| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.271756 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.153707 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.142445 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.138392 |
| ASPH | aspartate beta-hydroxylase | 0.113838 |
| FNDC3B | fibronectin type III domain containing 3B | 0.112906 |
| CENPF | centromere protein F, 350/400kDa | 0.103035 |
| OSMR | oncostatin M receptor | 0.102275 |
| NRP1 | neuropilin 1 | 0.0995547 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0904329 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0902883 |
| TXNIP | thioredoxin interacting protein | 0.0876097 |
| FN1 | fibronectin 1 | 0.0863798 |
| GLIS3 | GLIS family zinc finger 3 | 0.0861083 |
| AHR | aryl hydrocarbon receptor | 0.0825491 |
| DST | dystonin | 0.0768339 |
| ITGA1 | integrin, alpha 1 | 0.0767285 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0678106 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0676232 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0656161 |
| CD44 | CD44 molecule (Indian blood group) | 0.0655555 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0636444 |
| ETV6 | ets variant 6 | 0.0627891 |
| NDRG1 | N-myc downstream regulated 1 | 0.0617696 |
| SMAD3 | SMAD family member 3 | 0.0586418 |
| PRELID2 | PRELI domain containing 2 | 0.0583047 |
| EXT1 | exostosin glycosyltransferase 1 | 0.057997 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0568322 |
| SMOX | spermine oxidase | 0.0562932 |
| DOCK5 | dedicator of cytokinesis 5 | 0.054565 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0538842 |
| TXNRD1 | thioredoxin reductase 1 | 0.0536398 |
| MKI67 | marker of proliferation Ki-67 | 0.0524529 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0517972 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0515357 |
| TMEM156 | transmembrane protein 156 | 0.0514372 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0514028 |
| EFNA5 | ephrin-A5 | 0.051162 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0506395 |
| VEGFC | vascular endothelial growth factor C | 0.0495651 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0487502 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0483196 |
| ZNF292 | zinc finger protein 292 | 0.0478628 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0468796 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0466881 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0466255 |
| TPR | translocated promoter region, nuclear basket protein | 0.0464152 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0462336 |
| CAB39 | calcium binding protein 39 | 0.0458632 |
| PTK2 | protein tyrosine kinase 2 | 0.0447852 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0441504 |
| PELO | pelota homolog (Drosophila) | 0.0439582 |
| ADD3 | adducin 3 (gamma) | 0.0438569 |
| SMYD3 | SET and MYND domain containing 3 | 0.0435761 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0434466 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0433611 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0415671 |
| FNBP1 | formin binding protein 1 | 0.0414315 |
| RUNX2 | runt-related transcription factor 2 | 0.0409095 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0405184 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0401266 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0398654 |
| MT2A | metallothionein 2A | 0.0397731 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0393825 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.038759 |
| FOXP1 | forkhead box P1 | 0.0382422 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0374476 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0374092 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0371859 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0371783 |
| ITGB5 | integrin, beta 5 | 0.036953 |
| SLTM | SAFB-like, transcription modulator | 0.0368771 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0368355 |
| SVIL | supervillin | 0.0365208 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0363419 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0362608 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0359208 |
| SYNJ2 | synaptojanin 2 | 0.0358235 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0355102 |
| TOP1 | topoisomerase (DNA) I | 0.035305 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0351167 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0349418 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0347893 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.034525 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0340803 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0340006 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.033778 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0336882 |
| IL6ST | interleukin 6 signal transducer | 0.0326053 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0324606 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0322781 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0321669 |
| RNF24 | ring finger protein 24 | 0.0320048 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0319729 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0319012 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0317754 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0312232 |
| LAMA4 | laminin, alpha 4 | 0.0311507 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.03104 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.030969 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.210412 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.122245 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.117282 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.111852 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0896267 |
| INTS6 | integrator complex subunit 6 | -0.07294 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.069748 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0693375 |
| SQSTM1 | sequestosome 1 | -0.058198 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0549381 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0506426 |
| HLA-B | major histocompatibility complex, class I, B | -0.0494213 |
| TMSB10 | thymosin beta 10 | -0.0488242 |
| AEBP2 | AE binding protein 2 | -0.0488013 |
| CADM1 | cell adhesion molecule 1 | -0.043406 |
| TMSB4X | thymosin beta 4, X-linked | -0.0431923 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0415701 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0409518 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0383226 |
| ACTG1 | actin gamma 1 | -0.0368875 |
| PALLD | palladin, cytoskeletal associated protein | -0.0358828 |
| LRRC23 | leucine rich repeat containing 23 | -0.0357547 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0352837 |
| S100A6 | S100 calcium binding protein A6 | -0.0332091 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0314778 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0313258 |
| CANX | calnexin | -0.0310167 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0306325 |
| TENM4 | teneurin transmembrane protein 4 | -0.0296184 |
| STC2 | stanniocalcin 2 | -0.029016 |
| PTMA | prothymosin, alpha | -0.0284265 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0270008 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0263729 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.026055 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0256133 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0252231 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0247823 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0244026 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0242694 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0241954 |
| IER3 | immediate early response 3 | -0.024022 |
| FBN1 | fibrillin 1 | -0.0237803 |
| TUFT1 | tuftelin 1 | -0.0235615 |
| POU2F2 | POU class 2 homeobox 2 | -0.0235458 |
| VCL | vinculin | -0.0232863 |
| CCDC138 | coiled-coil domain containing 138 | -0.0232857 |
| RPS24 | ribosomal protein S24 | -0.0229765 |
| MMP13 | matrix metallopeptidase 13 | -0.0228397 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0227753 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.022273 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0220835 |
| LAMB3 | laminin, beta 3 | -0.0216888 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0213177 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0210648 |
| UBAP2 | ubiquitin associated protein 2 | -0.0210632 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.020804 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0207562 |
| S100A10 | S100 calcium binding protein A10 | -0.0198659 |
| RTN3 | reticulon 3 | -0.0197466 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0197207 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0193967 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0193192 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.019295 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.018315 |
| LMNA | lamin A/C | -0.0182737 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0181891 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0181646 |
| FMNL2 | formin-like 2 | -0.0180102 |
| CTSD | cathepsin D | -0.0179926 |
| HMGA2 | high mobility group AT-hook 2 | -0.0179505 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0178156 |
| CLIC4 | chloride intracellular channel 4 | -0.0177946 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0177047 |
| UBC | ubiquitin C | -0.0176722 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0175349 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0175046 |
| MTSS1 | metastasis suppressor 1 | -0.0174496 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0174096 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0172437 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0166019 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0162819 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0162799 |
| JUN | jun proto-oncogene | -0.016142 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0155545 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.015359 |
| DUSP6 | dual specificity phosphatase 6 | -0.0151163 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0150727 |
| NABP1 | nucleic acid binding protein 1 | -0.015022 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0150188 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0149392 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0148496 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0148483 |
| CTBP2 | C-terminal binding protein 2 | -0.0148351 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.014629 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0145126 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0143592 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0141728 |
| TTC23L | tetratricopeptide repeat domain 23-like | -0.014111 |
| FBXO11 | F-box protein 11 | -0.014038 |
| NPAS1 | neuronal PAS domain protein 1 | -0.0139778 |
