Tirabrutinib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.214996
MYH9 myosin, heavy chain 9, non-muscle 0.0570376
NDRG1 N-myc downstream regulated 1 0.0491083
CD44 CD44 molecule (Indian blood group) 0.0488141
PRELID2 PRELI domain containing 2 0.0458713
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0432574
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0431349
CADM1 cell adhesion molecule 1 0.0402146
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0396249
ATP13A3 ATPase type 13A3 0.0385049
SOD2 superoxide dismutase 2, mitochondrial 0.0362943
ELL2 elongation factor, RNA polymerase II, 2 0.0361673
UBA6 ubiquitin-like modifier activating enzyme 6 0.035709
FNDC3B fibronectin type III domain containing 3B 0.0349695
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0342008
SMAD3 SMAD family member 3 0.0330598
ESYT2 extended synaptotagmin-like protein 2 0.0329374
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0324418
MACF1 microtubule-actin crosslinking factor 1 0.0323469
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0322994
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0319175
ARRDC3 arrestin domain containing 3 0.0318494
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0315531
MSN moesin 0.0313823
KMT2E lysine (K)-specific methyltransferase 2E 0.0297973
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0294862
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0289114
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0285714
MBD5 methyl-CpG binding domain protein 5 0.0281218
FMNL2 formin-like 2 0.0274792
LOX lysyl oxidase 0.0273654
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0266225
RNF145 ring finger protein 145 0.0264325
FTH1 ferritin, heavy polypeptide 1 0.0263766
CD109 CD109 molecule 0.0261994
NAV2 neuron navigator 2 0.0255644
ZMIZ1 zinc finger, MIZ-type containing 1 0.0248526
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0241931
RUNX1 runt-related transcription factor 1 0.0239279
PDE10A phosphodiesterase 10A 0.0232314
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0229551
ARHGAP35 Rho GTPase activating protein 35 0.0228912
FAM13A family with sequence similarity 13, member A 0.0212088
CAST calpastatin 0.0211814
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.021111
L1CAM L1 cell adhesion molecule 0.020856
NCOR2 nuclear receptor corepressor 2 0.0207466
CCDC14 coiled-coil domain containing 14 0.0206515
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0205647
FEM1C fem-1 homolog c (C. elegans) 0.0205641
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0204786
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0203127
CYLD cylindromatosis (turban tumor syndrome) 0.0201384
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0200248
SDK1 sidekick cell adhesion molecule 1 0.0199713
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0197805
SAMD4A sterile alpha motif domain containing 4A 0.0196142
NRXN3 neurexin 3 0.0195278
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0193837
EFNA5 ephrin-A5 0.0193153
CDK6 cyclin-dependent kinase 6 0.0192242
BIRC2 baculoviral IAP repeat containing 2 0.0191693
HPS3 Hermansky-Pudlak syndrome 3 0.0189928
C1D C1D nuclear receptor corepressor 0.0187161
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0183699
SCFD1 sec1 family domain containing 1 0.0183349
UBE2O ubiquitin-conjugating enzyme E2O 0.018317
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0182003
BCLAF1 BCL2-associated transcription factor 1 0.0181738
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0180953
YTHDC1 YTH domain containing 1 0.017962
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0179537
BIRC3 baculoviral IAP repeat containing 3 0.0175864
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0174153
FRMD6 FERM domain containing 6 0.0172742
MATR3 matrin 3 0.0171239
CORO1C coronin, actin binding protein, 1C 0.0170297
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0169242
GPSM2 G-protein signaling modulator 2 0.0167593
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.016534
KAZN kazrin, periplakin interacting protein 0.0164549
ARF6 ADP-ribosylation factor 6 0.0163625
SHB Src homology 2 domain containing adaptor protein B 0.016289
ITCH itchy E3 ubiquitin protein ligase 0.0162355
DIAPH3 diaphanous-related formin 3 0.0160283
IL1R1 interleukin 1 receptor, type I 0.0159589
APLP2 amyloid beta (A4) precursor-like protein 2 0.0158869
RNASE3 ribonuclease, RNase A family, 3 0.0158238
MED15 mediator complex subunit 15 0.0157362
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0157047
CNOT1 CCR4-NOT transcription complex, subunit 1 0.015494
COL4A1 collagen, type IV, alpha 1 0.0154371
RLIM ring finger protein, LIM domain interacting 0.015429
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0153641
SEPTIN9 septin 9 0.0153588
PIAS2 protein inhibitor of activated STAT, 2 0.0153074
