Tirabrutinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.188584
RBMS3 RNA binding motif, single stranded interacting protein 3 0.149
PRELID2 PRELI domain containing 2 0.109711
SOX6 SRY (sex determining region Y)-box 6 0.105871
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.103486
DLG1 discs, large homolog 1 (Drosophila) 0.0907669
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0804708
TJP1 tight junction protein 1 0.0791158
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0774107
ADAM10 ADAM metallopeptidase domain 10 0.0767083
PDE4D phosphodiesterase 4D, cAMP-specific 0.0763336
FLNB filamin B, beta 0.0749231
EFNA5 ephrin-A5 0.0746754
NBEA neurobeachin 0.0706086
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0700557
ENO1 enolase 1, (alpha) 0.0696988
SBF2 SET binding factor 2 0.0683789
ASPH aspartate beta-hydroxylase 0.065144
SMYD3 SET and MYND domain containing 3 0.0646059
NPAS2 neuronal PAS domain protein 2 0.0645222
TMEM65 transmembrane protein 65 0.0612828
POTEF POTE ankyrin domain family, member F 0.0594162
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0594007
MACROD2 MACRO domain containing 2 0.0583601
CAMTA1 calmodulin binding transcription activator 1 0.0572559
DPYD dihydropyrimidine dehydrogenase 0.0545171
ANKRD36 ankyrin repeat domain 36 0.0517866
FHIT fragile histidine triad 0.0507539
ANKRD12 ankyrin repeat domain 12 0.0505122
ZNF608 zinc finger protein 608 0.0500851
NAV2 neuron navigator 2 0.0498361
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0468461
HDAC9 histone deacetylase 9 0.0464216
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.04583
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0456636
VIM vimentin 0.0453214
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0452905
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0449617
NFIA nuclear factor I/A 0.0447525
CENPF centromere protein F, 350/400kDa 0.0446007
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0426625
TTC28 tetratricopeptide repeat domain 28 0.0425859
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0419963
TBC1D22A TBC1 domain family, member 22A 0.0417361
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0409935
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0402378
TXNRD1 thioredoxin reductase 1 0.0402308
RPS8 ribosomal protein S8 0.0400818
DIAPH3 diaphanous-related formin 3 0.0396803
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.039548
SDK1 sidekick cell adhesion molecule 1 0.0391557
RPL31 ribosomal protein L31 0.0385517
CD47 CD47 molecule 0.0382421
NDRG1 N-myc downstream regulated 1 0.0381691
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0377627
SMC4 structural maintenance of chromosomes 4 0.0375836
ENO2 enolase 2 (gamma, neuronal) 0.0373003
RPL9 ribosomal protein L9 0.0370313
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.036387
EZR ezrin 0.0356357
VCL vinculin 0.0350982
RPL3 ribosomal protein L3 0.0349427
USP34 ubiquitin specific peptidase 34 0.0349423
HJURP Holliday junction recognition protein 0.0347698
FNIP1 folliculin interacting protein 1 0.0341992
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0339926
FOXP1 forkhead box P1 0.0339017
FN1 fibronectin 1 0.0336169
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0332024
DIAPH2 diaphanous-related formin 2 0.0331415
YEATS2 YEATS domain containing 2 0.032898
ZBTB20 zinc finger and BTB domain containing 20 0.0325383
APLP2 amyloid beta (A4) precursor-like protein 2 0.0317032
MKI67 marker of proliferation Ki-67 0.0316097
TAS2R14 taste receptor, type 2, member 14 0.0309133
RPL37A ribosomal protein L37a 0.0309073
PTPRG protein tyrosine phosphatase, receptor type, G 0.0307914
BABAM2 BRISC and BRCA1 A complex member 2 0.0301005
FAT1 FAT atypical cadherin 1 0.0300141
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0298773
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.029605
LIMCH1 LIM and calponin homology domains 1 0.029514
PDGFC platelet derived growth factor C 0.0294677
PDIA3 protein disulfide isomerase family A, member 3 0.0293435
GLI2 GLI family zinc finger 2 0.0292795
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0290684
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0289261
ZMYM2 zinc finger, MYM-type 2 0.0288854
KDM4C lysine (K)-specific demethylase 4C 0.0288651
DST dystonin 0.0288624
SLC38A2 solute carrier family 38, member 2 0.0288528
FAM13A family with sequence similarity 13, member A 0.0286424
NBEAL1 neurobeachin-like 1 0.0280298
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0280098
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0280069
ZMYND8 zinc finger, MYND-type containing 8 0.0279249
PKM pyruvate kinase, muscle 0.0278672
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0278518
BRD2 bromodomain containing 2 0.027841
PGK1 phosphoglycerate kinase 1 0.0276517

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148532
PTMA prothymosin, alpha -0.0822567
RTN4 reticulon 4 -0.0759492
