| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.182003 |
| AREG | amphiregulin | 0.174906 |
| JMJD1C | jumonji domain containing 1C | 0.116187 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0946877 |
| VMP1 | vacuole membrane protein 1 | 0.0894234 |
| FTL | ferritin, light polypeptide | 0.0732898 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0687636 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0682749 |
| ANXA1 | annexin A1 | 0.0675627 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.066574 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0663279 |
| NEBL | nebulette | 0.0616031 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0615882 |
| YAP1 | Yes-associated protein 1 | 0.0595631 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0579407 |
| RPL35A | ribosomal protein L35a | 0.0567278 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0540456 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0536273 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0513237 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0507399 |
| RTN4 | reticulon 4 | 0.0493192 |
| RRM2 | ribonucleotide reductase M2 | 0.0492947 |
| WWOX | WW domain containing oxidoreductase | 0.0456511 |
| EHBP1 | EH domain binding protein 1 | 0.0455662 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0454144 |
| TPM3 | tropomyosin 3 | 0.045331 |
| RPS6 | ribosomal protein S6 | 0.0439022 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0428937 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0428419 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0417494 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0402256 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0401046 |
| PRELID2 | PRELI domain containing 2 | 0.0399124 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0396323 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0391624 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0387404 |
| USP34 | ubiquitin specific peptidase 34 | 0.0378939 |
| SESN2 | sestrin 2 | 0.0377915 |
| CUX1 | cut-like homeobox 1 | 0.037771 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0376912 |
| TPI1 | triosephosphate isomerase 1 | 0.0369535 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0355617 |
| TMEM41B | transmembrane protein 41B | 0.035128 |
| NHSL1 | NHS-like 1 | 0.0350036 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0341266 |
| MMP12 | matrix metallopeptidase 12 | 0.0333108 |
| RHOA | ras homolog family member A | 0.0331622 |
| PRKCE | protein kinase C, epsilon | 0.0319431 |
| CCN2 | cellular communication network factor 2 | 0.0318061 |
| RPS19 | ribosomal protein S19 | 0.0315911 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0315111 |
| RPLP1 | ribosomal protein, large, P1 | 0.0313836 |
| PCDH9 | protocadherin 9 | 0.0313772 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0313713 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0313644 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0311871 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0307763 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0307139 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0306516 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0305143 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.0302175 |
| RPS8 | ribosomal protein S8 | 0.0301763 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0300132 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0299194 |
| USP53 | ubiquitin specific peptidase 53 | 0.0298114 |
| MYO1D | myosin ID | 0.0287713 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0286735 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0283658 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0282808 |
| PHF21A | PHD finger protein 21A | 0.0280865 |
| RPL11 | ribosomal protein L11 | 0.0275853 |
| ANK2 | ankyrin 2, neuronal | 0.0275307 |
| YBX3 | Y box binding protein 3 | 0.0273566 |
| MKI67 | marker of proliferation Ki-67 | 0.0272877 |
| IPO7 | importin 7 | 0.0271492 |
| EZR | ezrin | 0.027144 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0271087 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0270585 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0268975 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0267853 |
| ZNF638 | zinc finger protein 638 | 0.0266086 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0264308 |
| GCG | glucagon | 0.0264011 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0260407 |
| HELZ | helicase with zinc finger | 0.0260125 |
| RPS26 | ribosomal protein S26 | 0.0258761 |
| RPS27 | ribosomal protein S27 | 0.0258554 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0256507 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0253575 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0253291 |
| BRD2 | bromodomain containing 2 | 0.0253101 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0251689 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.025092 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0250193 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0249556 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0247593 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0246524 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0243434 |
| ARF4 | ADP-ribosylation factor 4 | 0.0241312 |
| MAP1B | microtubule-associated protein 1B | 0.0239713 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC38A2 | solute carrier family 38, member 2 | -0.101666 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0985047 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0899736 |
| UBC | ubiquitin C | -0.084199 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0827866 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0817481 |
| RPS27A | ribosomal protein S27a | -0.076354 |
| TMSB10 | thymosin beta 10 | -0.0728889 |
| CLDN1 | claudin 1 | -0.0648453 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0641638 |
| ZNF804A | zinc finger protein 804A | -0.0559551 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0530585 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0526195 |
| AHNAK | AHNAK nucleoprotein | -0.052181 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0491105 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0467765 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0437162 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0428097 |
| TMEM123 | transmembrane protein 123 | -0.0395495 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.03927 |
| ECT2 | epithelial cell transforming 2 | -0.0381066 |
| CDK6 | cyclin-dependent kinase 6 | -0.037656 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0373426 |
| CXADR | coxsackie virus and adenovirus receptor | -0.036837 |
| LMO7 | LIM domain 7 | -0.0363715 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0363284 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0357108 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0357106 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0356098 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0345599 |
| TENM3 | teneurin transmembrane protein 3 | -0.0335318 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0334167 |
| PCDH7 | protocadherin 7 | -0.031734 |
| OXR1 | oxidation resistance 1 | -0.0313674 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0312213 |
| SYT1 | synaptotagmin I | -0.0305209 |
| GASK1B | golgi associated kinase 1B | -0.0293691 |
| ZNF217 | zinc finger protein 217 | -0.02906 |
| PCBP2 | poly(rC) binding protein 2 | -0.0289137 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0286042 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0276023 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.027484 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0272934 |
| RPS24 | ribosomal protein S24 | -0.0263855 |
| KLF6 | Kruppel-like factor 6 | -0.0261976 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.026134 |
| EDN1 | endothelin 1 | -0.0258192 |
| CENPE | centromere protein E, 312kDa | -0.0254448 |
| PLK2 | polo-like kinase 2 | -0.0252171 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0249251 |
| HSPA4 | heat shock 70kDa protein 4 | -0.0248699 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0248168 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0247952 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.024737 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0243668 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0240002 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0237375 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0234123 |
| MGAT4C | MGAT4 family, member C | -0.0231849 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0230863 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0228903 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0226957 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0225806 |
| CLPTM1L | CLPTM1-like | -0.0223695 |
| CCNG1 | cyclin G1 | -0.0223496 |
| USP15 | ubiquitin specific peptidase 15 | -0.0221943 |
| NRG1 | neuregulin 1 | -0.0221467 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.0220803 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0218975 |
| NLGN1 | neuroligin 1 | -0.0216951 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0216098 |
| WDR43 | WD repeat domain 43 | -0.0215947 |
| VCL | vinculin | -0.0212766 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0212187 |
| VIM | vimentin | -0.0212018 |
| ZFP91 | ZFP91 zinc finger protein | -0.0211781 |
| MPG | N-methylpurine-DNA glycosylase | -0.0209277 |
| DST | dystonin | -0.020802 |
| ETNK1 | ethanolamine kinase 1 | -0.0206831 |
| CMIP | c-Maf inducing protein | -0.0204438 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | -0.0203897 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0202593 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.020247 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0201531 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0201315 |
| AHR | aryl hydrocarbon receptor | -0.020126 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0201132 |
| NEK7 | NIMA-related kinase 7 | -0.0200045 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0199987 |
| ZNF519 | zinc finger protein 519 | -0.0199763 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0199539 |
| CCND1 | cyclin D1 | -0.0198756 |
| IPMK | inositol polyphosphate multikinase | -0.0198738 |
| ZNF207 | zinc finger protein 207 | -0.0198519 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0195979 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0195905 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0195829 |
| HDAC9 | histone deacetylase 9 | -0.0194949 |
| KLHL24 | kelch-like family member 24 | -0.0192597 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0190039 |