SNX13 sorting nexin 13 0.0153011
MAML2 mastermind-like 2 (Drosophila) 0.0152328
PCBP2 poly(rC) binding protein 2 0.0152
RNF111 ring finger protein 111 0.0150449

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.223701
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.208179
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.186459
VIM vimentin -0.18342
MT2A metallothionein 2A -0.171383
TMSB10 thymosin beta 10 -0.161484
HLA-B major histocompatibility complex, class I, B -0.148926
TIMP3 TIMP metallopeptidase inhibitor 3 -0.117269
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.107235
B2M beta-2-microglobulin -0.0965212
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.093972
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0863484
PTMA prothymosin, alpha -0.0826287
FTL ferritin, light polypeptide -0.0822071
ACTG1 actin gamma 1 -0.064016
TGFBI transforming growth factor, beta-induced, 68kDa -0.0595215
TPT1 tumor protein, translationally-controlled 1 -0.0581744
CALR calreticulin -0.0560558
HLA-C major histocompatibility complex, class I, C -0.0540505
MT1X metallothionein 1X -0.052904
RPL34 ribosomal protein L34 -0.050813
CALU calumenin -0.0501649
ENO1 enolase 1, (alpha) -0.0493946
F3 coagulation factor III (thromboplastin, tissue factor) -0.047074
TPM4 tropomyosin 4 -0.0466603
PRSS23 protease, serine, 23 -0.0461996
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0456716
EIF1 eukaryotic translation initiation factor 1 -0.0452553
CAVIN1 caveolae associated protein 1 -0.0437185
RPL35A ribosomal protein L35a -0.0415933
COL1A1 collagen, type I, alpha 1 -0.040038
RPS8 ribosomal protein S8 -0.0394619
CALD1 caldesmon 1 -0.0388604
S100A6 S100 calcium binding protein A6 -0.0383448
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0380932
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0372945
FN1 fibronectin 1 -0.0365581
RRBP1 ribosome binding protein 1 -0.0364115
GLIS3 GLIS family zinc finger 3 -0.0363425
TMSB4X thymosin beta 4, X-linked -0.0359269
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0346313
ZMYND8 zinc finger, MYND-type containing 8 -0.034578
EXT1 exostosin glycosyltransferase 1 -0.0339444
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.033849
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0336864
CCNI cyclin I -0.0334071
RPS6 ribosomal protein S6 -0.0333749
GARS1 glycyl-tRNA synthetase 1 -0.0329036
WSB1 WD repeat and SOCS box containing 1 -0.0327901
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0327329
COL6A2 collagen, type VI, alpha 2 -0.0320196
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0316626
RPLP1 ribosomal protein, large, P1 -0.0316604
RPS14 ribosomal protein S14 -0.0314137
S100A9 S100 calcium binding protein A9 -0.0311895
COPB1 coatomer protein complex, subunit beta 1 -0.0303326
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0302929
STC1 stanniocalcin 1 -0.0301453
NAMPT nicotinamide phosphoribosyltransferase -0.030093
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0297649
TNS3 tensin 3 -0.0294389
S100A10 S100 calcium binding protein A10 -0.0290326
HDLBP high density lipoprotein binding protein -0.0290012
CDK13 cyclin-dependent kinase 13 -0.0287771
SEC24D SEC24 family member D -0.0286678
SEPTIN7 septin 7 -0.0283523
COL1A2 collagen, type I, alpha 2 -0.0282395
CDH13 cadherin 13 -0.0281736
AHNAK AHNAK nucleoprotein -0.0281379
LOXL2 lysyl oxidase-like 2 -0.027791
RPL11 ribosomal protein L11 -0.0277517
PDIA4 protein disulfide isomerase family A, member 4 -0.0267131
RPS27A ribosomal protein S27a -0.0266848
RPL28 ribosomal protein L28 -0.0264138
SEC61G Sec61 gamma subunit -0.0263292
HIP1 huntingtin interacting protein 1 -0.0259582
RPL37 ribosomal protein L37 -0.0257325
GNAS GNAS complex locus -0.0256013
COL6A1 collagen, type VI, alpha 1 -0.0255215
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0254583
PKM pyruvate kinase, muscle -0.0254073
HM13 histocompatibility (minor) 13 -0.0252676
RAI14 retinoic acid induced 14 -0.0251687
BZW1 basic leucine zipper and W2 domains 1 -0.0249998
RPLP0 ribosomal protein, large, P0 -0.0249066
CANX calnexin -0.0246299
RPLP2 ribosomal protein, large, P2 -0.0245728
RACK1 receptor for activated C kinase 1 -0.0243836
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0238985
RTN4 reticulon 4 -0.0238361
RPL8 ribosomal protein L8 -0.0237816
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0234795
EGFR epidermal growth factor receptor -0.0232965
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0229838
HLA-A major histocompatibility complex, class I, A -0.0228488
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0224886
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0224773
GCC2 GRIP and coiled-coil domain containing 2 -0.0224397
NIPBL Nipped-B homolog (Drosophila) -0.0224167
IARS1 isoleucyl-tRNA synthetase 1 -0.0223885