| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib (citrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.190763 |
| LMTK2 | lemur tyrosine kinase 2 | 0.061081 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0528307 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0451234 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0410449 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0353658 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0341071 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0327182 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.032477 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.028172 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0262574 |
| MSN | moesin | 0.025556 |
| BMP6 | bone morphogenetic protein 6 | 0.0252745 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0248696 |
| LAMB3 | laminin, beta 3 | 0.0231546 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.022963 |
| ANXA5 | annexin A5 | 0.0212375 |
| TPM3 | tropomyosin 3 | 0.0202494 |
| PMM2 | phosphomannomutase 2 | 0.019536 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0192191 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0186003 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0185875 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.018077 |
| CLMP | CXADR-like membrane protein | 0.0179986 |
| MATR3 | matrin 3 | 0.0176769 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0174941 |
| RASA3 | RAS p21 protein activator 3 | 0.0169966 |
| VEGFA | vascular endothelial growth factor A | 0.016498 |
| RPS2 | ribosomal protein S2 | 0.0164689 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0161346 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0159591 |
| ARF4 | ADP-ribosylation factor 4 | 0.0155279 |
| VMP1 | vacuole membrane protein 1 | 0.0153738 |
| RNF216 | ring finger protein 216 | 0.0153485 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0153005 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0152293 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0150755 |
| NUP58 | nucleoporin 58 | 0.0150385 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0149379 |
| MMP1 | matrix metallopeptidase 1 | 0.014789 |
| COG5 | component of oligomeric golgi complex 5 | 0.014315 |
| PROSER2 | proline and serine rich 2 | 0.0142768 |
| ATP13A3 | ATPase type 13A3 | 0.0139265 |
| SIK3 | SIK family kinase 3 | 0.0137934 |
| BCL2L1 | BCL2-like 1 | 0.0135758 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0134426 |
| MYO5B | myosin VB | 0.0133928 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0131518 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0126574 |
| RPS7 | ribosomal protein S7 | 0.0125519 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0125468 |
| FTL | ferritin, light polypeptide | 0.0123668 |
| SUCO | SUN domain containing ossification factor | 0.0123559 |
| FLNA | filamin A, alpha | 0.0123226 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | 0.012154 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0120185 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0120108 |
| YTHDC1 | YTH domain containing 1 | 0.0118548 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0118496 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0118255 |
| TMEM117 | transmembrane protein 117 | 0.0117984 |
| RPS18 | ribosomal protein S18 | 0.011698 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0116665 |
| FAM13A | family with sequence similarity 13, member A | 0.0115708 |
| CNST | consortin, connexin sorting protein | 0.0115595 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0115458 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0115041 |
| TMF1 | TATA element modulatory factor 1 | 0.0114369 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0114212 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0111442 |
| SBDS | Shwachman-Bodian-Diamond syndrome | 0.0111429 |
| SEPTIN9 | septin 9 | 0.0110442 |
| PTK2 | protein tyrosine kinase 2 | 0.0107803 |
| EVI5 | ecotropic viral integration site 5 | 0.0106039 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0105971 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.010364 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.0103014 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0102784 |
| RUNX1 | runt-related transcription factor 1 | 0.0102241 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0101956 |
| WDR43 | WD repeat domain 43 | 0.0101638 |
| PGM3 | phosphoglucomutase 3 | 0.010063 |
| SCFD2 | sec1 family domain containing 2 | 0.0100345 |
| MACROH2A1 | macroH2A.1 histone | 0.0099218 |
| MYO9B | myosin IXB | 0.00992111 |
| NUDCD3 | NudC domain containing 3 | 0.00987855 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | 0.0098417 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.00981928 |
| SGMS2 | sphingomyelin synthase 2 | 0.00970781 |
| FMNL2 | formin-like 2 | 0.00965968 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00959582 |
| PNN | pinin, desmosome associated protein | 0.00951169 |
| CASC3 | cancer susceptibility candidate 3 | 0.00939297 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.00932825 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.00931625 |
| CUL5 | cullin 5 | 0.00929913 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.00929536 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.00915443 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.0091096 |