GARS1 glycyl-tRNA synthetase 1 -0.0698349
S100A6 S100 calcium binding protein A6 -0.0631116
ZFAND3 zinc finger, AN1-type domain 3 -0.0552644
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0539259
LOC112694756 uncharaterized LOC112694756 -0.0487817
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0487074
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0457496
RBM39 RNA binding motif protein 39 -0.0454665
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0435515
TMEM41B transmembrane protein 41B -0.0420564
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0375916
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0359309
EIF1 eukaryotic translation initiation factor 1 -0.0355521
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0346078
TMSB4X thymosin beta 4, X-linked -0.032953
ELOVL5 ELOVL fatty acid elongase 5 -0.0316645
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0306212
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.030215
S100A4 S100 calcium binding protein A4 -0.0284188
NAP1L1 nucleosome assembly protein 1-like 1 -0.028133
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0278085
RNF145 ring finger protein 145 -0.0270954
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0270711
RBM25 RNA binding motif protein 25 -0.0268597
ANKRD11 ankyrin repeat domain 11 -0.0266752
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0254913
ACACA acetyl-CoA carboxylase alpha -0.0249378
WAC WW domain containing adaptor with coiled-coil -0.0243915
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0240339
CDC73 cell division cycle 73 -0.0239441
XRN2 5'-3' exoribonuclease 2 -0.0234239
MARS1 methionyl-tRNA synthetase 1 -0.0233759
TARS1 threonyl-tRNA synthetase 1 -0.0229483
CCNL1 cyclin L1 -0.0223568
DDIT4 DNA-damage-inducible transcript 4 -0.0222529
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0222311
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.021941
RLF rearranged L-myc fusion -0.0215646
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0208748
PHF14 PHD finger protein 14 -0.0208257
CRY1 cryptochrome circadian clock 1 -0.0204882
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0204079
LIMD1 LIM domains containing 1 -0.0200843
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0198367
PUM2 pumilio RNA-binding family member 2 -0.019568
ATOSA atos homolog A -0.0194334
MARCHF6 membrane associated ring-CH-type finger 6 -0.0193337
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.019192
ANK2 ankyrin 2, neuronal -0.0191681
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0191375
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0191203
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0191039
ECT2 epithelial cell transforming 2 -0.0190239
NT5C2 5'-nucleotidase, cytosolic II -0.0184717
SESN2 sestrin 2 -0.0181415
ZEB1 zinc finger E-box binding homeobox 1 -0.0181172
PHF3 PHD finger protein 3 -0.0180665
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0180495
NUP98 nucleoporin 98kDa -0.0179101
PUM1 pumilio RNA-binding family member 1 -0.0176481
SEC24D SEC24 family member D -0.0175304
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0174858
NOP58 NOP58 ribonucleoprotein -0.0174756
BIRC2 baculoviral IAP repeat containing 2 -0.0174689
RAD21 RAD21 homolog (S. pombe) -0.0171914
ZNF644 zinc finger protein 644 -0.0171752
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0171512
RPS24 ribosomal protein S24 -0.0170587
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0170232
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0169343
ZC3H15 zinc finger CCCH-type containing 15 -0.0169139
CCNI cyclin I -0.0166888
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.016687
WDR36 WD repeat domain 36 -0.0166656
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.0166259
RIGI RNA sensor RIG-I -0.0163926
UFM1 ubiquitin-fold modifier 1 -0.0163472
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0162244
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0161818
CENATAC centrosomal AT-AC splicing factor -0.0160049
NCEH1 neutral cholesterol ester hydrolase 1 -0.0158104
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0157402
HDLBP high density lipoprotein binding protein -0.015558
STAU1 staufen double-stranded RNA binding protein 1 -0.015551
EML4 echinoderm microtubule associated protein like 4 -0.0153365
TM9SF3 transmembrane 9 superfamily member 3 -0.0152124
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0152086
PITPNB phosphatidylinositol transfer protein, beta -0.0151609
TMEM39A transmembrane protein 39A -0.0150888
SAFB2 scaffold attachment factor B2 -0.0150535
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0149854
UNC5C unc-5 homolog C (C. elegans) -0.0149504
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.014922
RBM27 RNA binding motif protein 27 -0.0148514
B2M beta-2-microglobulin -0.0148257
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0148246
IARS1 isoleucyl-tRNA synthetase 1 -0.0147912