Tofacitinib (citrate)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib (citrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.180906
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.145226
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.103999
CDH13 cadherin 13 0.101485
CALR calreticulin 0.0972116
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0845432
FTH1 ferritin, heavy polypeptide 1 0.0792375
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0746753
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0707778
BHLHE40 basic helix-loop-helix family, member e40 0.0693933
VIM vimentin 0.0652605
EEF2 eukaryotic translation elongation factor 2 0.0650611
PBX3 pre-B-cell leukemia homeobox 3 0.0611486
MYH9 myosin, heavy chain 9, non-muscle 0.060349
ANKRD11 ankyrin repeat domain 11 0.0603222
TRIO trio Rho guanine nucleotide exchange factor 0.0549533
AHNAK AHNAK nucleoprotein 0.0545563
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0540859
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0537387
SRRM2 serine/arginine repetitive matrix 2 0.052968
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0527699
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0506449
CANX calnexin 0.0501758
VEGFA vascular endothelial growth factor A 0.0475262
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0474817
SLC39A11 solute carrier family 39, member 11 0.0459118
GOLGA4 golgin A4 0.0448381
HDAC9 histone deacetylase 9 0.0443411
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0430033
AHNAK2 AHNAK nucleoprotein 2 0.0424138
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0418871
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0410563
CD44 CD44 molecule (Indian blood group) 0.0402888
FLNA filamin A, alpha 0.0395791
EGFR epidermal growth factor receptor 0.0387276
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0383888
COL5A1 collagen, type V, alpha 1 0.0380866
COPA coatomer protein complex, subunit alpha 0.0380849
CD109 CD109 molecule 0.0373206
C1D C1D nuclear receptor corepressor 0.0348702
RHOA ras homolog family member A 0.0344454
TPM3 tropomyosin 3 0.0339427
AKAP12 A kinase (PRKA) anchor protein 12 0.0321518
CALU calumenin 0.0313269
AKAP9 A kinase (PRKA) anchor protein 9 0.0311006
MSN moesin 0.0307475
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0305472
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0305323
ENO1 enolase 1, (alpha) 0.0300828
NCOR2 nuclear receptor corepressor 2 0.0300678
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0294568
LOXL2 lysyl oxidase-like 2 0.0294484
TIMP2 TIMP metallopeptidase inhibitor 2 0.0288931
SMYD3 SET and MYND domain containing 3 0.0288314
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0285383
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.028361
ARF4 ADP-ribosylation factor 4 0.0281862
SPIRE1 spire-type actin nucleation factor 1 0.0276371
TPM4 tropomyosin 4 0.0276154
DST dystonin 0.027555
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0268839
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0263795
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0258152
BCL2L1 BCL2-like 1 0.0255994
GOLGB1 golgin B1 0.0254467
PDIA6 protein disulfide isomerase family A, member 6 0.0249914
AXL AXL receptor tyrosine kinase 0.0249627
RASAL2 RAS protein activator like 2 0.0244685
PDLIM5 PDZ and LIM domain 5 0.0244471
MACF1 microtubule-actin crosslinking factor 1 0.0241882
DOCK5 dedicator of cytokinesis 5 0.0241852
TTC3 tetratricopeptide repeat domain 3 0.0234268
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0233712
DIAPH1 diaphanous-related formin 1 0.0233049
PEA15 phosphoprotein enriched in astrocytes 15 0.0232939
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0232287
MYADM myeloid-associated differentiation marker 0.0227633
E2F7 E2F transcription factor 7 0.0223174
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0221135
RPS6 ribosomal protein S6 0.0218879
SEC16A SEC16 homolog A (S. cerevisiae) 0.0218571
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0216146
IARS1 isoleucyl-tRNA synthetase 1 0.0213596
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.021132
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0210435
PLEC plectin 0.0203355
PRRC2C proline-rich coiled-coil 2C 0.0203312
GOLGA2 golgin A2 0.0202553
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0198731
CEP250 centrosomal protein 250kDa 0.0197109
CSTB cystatin B (stefin B) 0.0196406
PPARD peroxisome proliferator-activated receptor delta 0.0194874
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0194315
ZMIZ1 zinc finger, MIZ-type containing 1 0.0193124
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0191023
RND3 Rho family GTPase 3 0.0191008
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0190169
DSPP dentin sialophosphoprotein 0.0189439
BIRC6 baculoviral IAP repeat containing 6 0.0188643
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0188462

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.177978