| SEC24A | SEC24 family member A | 0.00907411 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.237348 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.157432 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.143127 |
| UBC | ubiquitin C | -0.135521 |
| LMO7 | LIM domain 7 | -0.133247 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.123511 |
| S100A10 | S100 calcium binding protein A10 | -0.101831 |
| AHNAK | AHNAK nucleoprotein | -0.101483 |
| VIM | vimentin | -0.0955139 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0885782 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0865217 |
| EGFR | epidermal growth factor receptor | -0.0839109 |
| MUC17 | mucin 17, cell surface associated | -0.0820999 |
| FLNB | filamin B, beta | -0.0768664 |
| POTEF | POTE ankyrin domain family, member F | -0.076092 |
| VCAN | versican | -0.0753276 |
| PTMA | prothymosin, alpha | -0.070966 |
| SDC4 | syndecan 4 | -0.0693464 |
| ASPH | aspartate beta-hydroxylase | -0.0692556 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0674294 |
| ITGA6 | integrin, alpha 6 | -0.0670492 |
| DSG2 | desmoglein 2 | -0.0653995 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0647033 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.064544 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0628478 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0622909 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0620857 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0612124 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.060991 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0588653 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.055955 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0548832 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0540582 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0536407 |
| LDHA | lactate dehydrogenase A | -0.0533469 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0527163 |
| NPSR1 | neuropeptide S receptor 1 | -0.0526831 |
| ACTG1 | actin gamma 1 | -0.0518355 |
| PERP | PERP, TP53 apoptosis effector | -0.0514935 |
| NDRG1 | N-myc downstream regulated 1 | -0.049734 |
| KLF6 | Kruppel-like factor 6 | -0.0494501 |
| HMGA1 | high mobility group AT-hook 1 | -0.0485243 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0472809 |
| EZR | ezrin | -0.0462696 |
| ANXA2 | annexin A2 | -0.0455488 |
| EMP1 | epithelial membrane protein 1 | -0.0450011 |
| S100A4 | S100 calcium binding protein A4 | -0.0423847 |
| CD2AP | CD2-associated protein | -0.0422041 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0418876 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0418446 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0413868 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.0408062 |
| GNAS | GNAS complex locus | -0.0393047 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0387579 |
| TSC22D2 | TSC22 domain family, member 2 | -0.038421 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0382073 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0379229 |
| SP100 | SP100 nuclear antigen | -0.0372522 |
| RPS27A | ribosomal protein S27a | -0.0370282 |
| PGK1 | phosphoglycerate kinase 1 | -0.0370069 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0367947 |
| KRT19 | keratin 19, type I | -0.0366337 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0361468 |
| S100A11 | S100 calcium binding protein A11 | -0.0359362 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.035711 |
| VCL | vinculin | -0.0356956 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0355511 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0355362 |
| SQSTM1 | sequestosome 1 | -0.0354254 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.035371 |
| B2M | beta-2-microglobulin | -0.0350049 |
| RPL12 | ribosomal protein L12 | -0.0347054 |
| MYOF | myoferlin | -0.0343461 |
| RPL23 | ribosomal protein L23 | -0.0342183 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0337537 |
| S100A6 | S100 calcium binding protein A6 | -0.0334499 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0328857 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0328664 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0328118 |
| RIGI | RNA sensor RIG-I | -0.0327772 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0322199 |
| RNF213 | ring finger protein 213 | -0.0319751 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0318872 |
| HMGA2 | high mobility group AT-hook 2 | -0.0317385 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0315842 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0313827 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0312885 |
| WASF2 | WAS protein family, member 2 | -0.0312642 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0307628 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0304201 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0303302 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0302979 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0302187 |
| PKM | pyruvate kinase, muscle | -0.0300738 |
| KRT8 | keratin 8, type II | -0.0298971 |
| RPL8 | ribosomal protein L8 | -0.0297109 |
| DIAPH2 | diaphanous-related formin 2 | -0.0296991 |
| LAMA4 | laminin, alpha 4 | -0.0295156 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0295105 |
| RPLP2 | ribosomal protein, large, P2 | -0.0290984 |
