| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites. (Chemical Entities of Biological Interest Ontology, CHEBI_63629) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5487 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Tizanidine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NEK4 | NIMA-related kinase 4 | 1.32 |
| SASH1 | SAM and SH3 domain containing 1 | 0.92 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.66 |
| CMC1 | C-x(9)-C motif containing 1 | 0.58 |
| STRIP2 | striatin interacting protein 2 | 0.55 |
| ZNF414 | zinc finger protein 414 | 0.5 |
| NCKAP1L | NCK-associated protein 1-like | 0.5 |
| FOXC1 | forkhead box C1 | 0.48 |
| RCOR2 | REST corepressor 2 | 0.46 |
| EPHB3 | EPH receptor B3 | 0.45 |
| SUSD1 | sushi domain containing 1 | 0.44 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.43 |
| UBE2F | ubiquitin-conjugating enzyme E2F (putative) | 0.43 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.42 |
| ZNF264 | zinc finger protein 264 | 0.42 |
| B2M | beta-2-microglobulin | 0.42 |
| TIFA | TRAF-interacting protein with forkhead-associated domain | 0.41 |
| DTNBP1 | dystrobrevin binding protein 1 | 0.4 |
| ENO1 | enolase 1, (alpha) | 0.4 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.4 |
| ACTBL2 | actin, beta-like 2 | 0.4 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.39 |
| CD81 | CD81 molecule | 0.39 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.39 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.38 |
| OTUD7A | OTU deubiquitinase 7A | 0.38 |
| COBL | cordon-bleu WH2 repeat protein | 0.37 |
| RPS25 | ribosomal protein S25 | 0.37 |
| PROSER1 | proline and serine rich 1 | 0.37 |
| USP30 | ubiquitin specific peptidase 30 | 0.37 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.37 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.37 |
| ARSB | arylsulfatase B | 0.36 |
| CCDC117 | coiled-coil domain containing 117 | 0.36 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 0.36 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.36 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.36 |
| ZNF28 | zinc finger protein 28 | 0.35 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.35 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.34 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.34 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.34 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | 0.33 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | 0.33 |
| SET | SET nuclear proto-oncogene | 0.33 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.33 |
| RGP1 | RGP1 retrograde golgi transport homolog (S. cerevisiae) | 0.32 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.32 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.32 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | 0.32 |
| ELOC | elongin C | 0.32 |
| ZBTB21 | zinc finger and BTB domain containing 21 | 0.32 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.32 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | 0.32 |
| DCLRE1B | DNA cross-link repair 1B | 0.32 |
| AHI1 | Abelson helper integration site 1 | 0.32 |
| H2AFX | H2A histone family, member X | 0.32 |
| ZNF114 | zinc finger protein 114 | 0.32 |
| TET3 | tet methylcytosine dioxygenase 3 | 0.32 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.32 |
| SPATA20 | spermatogenesis associated 20 | 0.31 |
| ANKRD26 | ankyrin repeat domain 26 | 0.31 |
| NUBPL | nucleotide binding protein-like | 0.31 |
| C2ORF76 | chromosome 2 open reading frame 76 | 0.31 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.31 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.3 |
| ASTE1 | asteroid homolog 1 (Drosophila) | 0.3 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | 0.3 |
| CCS | copper chaperone for superoxide dismutase | 0.3 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.3 |
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 0.29 |
| TRIM62 | tripartite motif containing 62 | 0.29 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.29 |
| C19ORF47 | chromosome 19 open reading frame 47 | 0.29 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.29 |
| ZSWIM9 | zinc finger SWIM-type containing 9 | 0.28 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.28 |
| CENPP | centromere protein P | 0.28 |
| TRIM37 | tripartite motif containing 37 | 0.28 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.28 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.28 |
| KIAA1107 | KIAA1107 | 0.28 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.28 |
| METTL15 | methyltransferase like 15 | 0.28 |
| YBX3 | Y box binding protein 3 | 0.27 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.27 |
| TMEM131L | transmembrane 131 like | 0.27 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.27 |
| TBC1D22A | TBC1 domain family, member 22A | 0.27 |
| TTC7B | tetratricopeptide repeat domain 7B | 0.27 |
| DEPDC1 | DEP domain containing 1 | 0.27 |
| POTEE | POTE ankyrin domain family, member E | 0.27 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | 0.27 |
| S100A6 | S100 calcium binding protein A6 | 0.26 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.26 |
| WDR60 | WD repeat domain 60 | 0.26 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.26 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | 0.26 |
