| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.308007 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.215194 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.129985 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.104511 |
| VEGFA | vascular endothelial growth factor A | 0.0834494 |
| NDRG1 | N-myc downstream regulated 1 | 0.0675179 |
| NAV2 | neuron navigator 2 | 0.0671832 |
| CD44 | CD44 molecule (Indian blood group) | 0.0668638 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0617298 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0611686 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.060708 |
| B2M | beta-2-microglobulin | 0.0594464 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0549797 |
| TPM3 | tropomyosin 3 | 0.0520458 |
| FRMD4A | FERM domain containing 4A | 0.0512892 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0470662 |
| FTL | ferritin, light polypeptide | 0.0452029 |
| CALR | calreticulin | 0.045177 |
| RPS6 | ribosomal protein S6 | 0.0397638 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0383301 |
| LOXL2 | lysyl oxidase-like 2 | 0.0373461 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0372985 |
| GPC5 | glypican 5 | 0.0371267 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0368247 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0357987 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0357268 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0350857 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.033491 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.033421 |
| MSN | moesin | 0.0332991 |
| UBC | ubiquitin C | 0.0329376 |
| CANX | calnexin | 0.0328262 |
| PLEC | plectin | 0.0320834 |
| ANXA5 | annexin A5 | 0.0320503 |
| ADM | adrenomedullin | 0.0310714 |
| ATP13A3 | ATPase type 13A3 | 0.0299323 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0298532 |
| APP | amyloid beta (A4) precursor protein | 0.0296861 |
| ARRDC3 | arrestin domain containing 3 | 0.0296784 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0294886 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0293921 |
| OPTN | optineurin | 0.0291981 |
| ANXA1 | annexin A1 | 0.0290768 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0285419 |
| PLK2 | polo-like kinase 2 | 0.0278004 |
| TPR | translocated promoter region, nuclear basket protein | 0.0275276 |
| SFTPA2 | surfactant protein A2 | 0.0272088 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0266831 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0262334 |
| ANXA2 | annexin A2 | 0.0260328 |
| RPS2 | ribosomal protein S2 | 0.0257025 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0253294 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0253028 |
| RPL3 | ribosomal protein L3 | 0.0249978 |
| HDGF | hepatoma-derived growth factor | 0.0248651 |
| YBX1 | Y box binding protein 1 | 0.0248643 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.024847 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0248268 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0246563 |
| G0S2 | G0/G1 switch 2 | 0.0245878 |
| CALU | calumenin | 0.024338 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0242371 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0235387 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0235276 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.0230518 |
| CAVIN1 | caveolae associated protein 1 | 0.0229979 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0227664 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0222399 |
| VMP1 | vacuole membrane protein 1 | 0.0221008 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0217983 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0213973 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0213966 |
| RPL26 | ribosomal protein L26 | 0.0212355 |
| SET | SET nuclear proto-oncogene | 0.021148 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0208668 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0206411 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0204816 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0203566 |
| SEPTIN9 | septin 9 | 0.0200393 |
| PAX8 | paired box 8 | 0.019894 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0197738 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0196485 |
| RHOA | ras homolog family member A | 0.0196409 |
| AHNAK | AHNAK nucleoprotein | 0.0196187 |
| RPS27 | ribosomal protein S27 | 0.0196057 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0194931 |
| DSTN | destrin (actin depolymerizing factor) | 0.0194471 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0193336 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0193325 |
| RPS7 | ribosomal protein S7 | 0.0192651 |
| RPL7A | ribosomal protein L7a | 0.0188922 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0188568 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0188076 |
| VIRMA | vir like m6A methyltransferase associated | 0.0187953 |
| HSPA8 | heat shock 70kDa protein 8 | 0.018543 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0185386 |
| CKAP5 | cytoskeleton associated protein 5 | 0.018364 |
| CYRIA | CYFIP related Rac1 interactor A | 0.0183037 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0182848 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0182576 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.143053 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.133624 |
