| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.209523 |
| MEST | mesoderm specific transcript | 0.205683 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0680975 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0677602 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0660049 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0574796 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0561864 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0560937 |
| RHOA | ras homolog family member A | 0.050839 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0476805 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0458289 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0450053 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0417796 |
| RPS18 | ribosomal protein S18 | 0.0405234 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0403187 |
| RNF145 | ring finger protein 145 | 0.0401316 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0400944 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0385963 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0385678 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0380457 |
| ITGAV | integrin, alpha V | 0.0365567 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0359026 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0335342 |
| UBTD2 | ubiquitin domain containing 2 | 0.0327056 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0323496 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.031418 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0310389 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0305965 |
| BBX | bobby sox homolog (Drosophila) | 0.0304245 |
| SMYD3 | SET and MYND domain containing 3 | 0.0302484 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0298626 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0292556 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0291485 |
| GSE1 | Gse1 coiled-coil protein | 0.0285947 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0283203 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0279726 |
| GPHN | gephyrin | 0.0278017 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0275716 |
| HOXC6 | homeobox C6 | 0.0274899 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0272869 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0266562 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0264681 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0257816 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0256862 |
| SUCO | SUN domain containing ossification factor | 0.0256512 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0255004 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0253856 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0253662 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0253543 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0248386 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.024776 |
| SKIL | SKI-like proto-oncogene | 0.0246269 |
| SETD5 | SET domain containing 5 | 0.0245146 |
| PDE10A | phosphodiesterase 10A | 0.0242107 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0236093 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0235615 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0235263 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0235098 |
| PCM1 | pericentriolar material 1 | 0.0233162 |
| MARCHF5 | membrane associated ring-CH-type finger 5 | 0.0231494 |
| SMAP1 | small ArfGAP 1 | 0.0230318 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0230022 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0227575 |
| RPL3 | ribosomal protein L3 | 0.0227496 |
| JUN | jun proto-oncogene | 0.0226975 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0225456 |
| CASC3 | cancer susceptibility candidate 3 | 0.0224399 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.0224238 |
| PRKD1 | protein kinase D1 | 0.0223848 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0223723 |
| MATR3 | matrin 3 | 0.0223385 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0223158 |
| ARF4 | ADP-ribosylation factor 4 | 0.0221909 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0219427 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.0217365 |
| REST | RE1-silencing transcription factor | 0.0216989 |
| ZNF91 | zinc finger protein 91 | 0.0216771 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0216564 |
| CCNL1 | cyclin L1 | 0.0215917 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0215617 |
| PHF21A | PHD finger protein 21A | 0.0214239 |
| VMP1 | vacuole membrane protein 1 | 0.0214216 |
| SLK | STE20-like kinase | 0.021417 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0213923 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0213376 |
| FOXP1 | forkhead box P1 | 0.0213302 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0212097 |
| TMSB4X | thymosin beta 4, X-linked | 0.021166 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0210875 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0208708 |
| SNX9 | sorting nexin 9 | 0.020725 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0206994 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0206949 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.0206796 |
| LYPLA1 | lysophospholipase I | 0.0205753 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 0.0205615 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0204936 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0203324 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0201529 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0200552 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PEG10 | paternally expressed 10 | -0.185075 |
| VIM | vimentin | -0.171936 |
| MGP | matrix Gla protein | -0.159088 |
| ACTG1 | actin gamma 1 | -0.099142 |
| CADM2 | cell adhesion molecule 2 | -0.094415 |
| HMGA2 | high mobility group AT-hook 2 | -0.089334 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0816292 |
| IER3 | immediate early response 3 | -0.0770317 |
| RPS8 | ribosomal protein S8 | -0.0742704 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0739851 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0738608 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.068275 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0640369 |
| RPS24 | ribosomal protein S24 | -0.058474 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0574921 |
| TMSB10 | thymosin beta 10 | -0.0560614 |
| RPLP1 | ribosomal protein, large, P1 | -0.0556676 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.054774 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0541127 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0538605 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.053306 |
| TBCA | tubulin folding cofactor A | -0.0520526 |
| RPL34 | ribosomal protein L34 | -0.0503272 |
| CENPF | centromere protein F, 350/400kDa | -0.0498809 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0492669 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0471802 |
| RPLP0 | ribosomal protein, large, P0 | -0.0465679 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0464317 |
| NFIB | nuclear factor I/B | -0.0450877 |
| RPL35A | ribosomal protein L35a | -0.0445263 |
| XPO1 | exportin 1 | -0.0424371 |
| RPL30 | ribosomal protein L30 | -0.0421976 |
| FNIP1 | folliculin interacting protein 1 | -0.0420218 |
| RLF | rearranged L-myc fusion | -0.0409357 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0393593 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0364983 |
| RPL37A | ribosomal protein L37a | -0.035756 |
| HDLBP | high density lipoprotein binding protein | -0.0353719 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0353548 |
| TET1 | tet methylcytosine dioxygenase 1 | -0.0346421 |
| KAZN | kazrin, periplakin interacting protein | -0.034591 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.034457 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0343994 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0343206 |
| NRF1 | nuclear respiratory factor 1 | -0.0339468 |
| RPS23 | ribosomal protein S23 | -0.0338814 |
| GNAS | GNAS complex locus | -0.0335204 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0332265 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.033184 |
| GOLGA4 | golgin A4 | -0.0328667 |
| RPL23 | ribosomal protein L23 | -0.0322068 |
| E2F3 | E2F transcription factor 3 | -0.0321307 |
| FOXC1 | forkhead box C1 | -0.0317594 |
| ZFHX3 | zinc finger homeobox 3 | -0.0314408 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0312947 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0312751 |
| CANX | calnexin | -0.0312219 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0305655 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0301887 |
| HMGB1 | high mobility group box 1 | -0.0301859 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0301496 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0299995 |
| RANBP17 | RAN binding protein 17 | -0.0297619 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0297014 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0296223 |
| RPL9 | ribosomal protein L9 | -0.0294046 |
| RPL19 | ribosomal protein L19 | -0.0291497 |
| RPS16 | ribosomal protein S16 | -0.0289464 |
| RSU1 | Ras suppressor protein 1 | -0.028725 |
| RPS11 | ribosomal protein S11 | -0.028614 |
| PTMA | prothymosin, alpha | -0.0284567 |
| RPS25 | ribosomal protein S25 | -0.0284321 |
| CTBP2 | C-terminal binding protein 2 | -0.0283911 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0282634 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0277866 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.0276667 |
| RPS12 | ribosomal protein S12 | -0.0275923 |
| HBP1 | HMG-box transcription factor 1 | -0.027399 |
| SBF2 | SET binding factor 2 | -0.0273482 |
| RPL38 | ribosomal protein L38 | -0.0270034 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0269032 |
| RPL13A | ribosomal protein L13a | -0.0269015 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0268962 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.026579 |
| RPL8 | ribosomal protein L8 | -0.0265667 |
| PARD3 | par-3 family cell polarity regulator | -0.0264377 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0262811 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0261 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0258076 |
| RPS10 | ribosomal protein S10 | -0.0256931 |
| LAMP1 | lysosomal-associated membrane protein 1 | -0.0255309 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.0251442 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0247497 |
| SHROOM3 | shroom family member 3 | -0.0247163 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0245681 |
| DENND5B | DENN/MADD domain containing 5B | -0.02451 |
| S100A9 | S100 calcium binding protein A9 | -0.0243092 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | -0.024295 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0242429 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0241571 |
