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0623985 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0607808 |
| CENPF | centromere protein F, 350/400kDa | 0.0549718 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.053562 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0511398 |
| PGK1 | phosphoglycerate kinase 1 | 0.0506815 |
| FOXP2 | forkhead box P2 | 0.0471893 |
| PLPP1 | phospholipid phosphatase 1 | 0.0451405 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.044088 |
| FAM171B | family with sequence similarity 171, member B | 0.0431403 |
| TENM3 | teneurin transmembrane protein 3 | 0.0418572 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0418517 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0404465 |
| AHNAK | AHNAK nucleoprotein | 0.0394604 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0393205 |
| RPL4 | ribosomal protein L4 | 0.0389914 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0372115 |
| ENO1 | enolase 1, (alpha) | 0.0370234 |
| RPS4X | ribosomal protein S4, X-linked | 0.0363641 |
| POTEF | POTE ankyrin domain family, member F | 0.0361679 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.035484 |
| H1-0 | H1.0 linker histone | 0.035443 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0353917 |
| LRRC4C | leucine rich repeat containing 4C | 0.0351045 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0347643 |
| PFN1 | profilin 1 | 0.0342694 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0338792 |
| SMAD2 | SMAD family member 2 | 0.0335917 |
| CDH19 | cadherin 19, type 2 | 0.0335363 |
| RIGI | RNA sensor RIG-I | 0.0335352 |
| CALR | calreticulin | 0.0328433 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0318273 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0317316 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0311572 |
| TBC1D32 | TBC1 domain family, member 32 | 0.0311424 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0308024 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0305486 |
| FAT1 | FAT atypical cadherin 1 | 0.0305202 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0304888 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0303742 |
| SYT1 | synaptotagmin I | 0.0301145 |
| JMJD1C | jumonji domain containing 1C | 0.0301066 |
| GAB2 | GRB2-associated binding protein 2 | 0.0299781 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0299454 |
| METAP2 | methionyl aminopeptidase 2 | 0.0297783 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0296332 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0296103 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0295838 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0293802 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0287166 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0287124 |
| MTF2 | metal response element binding transcription factor 2 | 0.0286227 |
| SKIL | SKI-like proto-oncogene | 0.0284613 |
| LDHA | lactate dehydrogenase A | 0.0284253 |
| NBEAL1 | neurobeachin-like 1 | 0.0283604 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0282095 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0280803 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0280308 |
| GPC3 | glypican 3 | 0.0278548 |
| DACH1 | dachshund family transcription factor 1 | 0.0277089 |
| RASAL2 | RAS protein activator like 2 | 0.0275282 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0272368 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.0271549 |
| COL5A2 | collagen, type V, alpha 2 | 0.0271191 |
| ARHGAP15 | Rho GTPase activating protein 15 | 0.0270527 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0269657 |
| ZNF462 | zinc finger protein 462 | 0.0264593 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0264473 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0263881 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0261167 |
| BRD2 | bromodomain containing 2 | 0.0261079 |
| INSIG2 | insulin induced gene 2 | 0.0258557 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0258494 |
| ZDBF2 | zinc finger, DBF-type containing 2 | 0.0257615 |
| KIF2A | kinesin heavy chain member 2A | 0.0256276 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0256262 |
| TMEM9 | transmembrane protein 9 | 0.0255171 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0254804 |
| EXOC1 | exocyst complex component 1 | 0.0251309 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0251285 |
| RPL35A | ribosomal protein L35a | 0.0247944 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.024666 |
| RPL3 | ribosomal protein L3 | 0.0246378 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0246263 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 0.0246178 |
| CCDC102B | coiled-coil domain containing 102B | 0.0245172 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0244794 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 0.0244374 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0244197 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0243293 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.0241549 |
| TJP1 | tight junction protein 1 | 0.023845 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0238154 |
| RAD51B | RAD51 paralog B | 0.0238132 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0232704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.129562 |
| TMSB4X | thymosin beta 4, X-linked | -0.100576 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0986357 |
| VIM | vimentin | -0.0874653 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0848768 |
| RPS6 | ribosomal protein S6 | -0.0744838 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0741292 |
| CADM2 | cell adhesion molecule 2 | -0.0726728 |
| HDAC9 | histone deacetylase 9 | -0.0650459 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0612534 |
| RPS16 | ribosomal protein S16 | -0.0592718 |
| ITGAV | integrin, alpha V | -0.0583348 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.0556395 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0546344 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.054018 |
| SNX6 | sorting nexin 6 | -0.0534622 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0523495 |
| APP | amyloid beta (A4) precursor protein | -0.0522777 |
| RPS2 | ribosomal protein S2 | -0.0498494 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0486339 |
| MYO10 | myosin X | -0.0483316 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0477464 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0474462 |
| H1-4 | H1.4 linker histone, cluster member | -0.0461977 |
| RPL37 | ribosomal protein L37 | -0.0447938 |
| PDCD5 | programmed cell death 5 | -0.0442883 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.044166 |
| RBM39 | RNA binding motif protein 39 | -0.0439495 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0437824 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0433604 |
| SRP54 | signal recognition particle 54kDa | -0.0431943 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0419383 |
| H1-5 | H1.5 linker histone, cluster member | -0.0407156 |
| RPS10 | ribosomal protein S10 | -0.040062 |
| HMCN1 | hemicentin 1 | -0.0394088 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0392468 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0391648 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0391291 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0387836 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.038589 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0385835 |
| SMYD3 | SET and MYND domain containing 3 | -0.0381121 |
| MAP4 | microtubule-associated protein 4 | -0.0380098 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.03766 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0375631 |
| CRY1 | cryptochrome circadian clock 1 | -0.036899 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0367634 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0365434 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0364924 |
| ADNP | activity-dependent neuroprotector homeobox | -0.036174 |
| UPP1 | uridine phosphorylase 1 | -0.0360609 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0356719 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0355276 |
| ACTG1 | actin gamma 1 | -0.0354474 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0349795 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0342761 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0342593 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.033919 |
| EMP1 | epithelial membrane protein 1 | -0.0338186 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0337628 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0335274 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0334202 |
| NUP98 | nucleoporin 98kDa | -0.0334065 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0329983 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0326324 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0326318 |
| OGA | O-GlcNAcase | -0.0326233 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0325468 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0324974 |
| NCOR1 | nuclear receptor corepressor 1 | -0.032292 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0322702 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0319362 |
| CLTC | clathrin, heavy chain (Hc) | -0.0318383 |
| HDAC2 | histone deacetylase 2 | -0.0317195 |
| RPS21 | ribosomal protein S21 | -0.031592 |
| CFL2 | cofilin 2 (muscle) | -0.0313451 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0312258 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0311279 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0310214 |
| SBF2 | SET binding factor 2 | -0.030995 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0306481 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0306005 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.030572 |
| MLEC | malectin | -0.0299039 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0298657 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.029606 |
| RBM25 | RNA binding motif protein 25 | -0.0295744 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0295577 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0291313 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0290485 |
| LDHB | lactate dehydrogenase B | -0.028872 |
| TNRC6B | trinucleotide repeat containing 6B | -0.028699 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0286224 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0286063 |
| GPHN | gephyrin | -0.0285031 |
| RPLP2 | ribosomal protein, large, P2 | -0.0283378 |
| RNGTT | RNA guanylyltransferase and 5'-phosphatase | -0.0283039 |
| NF1 | neurofibromin 1 | -0.0282991 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0281026 |
| PAPOLA | poly(A) polymerase alpha | -0.0280486 |