| ASPH | aspartate beta-hydroxylase | -0.126708 |
| EXT1 | exostosin glycosyltransferase 1 | -0.116094 |
| TMSB10 | thymosin beta 10 | -0.109205 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0998566 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0837517 |
| GLIS3 | GLIS family zinc finger 3 | -0.0833221 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0812693 |
| TXNRD1 | thioredoxin reductase 1 | -0.0784862 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0652202 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0634834 |
| KYNU | kynureninase | -0.0632523 |
| CP | ceruloplasmin (ferroxidase) | -0.0628921 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0625704 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0604679 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0599084 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0584153 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0510462 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0483396 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0481098 |
| RAI14 | retinoic acid induced 14 | -0.0459879 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0451286 |
| RNF213 | ring finger protein 213 | -0.0432442 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0432212 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0403211 |
| PTGR1 | prostaglandin reductase 1 | -0.0392017 |
| RRBP1 | ribosome binding protein 1 | -0.0379634 |
| IFI44L | interferon-induced protein 44-like | -0.0375761 |
| SMAD3 | SMAD family member 3 | -0.0371605 |
| TNS3 | tensin 3 | -0.0364858 |
| VCL | vinculin | -0.0360512 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0351254 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0349089 |
| STK17A | serine/threonine kinase 17a | -0.0338998 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0328931 |
| OSMR | oncostatin M receptor | -0.032092 |
| RIGI | RNA sensor RIG-I | -0.0318626 |
| HM13 | histocompatibility (minor) 13 | -0.0318027 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0314888 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0309479 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.030802 |
| RBM39 | RNA binding motif protein 39 | -0.0307142 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0304107 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0299881 |
| EHBP1 | EH domain binding protein 1 | -0.0298973 |
| HMGB1 | high mobility group box 1 | -0.0298771 |
| CMIP | c-Maf inducing protein | -0.0297212 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0296795 |
| PLSCR1 | phospholipid scramblase 1 | -0.0292252 |
| CTSD | cathepsin D | -0.029132 |
| RPS24 | ribosomal protein S24 | -0.0275195 |
| RTN4 | reticulon 4 | -0.0273777 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0271903 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0271121 |
| FUS | FUS RNA binding protein | -0.0270859 |
| TRIM56 | tripartite motif containing 56 | -0.0269465 |
| TUSC3 | tumor suppressor candidate 3 | -0.0267462 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0267028 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0266185 |
| NFIB | nuclear factor I/B | -0.0265561 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0265178 |
| CBX3 | chromobox homolog 3 | -0.0258485 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0257396 |
| ACTN4 | actinin, alpha 4 | -0.0257106 |
| NRP1 | neuropilin 1 | -0.0257071 |
| RRM2 | ribonucleotide reductase M2 | -0.0256089 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0255677 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0253466 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0253021 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0252342 |
| PALLD | palladin, cytoskeletal associated protein | -0.0250843 |
| SON | SON DNA binding protein | -0.0250263 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0250104 |
| TLE4 | transducin-like enhancer of split 4 | -0.0249977 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0249292 |
| ETV6 | ets variant 6 | -0.0247904 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0247038 |
| GNAS | GNAS complex locus | -0.0244441 |
| MX1 | MX dynamin-like GTPase 1 | -0.0241082 |
| DIAPH3 | diaphanous-related formin 3 | -0.024029 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0239769 |
| RPS4X | ribosomal protein S4, X-linked | -0.0238946 |
| RPS21 | ribosomal protein S21 | -0.0232329 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.023193 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.023147 |
| ZNF644 | zinc finger protein 644 | -0.0230216 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0229927 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0228686 |
| PFN1 | profilin 1 | -0.0228237 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.022667 |
| ANKRD10 | ankyrin repeat domain 10 | -0.022641 |
| NF1 | neurofibromin 1 | -0.0225958 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0224374 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0224291 |
| PTH2R | parathyroid hormone 2 receptor | -0.0223421 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0223259 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0222228 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0222075 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0221895 |
