| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.250897 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.197148 |
| FNDC3B | fibronectin type III domain containing 3B | 0.180131 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.156489 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.123274 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.117095 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.111047 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.103244 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0961502 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0939194 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0874962 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.084778 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.075837 |
| MSN | moesin | 0.0755988 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0750439 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0714737 |
| VCL | vinculin | 0.0713607 |
| RTN4 | reticulon 4 | 0.068778 |
| ZNF292 | zinc finger protein 292 | 0.0679636 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0664773 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0645998 |
| ARRDC3 | arrestin domain containing 3 | 0.0645757 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.060602 |
| SMAD3 | SMAD family member 3 | 0.0598418 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0593458 |
| MYOF | myoferlin | 0.0588233 |
| VMP1 | vacuole membrane protein 1 | 0.0587491 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0582888 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.057463 |
| MKI67 | marker of proliferation Ki-67 | 0.0569389 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0559088 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0550046 |
| THBS1 | thrombospondin 1 | 0.0540442 |
| FLNB | filamin B, beta | 0.0513668 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.050997 |
| BICC1 | BicC family RNA binding protein 1 | 0.0509462 |
| CD44 | CD44 molecule (Indian blood group) | 0.0506184 |
| DST | dystonin | 0.0498088 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0491698 |
| VCAN | versican | 0.0482991 |
| TXNIP | thioredoxin interacting protein | 0.0482696 |
| JMJD1C | jumonji domain containing 1C | 0.0472678 |
| AHR | aryl hydrocarbon receptor | 0.04546 |
| NAV2 | neuron navigator 2 | 0.0453158 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0434234 |
| ANXA2 | annexin A2 | 0.0430252 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0425624 |
| CENPF | centromere protein F, 350/400kDa | 0.042439 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0420587 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0411396 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0406342 |
| PDE10A | phosphodiesterase 10A | 0.0402858 |
| OGA | O-GlcNAcase | 0.0402138 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0397082 |
| MX1 | MX dynamin-like GTPase 1 | 0.0392172 |
| SYAP1 | synapse associated protein 1 | 0.0391312 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0388163 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0387359 |
| IL6ST | interleukin 6 signal transducer | 0.0383223 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0377774 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0377696 |
| NDRG1 | N-myc downstream regulated 1 | 0.0374416 |
| CCNL1 | cyclin L1 | 0.0370065 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.036987 |
| DUSP5 | dual specificity phosphatase 5 | 0.0365514 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0361006 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0359126 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0355108 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0353303 |
| TNS3 | tensin 3 | 0.0348053 |
| ARF4 | ADP-ribosylation factor 4 | 0.0347382 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0346519 |
| OSMR | oncostatin M receptor | 0.0335808 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.033526 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0335222 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0334346 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0327341 |
| LOXL2 | lysyl oxidase-like 2 | 0.0325484 |
| CDCP1 | CUB domain containing protein 1 | 0.0323002 |
| TGM2 | transglutaminase 2 | 0.0322299 |
| ANLN | anillin, actin binding protein | 0.0318049 |
| PLPP3 | phospholipid phosphatase 3 | 0.0313778 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0306291 |
| SFTPA2 | surfactant protein A2 | 0.0305017 |
| SDC4 | syndecan 4 | 0.0304556 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0302185 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0301947 |
| LDHA | lactate dehydrogenase A | 0.030034 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0299734 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.029811 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0287196 |
| SH3BP4 | SH3-domain binding protein 4 | 0.0286463 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0285524 |
| LRRC7 | leucine rich repeat containing 7 | 0.0285217 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0284356 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0279807 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0279763 |
| KLF6 | Kruppel-like factor 6 | 0.0277207 |
| TXNRD1 | thioredoxin reductase 1 | 0.0276744 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0276421 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.162084 |