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.135308
FBN1 fibrillin 1 -0.1311
LOX lysyl oxidase -0.1212
RSAD2 radical S-adenosyl methionine domain containing 2 -0.118213
STAT1 signal transducer and activator of transcription 1, 91kDa -0.109628
COL3A1 collagen, type III, alpha 1 -0.104139
MX2 MX dynamin-like GTPase 2 -0.103776
SAMD9 sterile alpha motif domain containing 9 -0.093681
COL1A2 collagen, type I, alpha 2 -0.0916522
COL5A2 collagen, type V, alpha 2 -0.0898602
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0849987
RIGI RNA sensor RIG-I -0.0828614
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0827763
PLAT plasminogen activator, tissue -0.0809907
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0787462
TMSB10 thymosin beta 10 -0.0752072
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0735219
IFI16 interferon, gamma-inducible protein 16 -0.0708999
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0663087
IFIH1 interferon induced with helicase C domain 1 -0.0634987
HLA-B major histocompatibility complex, class I, B -0.0630997
FNDC3B fibronectin type III domain containing 3B -0.0623905
IFITM1 interferon induced transmembrane protein 1 -0.0615216
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0598343
ABI3BP ABI family, member 3 (NESH) binding protein -0.0579538
FN1 fibronectin 1 -0.0578724
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0567794
THBS2 thrombospondin 2 -0.0560699
SLC38A1 solute carrier family 38, member 1 -0.0552196
MT2A metallothionein 2A -0.0550425
GPC6 glypican 6 -0.0544257
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0504203
IGFBP3 insulin-like growth factor binding protein 3 -0.0489267
RNF213 ring finger protein 213 -0.0488161
IFITM3 interferon induced transmembrane protein 3 -0.048215
SP100 SP100 nuclear antigen -0.0481253
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0469391
ADAR adenosine deaminase, RNA-specific -0.0441699
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0440219
PSD3 pleckstrin and Sec7 domain containing 3 -0.0424417
HLA-C major histocompatibility complex, class I, C -0.0414989
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0411258
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0409325
TDRD7 tudor domain containing 7 -0.0408598
ZBTB20 zinc finger and BTB domain containing 20 -0.0404639
DPYSL3 dihydropyrimidinase-like 3 -0.0400447
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0399894
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0398851
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0398561
COL8A1 collagen, type VIII, alpha 1 -0.039723
SOD2 superoxide dismutase 2, mitochondrial -0.039333
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0385939
SAMD9L sterile alpha motif domain containing 9-like -0.0384914
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0379201
MT1X metallothionein 1X -0.0375888
PLSCR1 phospholipid scramblase 1 -0.036885
S100A10 S100 calcium binding protein A10 -0.0358314
IFI6 interferon, alpha-inducible protein 6 -0.0357538
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0355359
SUCNR1 succinate receptor 1 -0.0347872
CD99 CD99 molecule -0.0346288
TAGLN2 transgelin 2 -0.0344863
AFAP1 actin filament associated protein 1 -0.0339279
NAV1 neuron navigator 1 -0.0333797
ZNFX1 zinc finger, NFX1-type containing 1 -0.0332261
STC1 stanniocalcin 1 -0.0331657
AUTS2 autism susceptibility candidate 2 -0.0331437
UBC ubiquitin C -0.0331176
WARS1 tryptophanyl-tRNA synthetase 1 -0.0327793
PRSS23 protease, serine, 23 -0.0322218
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0319433
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0315492
TRIM22 tripartite motif containing 22 -0.0313175
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.031097
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0309576
SVIL supervillin -0.0308919
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0308135
SP3 Sp3 transcription factor -0.0308009
ISG15 ISG15 ubiquitin-like modifier -0.030759
TMOD1 tropomodulin 1 -0.0306009
IFI44 interferon-induced protein 44 -0.0303134
S100A4 S100 calcium binding protein A4 -0.0299286
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0296685
PMP22 peripheral myelin protein 22 -0.029601
SPAG9 sperm associated antigen 9 -0.0295797
TRIM56 tripartite motif containing 56 -0.02923
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.029055
ZNF217 zinc finger protein 217 -0.0284984
IFI44L interferon-induced protein 44-like -0.0284206
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0283141
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0281464
SBF2 SET binding factor 2 -0.0281291
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0279021
PRKD3 protein kinase D3 -0.0276484
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0275902
OASL 2'-5'-oligoadenylate synthetase-like -0.0273395
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0273114
HLA-E major histocompatibility complex, class I, E -0.027196
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0269694