| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib (citrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.163264 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.102937 |
| VMP1 | vacuole membrane protein 1 | 0.0778384 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0538363 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0529828 |
| SET | SET nuclear proto-oncogene | 0.0442615 |
| NTN4 | netrin 4 | 0.0437945 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0408942 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0363171 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0355675 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0343023 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0324084 |
| DUSP16 | dual specificity phosphatase 16 | 0.0322121 |
| MLPH | melanophilin | 0.0315931 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0309739 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0305223 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0299068 |
| TPM3 | tropomyosin 3 | 0.0293025 |
| PDLIM5 | PDZ and LIM domain 5 | 0.029023 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0289175 |
| MED13L | mediator complex subunit 13-like | 0.0274392 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0272294 |
| TMC5 | transmembrane channel-like 5 | 0.0268751 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0257031 |
| ENAH | enabled homolog (Drosophila) | 0.0256677 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0256042 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0248305 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0247974 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.024469 |
| EFNA1 | ephrin-A1 | 0.0244329 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.024307 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.024205 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0239899 |
| PTMA | prothymosin, alpha | 0.023833 |
| CCNL1 | cyclin L1 | 0.0237285 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0234906 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0227186 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0225586 |
| VEGFA | vascular endothelial growth factor A | 0.0222878 |
| KIF5B | kinesin family member 5B | 0.0216554 |
| INSR | insulin receptor | 0.021627 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0212461 |
| MATR3 | matrin 3 | 0.020882 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0206286 |
| FAT1 | FAT atypical cadherin 1 | 0.0206253 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0205052 |
| ABHD17C | abhydrolase domain containing 17C | 0.0205012 |
| SERINC3 | serine incorporator 3 | 0.0200346 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0196916 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0192839 |
| PGR | progesterone receptor | 0.0192553 |
| SGMS1 | sphingomyelin synthase 1 | 0.0190751 |
| AREG | amphiregulin | 0.0189226 |
| AHR | aryl hydrocarbon receptor | 0.0188658 |
| B2M | beta-2-microglobulin | 0.0188273 |
| ORMDL3 | ORMDL sphingolipid biosynthesis regulator 3 | 0.0187783 |
| AUTS2 | autism susceptibility candidate 2 | 0.0187638 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0187124 |
| NRCAM | neuronal cell adhesion molecule | 0.0185595 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0182792 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0181305 |
| NFIA | nuclear factor I/A | 0.0181103 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0180339 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0180094 |
| JUN | jun proto-oncogene | 0.0178832 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0178699 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.0172152 |
| PNN | pinin, desmosome associated protein | 0.017088 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0169526 |
| KLF6 | Kruppel-like factor 6 | 0.016896 |
| RPL26 | ribosomal protein L26 | 0.0167286 |
| NRP1 | neuropilin 1 | 0.0164431 |
| PLK2 | polo-like kinase 2 | 0.0163894 |
| VIM | vimentin | 0.0161883 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0160983 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0160365 |
| TC2N | tandem C2 domains, nuclear | 0.0158016 |
| SEPTIN9 | septin 9 | 0.0156271 |
| ANXA5 | annexin A5 | 0.0156 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0155735 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0155721 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0155676 |
| PLPP3 | phospholipid phosphatase 3 | 0.0154945 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0153771 |
| TES | testin LIM domain protein | 0.015377 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0153221 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0152194 |
| RAB30 | RAB30, member RAS oncogene family | 0.015113 |
| SMYD3 | SET and MYND domain containing 3 | 0.015071 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0150139 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0149846 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0149026 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.014829 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0145624 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.014534 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.014321 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0143041 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0142867 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0142122 |