| HMGA2 | high mobility group AT-hook 2 | -0.133597 |
| FRMD4A | FERM domain containing 4A | -0.11448 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.107675 |
| IER3 | immediate early response 3 | -0.106259 |
| CDH13 | cadherin 13 | -0.105855 |
| GLIS3 | GLIS family zinc finger 3 | -0.0960777 |
| HLA-B | major histocompatibility complex, class I, B | -0.08928 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0876943 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0858114 |
| INTS6 | integrator complex subunit 6 | -0.0758741 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0731901 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.069765 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0697004 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0689223 |
| TMSB10 | thymosin beta 10 | -0.0617702 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0604347 |
| TMEM132D | transmembrane protein 132D | -0.0574038 |
| FTL | ferritin, light polypeptide | -0.0573591 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0565171 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0463421 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0438027 |
| TMSB4X | thymosin beta 4, X-linked | -0.0427017 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0421042 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0402077 |
| CANX | calnexin | -0.0392197 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0388312 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0386742 |
| RPS24 | ribosomal protein S24 | -0.0386321 |
| EGFR | epidermal growth factor receptor | -0.0384917 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.038211 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0379928 |
| SQSTM1 | sequestosome 1 | -0.0369874 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0364908 |
| DIAPH2 | diaphanous-related formin 2 | -0.036432 |
| HDAC9 | histone deacetylase 9 | -0.0356827 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0336276 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0328633 |
| COL5A1 | collagen, type V, alpha 1 | -0.0328499 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.032764 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0327307 |
| RPL23 | ribosomal protein L23 | -0.0326122 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0325534 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0324048 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0314325 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0309452 |
| RPS6 | ribosomal protein S6 | -0.0308121 |
| CALR | calreticulin | -0.0307455 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0300659 |
| RPL35A | ribosomal protein L35a | -0.0299852 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0296134 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0291304 |
| RPLP2 | ribosomal protein, large, P2 | -0.0288999 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0284347 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0279251 |
| CTSD | cathepsin D | -0.0276021 |
| HLA-A | major histocompatibility complex, class I, A | -0.0271651 |
| MORF4L2 | mortality factor 4 like 2 | -0.0269061 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0268836 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0267975 |
| RPL37A | ribosomal protein L37a | -0.0260472 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0254176 |
| CLMP | CXADR-like membrane protein | -0.0251251 |
| PLIN2 | perilipin 2 | -0.0241202 |
| ACTG1 | actin gamma 1 | -0.0239892 |
| MED13 | mediator complex subunit 13 | -0.0238077 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0234877 |
| RPL9 | ribosomal protein L9 | -0.0234765 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.023434 |
| DTNA | dystrobrevin, alpha | -0.0231569 |
| NRN1 | neuritin 1 | -0.0231346 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0228069 |
| TBCA | tubulin folding cofactor A | -0.0227134 |
| RPS8 | ribosomal protein S8 | -0.0226678 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.022117 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.022037 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0218986 |
| CUX1 | cut-like homeobox 1 | -0.0218288 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0217403 |
| DENND2A | DENN/MADD domain containing 2A | -0.0217335 |
| RPS21 | ribosomal protein S21 | -0.0216577 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0213957 |
| TULP4 | tubby like protein 4 | -0.0212517 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0211114 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0209304 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0206487 |
| RPLP1 | ribosomal protein, large, P1 | -0.020263 |
| LSAMP | limbic system-associated membrane protein | -0.020242 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0199644 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | -0.0199593 |
| FMNL2 | formin-like 2 | -0.0197733 |
| CTBP2 | C-terminal binding protein 2 | -0.0197107 |
| PTMA | prothymosin, alpha | -0.019561 |
| CDK13 | cyclin-dependent kinase 13 | -0.0194954 |
| RPS23 | ribosomal protein S23 | -0.0194556 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0193532 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0193451 |
| DUSP10 | dual specificity phosphatase 10 | -0.0193241 |
| GNAS | GNAS complex locus | -0.0192009 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0191681 |