| ZNF431 | zinc finger protein 431 | 0.26 |
| ARG2 | arginase 2 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPHP3 | nephronophthisis 3 (adolescent) | -2.76 |
| ZBTB47 | zinc finger and BTB domain containing 47 | -0.74 |
| MFSD5 | major facilitator superfamily domain containing 5 | -0.64 |
| VASN | vasorin | -0.62 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -0.62 |
| PLEC | plectin | -0.61 |
| PLXNB1 | plexin B1 | -0.58 |
| GRAMD2B | GRAM domain containing 2B | -0.56 |
| DEPDC7 | DEP domain containing 7 | -0.54 |
| CUL9 | cullin 9 | -0.52 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.52 |
| NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D | -0.51 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.51 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.49 |
| RAB20 | RAB20, member RAS oncogene family | -0.48 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.48 |
| HMOX1 | heme oxygenase 1 | -0.44 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.43 |
| TPCN1 | two pore segment channel 1 | -0.42 |
| LSM7 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.42 |
| ZNF669 | zinc finger protein 669 | -0.41 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | -0.41 |
| BOK | BCL2-related ovarian killer | -0.4 |
| ANO10 | anoctamin 10 | -0.4 |
| ZNF646 | zinc finger protein 646 | -0.39 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.39 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.38 |
| LYST | lysosomal trafficking regulator | -0.37 |
| STK17B | serine/threonine kinase 17b | -0.36 |
| KLHL2 | kelch-like family member 2 | -0.36 |
| PHETA1 | PH domain containing endocytic trafficking adaptor 1 | -0.35 |
| TMEM160 | transmembrane protein 160 | -0.35 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.35 |
| LSM12 | LSM12 homolog (S. cerevisiae) | -0.35 |
| CAPN15 | calpain 15 | -0.35 |
| SLC9A6 | solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 | -0.35 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -0.34 |
| LETMD1 | LETM1 domain containing 1 | -0.34 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | -0.34 |
| YAP1 | Yes-associated protein 1 | -0.33 |
| DUSP4 | dual specificity phosphatase 4 | -0.33 |
| TM2D3 | TM2 domain containing 3 | -0.32 |
| NUCB1 | nucleobindin 1 | -0.32 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -0.32 |
| RNF7 | ring finger protein 7 | -0.32 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.32 |
| MSL3 | male-specific lethal 3 homolog (Drosophila) | -0.32 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | -0.31 |
| ZNF587 | zinc finger protein 587 | -0.31 |
| VIM | vimentin | -0.31 |
| CEP290 | centrosomal protein 290kDa | -0.31 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -0.3 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.3 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.29 |
| TMEM184A | transmembrane protein 184A | -0.29 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.29 |
| NLRX1 | NLR family member X1 | -0.29 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | -0.29 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.29 |
| CKM | creatine kinase, muscle | -0.28 |
| KCTD13 | potassium channel tetramerization domain containing 13 | -0.28 |
| TSC22D2 | TSC22 domain family, member 2 | -0.28 |
| ACD | adrenocortical dysplasia homolog (mouse) | -0.28 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | -0.27 |
| HSH2D | hematopoietic SH2 domain containing | -0.27 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.27 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.27 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | -0.27 |
| PEX19 | peroxisomal biogenesis factor 19 | -0.27 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.27 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.27 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | -0.26 |
| ABITRAM | actin binding transcription modulator | -0.26 |
| UBQLN1 | ubiquilin 1 | -0.26 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.26 |
| ORC3 | origin recognition complex, subunit 3 | -0.26 |
| GSTO2 | glutathione S-transferase omega 2 | -0.26 |
| FYTTD1 | forty-two-three domain containing 1 | -0.25 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.25 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -0.25 |
| ZFP36 | ZFP36 ring finger protein | -0.25 |
| TCHP | trichoplein, keratin filament binding | -0.25 |
| DIXDC1 | DIX domain containing 1 | -0.25 |
| ZNF552 | zinc finger protein 552 | -0.25 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.24 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.24 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.24 |
| ZNF428 | zinc finger protein 428 | -0.24 |
| MKRN1 | makorin ring finger protein 1 | -0.24 |
| DTX2 | deltex 2, E3 ubiquitin ligase | -0.24 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.24 |
| MANEA | mannosidase, endo-alpha | -0.24 |
| ABAT | 4-aminobutyrate aminotransferase | -0.23 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.23 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.23 |
| E2F3 | E2F transcription factor 3 | -0.23 |
| CSNK1D | casein kinase 1, delta | -0.23 |
| ITGA6 | integrin, alpha 6 | -0.23 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | -0.23 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -0.23 |
