| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.0860424 |
| NEBL | nebulette | 0.0801786 |
| RPL11 | ribosomal protein L11 | 0.0756551 |
| ATP11A | ATPase, class VI, type 11A | 0.0742884 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.074145 |
| MKI67 | marker of proliferation Ki-67 | 0.0668303 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0625137 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0587849 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0555405 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0511443 |
| RHOA | ras homolog family member A | 0.0507572 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0500353 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0492547 |
| CENPF | centromere protein F, 350/400kDa | 0.0460886 |
| RPL37 | ribosomal protein L37 | 0.0453509 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0448639 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.043902 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0418033 |
| DENND1A | DENN/MADD domain containing 1A | 0.0407531 |
| ATG10 | autophagy related 10 | 0.0401705 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0394571 |
| VEGFA | vascular endothelial growth factor A | 0.0391533 |
| WLS | wntless Wnt ligand secretion mediator | 0.0382724 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0372849 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0362993 |
| RPS2 | ribosomal protein S2 | 0.0358104 |
| ATF4 | activating transcription factor 4 | 0.0340711 |
| SET | SET nuclear proto-oncogene | 0.0339451 |
| CDH18 | cadherin 18, type 2 | 0.0333512 |
| CUX1 | cut-like homeobox 1 | 0.0331054 |
| PNN | pinin, desmosome associated protein | 0.0330453 |
| RPL26 | ribosomal protein L26 | 0.0322713 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | 0.0320155 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0319135 |
| RPS18 | ribosomal protein S18 | 0.0317819 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0316655 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0315171 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0315032 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0313623 |
| NGLY1 | N-glycanase 1 | 0.0312813 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0308908 |
| ENO1 | enolase 1, (alpha) | 0.0307978 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0305321 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.030221 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0301123 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0298728 |
| ZNF146 | zinc finger protein 146 | 0.029509 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0288813 |
| KIF5B | kinesin family member 5B | 0.0286577 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0280203 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0278057 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0275374 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0274733 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0274128 |
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 | 0.0273604 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0271877 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0271437 |
| RPAP2 | RNA polymerase II associated protein 2 | 0.0269301 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0266493 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0262371 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0261669 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0261486 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0260624 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0260488 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0260026 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0259109 |
| PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta | 0.025903 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0256506 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.025411 |
| CEP250 | centrosomal protein 250kDa | 0.0251666 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0250801 |
| TBC1D32 | TBC1 domain family, member 32 | 0.0250682 |
| HDAC8 | histone deacetylase 8 | 0.0250014 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0246623 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0245277 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0241685 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | 0.0240343 |
| GSE1 | Gse1 coiled-coil protein | 0.0237824 |
| BRCA1 | breast cancer 1, early onset | 0.0236574 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.0229347 |
| PRKCI | protein kinase C, iota | 0.0228298 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0228005 |
| PCM1 | pericentriolar material 1 | 0.0227498 |
| RACK1 | receptor for activated C kinase 1 | 0.0227054 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0226959 |
| VIM | vimentin | 0.0226541 |
| RPS7 | ribosomal protein S7 | 0.0224782 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.022306 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0223019 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0222344 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0221439 |
| RBM6 | RNA binding motif protein 6 | 0.0218056 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0217694 |
| RBBP4 | retinoblastoma binding protein 4 | 0.0217249 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0217095 |
| SMAD9 | SMAD family member 9 | 0.0214967 |
| SFSWAP | splicing factor, suppressor of white-apricot family | 0.0213769 |
| MATR3 | matrin 3 | 0.0213617 |
| SUGP2 | SURP and G patch domain containing 2 | 0.0213221 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0212012 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.157213 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.145822 |
| UBC | ubiquitin C | -0.136907 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.122617 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0972732 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0893845 |
| B2M | beta-2-microglobulin | -0.0861038 |
| RPL23 | ribosomal protein L23 | -0.0769426 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0767383 |
| RIGI | RNA sensor RIG-I | -0.0741461 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0720548 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0679532 |
| NPAS3 | neuronal PAS domain protein 3 | -0.067452 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0612563 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0576745 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0558156 |
| PTMA | prothymosin, alpha | -0.0555204 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0540279 |
| TMSB10 | thymosin beta 10 | -0.0512422 |
| ZNF608 | zinc finger protein 608 | -0.0498999 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0496839 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0490637 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0487257 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0480513 |
| CADM2 | cell adhesion molecule 2 | -0.0446546 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0444834 |
| VCL | vinculin | -0.0443895 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0438752 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0412273 |
| ATP9A | ATPase, class II, type 9A | -0.0404288 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0400692 |
| RPS27A | ribosomal protein S27a | -0.0391709 |
| EGR1 | early growth response 1 | -0.0388374 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0387916 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0380344 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0377633 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0377392 |
| TOP1 | topoisomerase (DNA) I | -0.0372102 |
| MCL1 | myeloid cell leukemia 1 | -0.0356031 |
| WDR45B | WD repeat domain 45B | -0.0344868 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0341695 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0341531 |
| VMP1 | vacuole membrane protein 1 | -0.034119 |
| TENM3 | teneurin transmembrane protein 3 | -0.0336219 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0328379 |
| RPL32 | ribosomal protein L32 | -0.0326119 |
| H1-0 | H1.0 linker histone | -0.0324727 |
| RBM33 | RNA binding motif protein 33 | -0.0322167 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0317279 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.030704 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0306897 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0303437 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0302373 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0300408 |
| RTN4 | reticulon 4 | -0.0299801 |
| SOX2 | SRY (sex determining region Y)-box 2 | -0.0299473 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0299184 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0296017 |
| HMGB1 | high mobility group box 1 | -0.0295718 |
| FNDC3B | fibronectin type III domain containing 3B | -0.029556 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0294924 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.0294901 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0293082 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0291954 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0291908 |
| FOXO3 | forkhead box O3 | -0.0291212 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0290583 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0290322 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.028917 |
| SEPTIN7 | septin 7 | -0.028814 |
| OGA | O-GlcNAcase | -0.0286999 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0284404 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0283344 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0282495 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0282095 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0280814 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0280375 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0280292 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0280159 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0278959 |
| TUBB | tubulin, beta class I | -0.0278552 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0278294 |
| EFNA5 | ephrin-A5 | -0.0276777 |
| NUP58 | nucleoporin 58 | -0.0275182 |
| ZNF217 | zinc finger protein 217 | -0.027497 |
| SYAP1 | synapse associated protein 1 | -0.0274788 |
| PCBP2 | poly(rC) binding protein 2 | -0.0274661 |
| SPAG9 | sperm associated antigen 9 | -0.0273444 |
| JMJD1C | jumonji domain containing 1C | -0.026851 |
| ANXA2 | annexin A2 | -0.0266689 |
| RAB7A | RAB7A, member RAS oncogene family | -0.026605 |
| RPS5 | ribosomal protein S5 | -0.0265774 |
| QKI | QKI, KH domain containing, RNA binding | -0.0262793 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0259628 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0258623 |
| TSC22D2 | TSC22 domain family, member 2 | -0.02579 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0257687 |
| EMP1 | epithelial membrane protein 1 | -0.0255974 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0254307 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0252573 |
