| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.185867 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.137602 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.109436 |
| VIM | vimentin | 0.102421 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0840479 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0805701 |
| EGFR | epidermal growth factor receptor | 0.074655 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0682383 |
| AHNAK | AHNAK nucleoprotein | 0.0644863 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0565274 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.055474 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0552058 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0551361 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0540666 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0533509 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0525897 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0510689 |
| ANXA2 | annexin A2 | 0.0505113 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0504236 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0497519 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0479936 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0478612 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0459203 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0452411 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0451263 |
| TNS1 | tensin 1 | 0.0433904 |
| LMO7 | LIM domain 7 | 0.0432542 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0422994 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0422014 |
| PLEC | plectin | 0.0419598 |
| EFNA5 | ephrin-A5 | 0.0416205 |
| HMGA2 | high mobility group AT-hook 2 | 0.0415842 |
| SMYD3 | SET and MYND domain containing 3 | 0.0405175 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0401846 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0393012 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0389231 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0376189 |
| CCDC88A | coiled-coil domain containing 88A | 0.037465 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0368087 |
| RHCG | Rh family, C glycoprotein | 0.0362102 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0351656 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0349247 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0346872 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0343464 |
| USP47 | ubiquitin specific peptidase 47 | 0.0334437 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0323473 |
| INTS6 | integrator complex subunit 6 | 0.0314679 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0308709 |
| VEGFA | vascular endothelial growth factor A | 0.0307808 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0305311 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0300533 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0299271 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.0296652 |
| GOLGB1 | golgin B1 | 0.0296384 |
| C1D | C1D nuclear receptor corepressor | 0.0296312 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0295416 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.02939 |
| LAMC2 | laminin, gamma 2 | 0.0292472 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.029174 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0291387 |
| BPTF | bromodomain PHD finger transcription factor | 0.0280365 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0279796 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0270954 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0268221 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0263965 |
| MLPH | melanophilin | 0.0262298 |
| MCL1 | myeloid cell leukemia 1 | 0.0261542 |
| PRKCA | protein kinase C, alpha | 0.0259572 |
| RHOA | ras homolog family member A | 0.0259121 |
| CD44 | CD44 molecule (Indian blood group) | 0.0258561 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0258466 |
| CUX1 | cut-like homeobox 1 | 0.0257957 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0255919 |
| JMJD1C | jumonji domain containing 1C | 0.0255018 |
| FRMD6 | FERM domain containing 6 | 0.0247858 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.0245354 |
| BMP6 | bone morphogenetic protein 6 | 0.0243734 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0243443 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0242147 |
| MYO1D | myosin ID | 0.0239744 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0232881 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0232436 |
| ABR | active BCR-related | 0.0230562 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0224003 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0223428 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0223171 |
| FLNA | filamin A, alpha | 0.0220784 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0218995 |
| EZR | ezrin | 0.0217822 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0215408 |
| CAVIN1 | caveolae associated protein 1 | 0.0215406 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0209367 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0209037 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0207715 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0207521 |
| VMP1 | vacuole membrane protein 1 | 0.0204695 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0203415 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0203236 |
| MSI2 | musashi RNA-binding protein 2 | 0.0202183 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0201719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.204375 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.165531 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.131263 |
| KYNU | kynureninase | -0.124881 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.111486 |
| SMAD3 | SMAD family member 3 | -0.10341 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.103234 |
| FNDC3B | fibronectin type III domain containing 3B | -0.10165 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.099665 |
| TXNRD1 | thioredoxin reductase 1 | -0.0983027 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0954252 |
| PDE10A | phosphodiesterase 10A | -0.0919875 |
| MT2A | metallothionein 2A | -0.0851837 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0843141 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0802423 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.07569 |
| FTL | ferritin, light polypeptide | -0.073427 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0730028 |
| RIGI | RNA sensor RIG-I | -0.0717622 |
| SPAG9 | sperm associated antigen 9 | -0.0677841 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0674702 |
| RNF213 | ring finger protein 213 | -0.0668355 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0667741 |
| MT1X | metallothionein 1X | -0.0633892 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0633193 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0611014 |
| OSMR | oncostatin M receptor | -0.0607576 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0584115 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.056643 |
| ASPH | aspartate beta-hydroxylase | -0.0561201 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0557896 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0543235 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0540487 |
| USP3 | ubiquitin specific peptidase 3 | -0.0529766 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0528398 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0520098 |
| RPS2 | ribosomal protein S2 | -0.0496961 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0485972 |
| FAM107B | family with sequence similarity 107, member B | -0.0463127 |
| PLSCR1 | phospholipid scramblase 1 | -0.0460859 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0457745 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.045601 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0455772 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0445183 |
| EREG | epiregulin | -0.0435403 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0425415 |
| GPRIN3 | GPRIN family member 3 | -0.0425171 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0412906 |
| TMSB10 | thymosin beta 10 | -0.041225 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0412045 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0404115 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0402325 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0397754 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0391068 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0386059 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0385746 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0383987 |
| CMIP | c-Maf inducing protein | -0.0368766 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0367687 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0366324 |
| AOPEP | aminopeptidase O (putative) | -0.0360826 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0350994 |
| MYO1B | myosin IB | -0.034955 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0346859 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0338056 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0337821 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0332947 |
| YBX3 | Y box binding protein 3 | -0.0330278 |
| NRP1 | neuropilin 1 | -0.0327392 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0323697 |
| RPL19 | ribosomal protein L19 | -0.0320697 |
| PGK1 | phosphoglycerate kinase 1 | -0.0307184 |
| JAK1 | Janus kinase 1 | -0.030668 |
| KIAA1217 | KIAA1217 | -0.030543 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0305407 |
| UBC | ubiquitin C | -0.030251 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0300797 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0296729 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0293864 |
| TKT | transketolase | -0.0293355 |
| TGM2 | transglutaminase 2 | -0.0293247 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0292973 |
| RNF24 | ring finger protein 24 | -0.029026 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0288383 |
| CA8 | carbonic anhydrase VIII | -0.0287934 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0286974 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0285098 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0283684 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.0282345 |
| PMP22 | peripheral myelin protein 22 | -0.0275118 |
| ANLN | anillin, actin binding protein | -0.0274535 |
| RPL32 | ribosomal protein L32 | -0.0273393 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0272796 |
| ECT2 | epithelial cell transforming 2 | -0.0272236 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.0270661 |
| RPL23 | ribosomal protein L23 | -0.0265555 |
| RPLP1 | ribosomal protein, large, P1 | -0.0265497 |
| TRIM56 | tripartite motif containing 56 | -0.0265126 |
| PTGR1 | prostaglandin reductase 1 | -0.0264334 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.026364 |