| PRKD1 | protein kinase D1 | 0.0141416 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | -0.163481 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.140463 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0928742 |
| RPL19 | ribosomal protein L19 | -0.0911638 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0779544 |
| CLTC | clathrin, heavy chain (Hc) | -0.0749502 |
| NDRG1 | N-myc downstream regulated 1 | -0.0720621 |
| INTS6 | integrator complex subunit 6 | -0.0627204 |
| TMEM123 | transmembrane protein 123 | -0.0579448 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0562048 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0553559 |
| CDK12 | cyclin-dependent kinase 12 | -0.0552438 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0498024 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0492951 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0468134 |
| LASP1 | LIM and SH3 protein 1 | -0.0464786 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0462168 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0446882 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0441375 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.0412412 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0407155 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0403934 |
| DTNA | dystrobrevin, alpha | -0.0400288 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.039086 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0376999 |
| DENND1A | DENN/MADD domain containing 1A | -0.0376278 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0373414 |
| CEP250 | centrosomal protein 250kDa | -0.0369901 |
| SBF2 | SET binding factor 2 | -0.0364363 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0359155 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.035686 |
| ACTG1 | actin gamma 1 | -0.0351892 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0345924 |
| MCL1 | myeloid cell leukemia 1 | -0.0345364 |
| MMP24OS | MMP24 opposite strand | -0.0342014 |
| NABP1 | nucleic acid binding protein 1 | -0.0337842 |
| PLSCR2 | phospholipid scramblase 2 | -0.0336569 |
| ANKRD12 | ankyrin repeat domain 12 | -0.032581 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -0.0319542 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0315403 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0314596 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0307926 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0305866 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0301705 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0297025 |
| SP100 | SP100 nuclear antigen | -0.0294249 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0284085 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0282014 |
| RAB7A | RAB7A, member RAS oncogene family | -0.028094 |
| RCOR1 | REST corepressor 1 | -0.0279149 |
| PARD3 | par-3 family cell polarity regulator | -0.0277851 |
| HDLBP | high density lipoprotein binding protein | -0.0272842 |
| VCP | valosin containing protein | -0.0272115 |
| KIAA1217 | KIAA1217 | -0.0269051 |
| RTN3 | reticulon 3 | -0.0264924 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0263186 |
| KRT8 | keratin 8, type II | -0.0262776 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0262155 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0262044 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0260457 |
| FOXO3 | forkhead box O3 | -0.0251907 |
| SCFD1 | sec1 family domain containing 1 | -0.0250259 |
| ZNF292 | zinc finger protein 292 | -0.0250149 |
| ZNF207 | zinc finger protein 207 | -0.0249019 |
| SNX14 | sorting nexin 14 | -0.0247428 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.024632 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0246206 |
| RBM47 | RNA binding motif protein 47 | -0.0245168 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0244462 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.024069 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0239246 |
| ACSF2 | acyl-CoA synthetase family member 2 | -0.0236311 |
| UBAP2 | ubiquitin associated protein 2 | -0.0236122 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0235441 |
| TOB1 | transducer of ERBB2, 1 | -0.0234568 |
| FASN | fatty acid synthase | -0.0231063 |
| AFF1 | AF4/FMR2 family, member 1 | -0.02306 |
| USO1 | USO1 vesicle transport factor | -0.0222447 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0221142 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0219403 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0219087 |
| ADIPOR2 | adiponectin receptor 2 | -0.0218079 |
| MCU | mitochondrial calcium uniporter | -0.0215584 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0215001 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0213745 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0211599 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.021157 |
| UNC13B | unc-13 homolog B (C. elegans) | -0.0210457 |
| AEBP2 | AE binding protein 2 | -0.0206076 |
| STIP1 | stress-induced phosphoprotein 1 | -0.0205835 |
| EGR1 | early growth response 1 | -0.0205728 |
| ZNF217 | zinc finger protein 217 | -0.020539 |
| WASF2 | WAS protein family, member 2 | -0.0203115 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0203055 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.0201787 |
| PRELID2 | PRELI domain containing 2 | -0.0200343 |
| PLEKHG4B | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | -0.0199025 |
| ACTN4 | actinin, alpha 4 | -0.0198753 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0197491 |
| SHROOM3 | shroom family member 3 | -0.0196893 |
